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Chemokines in the pathogenesis of vascular disease.
Circ Res. 2004 Oct 29; 95(9):858-66.CircR

Abstract

Our increasing appreciation of the importance of inflammation in vascular disease has focused attention on the molecules that direct the migration of leukocytes from the blood stream to the vessel wall. In this review, we summarize roles of the chemokines, a family of small secreted proteins that selectively recruit monocytes, neutrophils, and lymphocytes to sites of vascular injury, inflammation, and developing atherosclerosis. Chemokines induce chemotaxis through the activation of G-protein-coupled receptors, and the receptors that a given leukocyte expresses determines the chemokines to which it will respond. Monocyte chemoattractant protein 1 (MCP-1), acting through its receptor CCR2, appears to play an early and important role in the recruitment of monocytes to atherosclerotic lesions and in the formation of intimal hyperplasia after arterial injury. Acute thrombosis is an often fatal complication of atherosclerotic plaque rupture, and recent evidence suggests that MCP-1 contributes to thrombin generation and thrombus formation by generating tissue factor. Because of their critical roles in monocyte recruitment in vascular and nonvascular diseases, MCP-1 and CCR2 have become important therapeutic targets, and efforts are underway to develop potent and specific antagonists of these and related chemokines.

Authors+Show Affiliations

Gladstone Institute of Cardiovascular Disease, PO Box 419100, San Francisco, CA 94141-9100, USA. icharo@gladstone.ucsf.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15514167

Citation

Charo, Israel F., and Mark B. Taubman. "Chemokines in the Pathogenesis of Vascular Disease." Circulation Research, vol. 95, no. 9, 2004, pp. 858-66.
Charo IF, Taubman MB. Chemokines in the pathogenesis of vascular disease. Circ Res. 2004;95(9):858-66.
Charo, I. F., & Taubman, M. B. (2004). Chemokines in the pathogenesis of vascular disease. Circulation Research, 95(9), 858-66.
Charo IF, Taubman MB. Chemokines in the Pathogenesis of Vascular Disease. Circ Res. 2004 Oct 29;95(9):858-66. PubMed PMID: 15514167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemokines in the pathogenesis of vascular disease. AU - Charo,Israel F, AU - Taubman,Mark B, PY - 2004/10/30/pubmed PY - 2005/5/13/medline PY - 2004/10/30/entrez SP - 858 EP - 66 JF - Circulation research JO - Circ Res VL - 95 IS - 9 N2 - Our increasing appreciation of the importance of inflammation in vascular disease has focused attention on the molecules that direct the migration of leukocytes from the blood stream to the vessel wall. In this review, we summarize roles of the chemokines, a family of small secreted proteins that selectively recruit monocytes, neutrophils, and lymphocytes to sites of vascular injury, inflammation, and developing atherosclerosis. Chemokines induce chemotaxis through the activation of G-protein-coupled receptors, and the receptors that a given leukocyte expresses determines the chemokines to which it will respond. Monocyte chemoattractant protein 1 (MCP-1), acting through its receptor CCR2, appears to play an early and important role in the recruitment of monocytes to atherosclerotic lesions and in the formation of intimal hyperplasia after arterial injury. Acute thrombosis is an often fatal complication of atherosclerotic plaque rupture, and recent evidence suggests that MCP-1 contributes to thrombin generation and thrombus formation by generating tissue factor. Because of their critical roles in monocyte recruitment in vascular and nonvascular diseases, MCP-1 and CCR2 have become important therapeutic targets, and efforts are underway to develop potent and specific antagonists of these and related chemokines. SN - 1524-4571 UR - https://www.unboundmedicine.com/medline/citation/15514167/Chemokines_in_the_pathogenesis_of_vascular_disease_ L2 - https://www.ahajournals.org/doi/10.1161/01.RES.0000146672.10582.17?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -