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Increased corticospinal excitability after 5 Hz rTMS over the human supplementary motor area.
J Physiol. 2005 Jan 01; 562(Pt 1):295-306.JP

Abstract

Transcranial magnetic stimulation (TMS) can produce effects not only at the site of stimulation but also at distant sites to which it projects. Here we examined the connection between supplementary motor area (SMA) and the hand area of the primary motor cortex (M1(Hand)) by testing whether prolonged repetitive TMS (rTMS) over the SMA can produce changes in excitability of the M1(Hand) after the end of the stimulus train. We evaluated motor-evoked potentials (MEPs) and the cortical silent period (CSP) evoked by a single-pulse TMS, short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) produced by a paired-pulse TMS, and forearm flexor H reflexes before and after 750 pulses of 5 Hz rTMS over SMA at an intensity of 110% active motor threshold (AMT) for the first dorsal interosseous (FDI) muscle. The amplitude of MEPs recorded from the right FDI muscle at rest as well as during voluntary contraction increased for at least 10 min after the end of rTMS, although the duration of the CSP, SICI and ICF did not change. There was no effect on H reflexes in the flexor carpi radialis muscle, even though the amplitude of the MEP obtained from the same muscle increased after rTMS. The effects on MEPs depended on the intensity of rTMS and were spatially specific to the SMA proper. We suggest that 5 Hz rTMS over SMA can induce a short-lasting facilitation in excitability of the M1(Hand) compatible with the anatomical connections between SMA and the M1(Hand).

Authors+Show Affiliations

Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 8-11 Queen Square, London WC1N 3BG, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15513947

Citation

Matsunaga, Kaoru, et al. "Increased Corticospinal Excitability After 5 Hz rTMS Over the Human Supplementary Motor Area." The Journal of Physiology, vol. 562, no. Pt 1, 2005, pp. 295-306.
Matsunaga K, Maruyama A, Fujiwara T, et al. Increased corticospinal excitability after 5 Hz rTMS over the human supplementary motor area. J Physiol. 2005;562(Pt 1):295-306.
Matsunaga, K., Maruyama, A., Fujiwara, T., Nakanishi, R., Tsuji, S., & Rothwell, J. C. (2005). Increased corticospinal excitability after 5 Hz rTMS over the human supplementary motor area. The Journal of Physiology, 562(Pt 1), 295-306.
Matsunaga K, et al. Increased Corticospinal Excitability After 5 Hz rTMS Over the Human Supplementary Motor Area. J Physiol. 2005 Jan 1;562(Pt 1):295-306. PubMed PMID: 15513947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased corticospinal excitability after 5 Hz rTMS over the human supplementary motor area. AU - Matsunaga,Kaoru, AU - Maruyama,Atsuo, AU - Fujiwara,Toshiyuki, AU - Nakanishi,Ryoji, AU - Tsuji,Sadatoshi, AU - Rothwell,John C, Y1 - 2004/10/28/ PY - 2004/10/30/pubmed PY - 2005/5/13/medline PY - 2004/10/30/entrez SP - 295 EP - 306 JF - The Journal of physiology JO - J Physiol VL - 562 IS - Pt 1 N2 - Transcranial magnetic stimulation (TMS) can produce effects not only at the site of stimulation but also at distant sites to which it projects. Here we examined the connection between supplementary motor area (SMA) and the hand area of the primary motor cortex (M1(Hand)) by testing whether prolonged repetitive TMS (rTMS) over the SMA can produce changes in excitability of the M1(Hand) after the end of the stimulus train. We evaluated motor-evoked potentials (MEPs) and the cortical silent period (CSP) evoked by a single-pulse TMS, short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) produced by a paired-pulse TMS, and forearm flexor H reflexes before and after 750 pulses of 5 Hz rTMS over SMA at an intensity of 110% active motor threshold (AMT) for the first dorsal interosseous (FDI) muscle. The amplitude of MEPs recorded from the right FDI muscle at rest as well as during voluntary contraction increased for at least 10 min after the end of rTMS, although the duration of the CSP, SICI and ICF did not change. There was no effect on H reflexes in the flexor carpi radialis muscle, even though the amplitude of the MEP obtained from the same muscle increased after rTMS. The effects on MEPs depended on the intensity of rTMS and were spatially specific to the SMA proper. We suggest that 5 Hz rTMS over SMA can induce a short-lasting facilitation in excitability of the M1(Hand) compatible with the anatomical connections between SMA and the M1(Hand). SN - 0022-3751 UR - https://www.unboundmedicine.com/medline/citation/15513947/Increased_corticospinal_excitability_after_5_Hz_rTMS_over_the_human_supplementary_motor_area_ L2 - https://doi.org/10.1113/jphysiol.2004.070755 DB - PRIME DP - Unbound Medicine ER -