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Association between prenatal exposure to analgesics and risk of schizophrenia.

Abstract

BACKGROUND

Disturbances in the central nervous system originating during foetal life may increase the risk of schizophrenia.

AIMS

To illuminate the hypothesis that prenatal exposure to analgesics may affect foetal neurodevelopment, leading to increased risk of schizophrenia in adulthood.

METHOD

Using data from the Copenhagen Perinatal Cohort and from the Danish Psychiatric Central Register, we studied the relationship between prenatal exposure to analgesics and the risk of schizophrenia. The effect of prenatal exposure was adjusted for parental history of schizophrenia, second-trimester viral infections, concomitant drug treatment during pregnancy, an index of pregnancy complications, parental social status and parental age.

RESULTS

In a risk set of 7999 individuals, 116 cases of schizophrenia were found (1.5%). Prenatal exposure to analgesics in the second trimester was associated with an elevated risk (adjusted odds ratio 4.75, 95% CI1.9-12.0). Independent of the covariates, the effect remained statistically significant.

CONCLUSIONS

Independent of a wide range of possible confounders, a significant association between second-trimester exposure to analgesics and increased risk of schizophrenia was observed.

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  • Authors+Show Affiliations

    ,

    Department of Health Psychology, Copenhagen University, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark.

    , ,

    Source

    MeSH

    Adult
    Analgesics
    Cohort Studies
    Female
    Humans
    Male
    Odds Ratio
    Pregnancy
    Pregnancy Trimester, Second
    Pregnancy Trimester, Third
    Prenatal Exposure Delayed Effects
    Risk Factors
    Schizophrenia

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15516543

    Citation

    Sørensen, Holger J., et al. "Association Between Prenatal Exposure to Analgesics and Risk of Schizophrenia." The British Journal of Psychiatry : the Journal of Mental Science, vol. 185, 2004, pp. 366-71.
    Sørensen HJ, Mortensen EL, Reinisch JM, et al. Association between prenatal exposure to analgesics and risk of schizophrenia. Br J Psychiatry. 2004;185:366-71.
    Sørensen, H. J., Mortensen, E. L., Reinisch, J. M., & Mednick, S. A. (2004). Association between prenatal exposure to analgesics and risk of schizophrenia. The British Journal of Psychiatry : the Journal of Mental Science, 185, pp. 366-71.
    Sørensen HJ, et al. Association Between Prenatal Exposure to Analgesics and Risk of Schizophrenia. Br J Psychiatry. 2004;185:366-71. PubMed PMID: 15516543.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between prenatal exposure to analgesics and risk of schizophrenia. AU - Sørensen,Holger J, AU - Mortensen,Erik L, AU - Reinisch,June M, AU - Mednick,Sarnoff A, PY - 2004/11/2/pubmed PY - 2005/4/9/medline PY - 2004/11/2/entrez SP - 366 EP - 71 JF - The British journal of psychiatry : the journal of mental science JO - Br J Psychiatry VL - 185 N2 - BACKGROUND: Disturbances in the central nervous system originating during foetal life may increase the risk of schizophrenia. AIMS: To illuminate the hypothesis that prenatal exposure to analgesics may affect foetal neurodevelopment, leading to increased risk of schizophrenia in adulthood. METHOD: Using data from the Copenhagen Perinatal Cohort and from the Danish Psychiatric Central Register, we studied the relationship between prenatal exposure to analgesics and the risk of schizophrenia. The effect of prenatal exposure was adjusted for parental history of schizophrenia, second-trimester viral infections, concomitant drug treatment during pregnancy, an index of pregnancy complications, parental social status and parental age. RESULTS: In a risk set of 7999 individuals, 116 cases of schizophrenia were found (1.5%). Prenatal exposure to analgesics in the second trimester was associated with an elevated risk (adjusted odds ratio 4.75, 95% CI1.9-12.0). Independent of the covariates, the effect remained statistically significant. CONCLUSIONS: Independent of a wide range of possible confounders, a significant association between second-trimester exposure to analgesics and increased risk of schizophrenia was observed. SN - 0007-1250 UR - https://www.unboundmedicine.com/medline/citation/15516543/full_citation L2 - https://www.cambridge.org/core/product/identifier/S0007125000229668/type/journal_article DB - PRIME DP - Unbound Medicine ER -