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Serum and follicular resistin levels in women with polycystic ovarian syndrome during IVF-stimulated cycles.
Hum Reprod. 2005 Jan; 20(1):117-21.HR

Abstract

BACKGROUND

Resistin is a hormone linking obesity and insulin resistance. The aim of this study was to compare resistin levels in serum or follicular fluid from women with polycystic ovarian syndrome (PCOS) and controls, both of whom were undergoing IVF.

METHODS

We compared serum and follicular resistin levels in 21 PCOS women and in 18 healthy, normal ovulation, age- and body mass index (BMI)-matched non-PCOS women undergoing IVF. Correlations between serum or follicular fluid resistin levels and reproductive outcome were evaluated.

RESULTS

There was no significant difference in either serum or follicular resistin levels between the control group and the PCOS group as a whole or those with insulin resistance [homeostasis model assessment of insulin resistance index applied to oral glucose tolerance test (HOMA(OGTT)) <4.7]. However, resistin levels in follicular fluid were unexpectedly significantly lower than serum levels (P<0.0001) in both the PCOS and control groups. No significant correlation was found between resistin levels and BMI, estradiol, LH, or fasting or 2 h glucose or insulin levels or between follicular resistin levels and fertilization rate, implantation rate, clinical pregnancy rate, or early miscarriage rate in PCOS.

CONCLUSION

Resistin is unlikely to be a major determining factor in the growth and maturation of oocytes during IVF-stimulated cycles in PCOS.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, E-Da Hospital/I-Shou University, Kaohsiung County, Institute of Clinical Medicine and Institute of Physiology, National Yang-Ming University, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15513972

Citation

Seow, Kok-Min, et al. "Serum and Follicular Resistin Levels in Women With Polycystic Ovarian Syndrome During IVF-stimulated Cycles." Human Reproduction (Oxford, England), vol. 20, no. 1, 2005, pp. 117-21.
Seow KM, Juan CC, Hsu YP, et al. Serum and follicular resistin levels in women with polycystic ovarian syndrome during IVF-stimulated cycles. Hum Reprod. 2005;20(1):117-21.
Seow, K. M., Juan, C. C., Hsu, Y. P., Ho, L. T., Wang, Y. Y., & Hwang, J. L. (2005). Serum and follicular resistin levels in women with polycystic ovarian syndrome during IVF-stimulated cycles. Human Reproduction (Oxford, England), 20(1), 117-21.
Seow KM, et al. Serum and Follicular Resistin Levels in Women With Polycystic Ovarian Syndrome During IVF-stimulated Cycles. Hum Reprod. 2005;20(1):117-21. PubMed PMID: 15513972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum and follicular resistin levels in women with polycystic ovarian syndrome during IVF-stimulated cycles. AU - Seow,Kok-Min, AU - Juan,Chi-Chang, AU - Hsu,Yung-Pei, AU - Ho,Low-Tone, AU - Wang,Yuan-Yung, AU - Hwang,Jiann-Loung, Y1 - 2004/10/28/ PY - 2004/10/30/pubmed PY - 2005/6/14/medline PY - 2004/10/30/entrez SP - 117 EP - 21 JF - Human reproduction (Oxford, England) JO - Hum Reprod VL - 20 IS - 1 N2 - BACKGROUND: Resistin is a hormone linking obesity and insulin resistance. The aim of this study was to compare resistin levels in serum or follicular fluid from women with polycystic ovarian syndrome (PCOS) and controls, both of whom were undergoing IVF. METHODS: We compared serum and follicular resistin levels in 21 PCOS women and in 18 healthy, normal ovulation, age- and body mass index (BMI)-matched non-PCOS women undergoing IVF. Correlations between serum or follicular fluid resistin levels and reproductive outcome were evaluated. RESULTS: There was no significant difference in either serum or follicular resistin levels between the control group and the PCOS group as a whole or those with insulin resistance [homeostasis model assessment of insulin resistance index applied to oral glucose tolerance test (HOMA(OGTT)) <4.7]. However, resistin levels in follicular fluid were unexpectedly significantly lower than serum levels (P<0.0001) in both the PCOS and control groups. No significant correlation was found between resistin levels and BMI, estradiol, LH, or fasting or 2 h glucose or insulin levels or between follicular resistin levels and fertilization rate, implantation rate, clinical pregnancy rate, or early miscarriage rate in PCOS. CONCLUSION: Resistin is unlikely to be a major determining factor in the growth and maturation of oocytes during IVF-stimulated cycles in PCOS. SN - 0268-1161 UR - https://www.unboundmedicine.com/medline/citation/15513972/Serum_and_follicular_resistin_levels_in_women_with_polycystic_ovarian_syndrome_during_IVF_stimulated_cycles_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/deh589 DB - PRIME DP - Unbound Medicine ER -