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Association between prenatal exposure to analgesics and risk of schizophrenia.
Br J Psychiatry 2004; 185:366-71BJ

Abstract

BACKGROUND

Disturbances in the central nervous system originating during foetal life may increase the risk of schizophrenia.

AIMS

To illuminate the hypothesis that prenatal exposure to analgesics may affect foetal neurodevelopment, leading to increased risk of schizophrenia in adulthood.

METHOD

Using data from the Copenhagen Perinatal Cohort and from the Danish Psychiatric Central Register, we studied the relationship between prenatal exposure to analgesics and the risk of schizophrenia. The effect of prenatal exposure was adjusted for parental history of schizophrenia, second-trimester viral infections, concomitant drug treatment during pregnancy, an index of pregnancy complications, parental social status and parental age.

RESULTS

In a risk set of 7999 individuals, 116 cases of schizophrenia were found (1.5%). Prenatal exposure to analgesics in the second trimester was associated with an elevated risk (adjusted odds ratio 4.75, 95% CI1.9-12.0). Independent of the covariates, the effect remained statistically significant.

CONCLUSIONS

Independent of a wide range of possible confounders, a significant association between second-trimester exposure to analgesics and increased risk of schizophrenia was observed.

Authors+Show Affiliations

Department of Health Psychology, Copenhagen University, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15516543

Citation

Sørensen, Holger J., et al. "Association Between Prenatal Exposure to Analgesics and Risk of Schizophrenia." The British Journal of Psychiatry : the Journal of Mental Science, vol. 185, 2004, pp. 366-71.
Sørensen HJ, Mortensen EL, Reinisch JM, et al. Association between prenatal exposure to analgesics and risk of schizophrenia. Br J Psychiatry. 2004;185:366-71.
Sørensen, H. J., Mortensen, E. L., Reinisch, J. M., & Mednick, S. A. (2004). Association between prenatal exposure to analgesics and risk of schizophrenia. The British Journal of Psychiatry : the Journal of Mental Science, 185, pp. 366-71.
Sørensen HJ, et al. Association Between Prenatal Exposure to Analgesics and Risk of Schizophrenia. Br J Psychiatry. 2004;185:366-71. PubMed PMID: 15516543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between prenatal exposure to analgesics and risk of schizophrenia. AU - Sørensen,Holger J, AU - Mortensen,Erik L, AU - Reinisch,June M, AU - Mednick,Sarnoff A, PY - 2004/11/2/pubmed PY - 2005/4/9/medline PY - 2004/11/2/entrez SP - 366 EP - 71 JF - The British journal of psychiatry : the journal of mental science JO - Br J Psychiatry VL - 185 N2 - BACKGROUND: Disturbances in the central nervous system originating during foetal life may increase the risk of schizophrenia. AIMS: To illuminate the hypothesis that prenatal exposure to analgesics may affect foetal neurodevelopment, leading to increased risk of schizophrenia in adulthood. METHOD: Using data from the Copenhagen Perinatal Cohort and from the Danish Psychiatric Central Register, we studied the relationship between prenatal exposure to analgesics and the risk of schizophrenia. The effect of prenatal exposure was adjusted for parental history of schizophrenia, second-trimester viral infections, concomitant drug treatment during pregnancy, an index of pregnancy complications, parental social status and parental age. RESULTS: In a risk set of 7999 individuals, 116 cases of schizophrenia were found (1.5%). Prenatal exposure to analgesics in the second trimester was associated with an elevated risk (adjusted odds ratio 4.75, 95% CI1.9-12.0). Independent of the covariates, the effect remained statistically significant. CONCLUSIONS: Independent of a wide range of possible confounders, a significant association between second-trimester exposure to analgesics and increased risk of schizophrenia was observed. SN - 0007-1250 UR - http://www.unboundmedicine.com/medline/citation/15516543/full_citation L2 - https://www.cambridge.org/core/product/identifier/S0007125000229668/type/journal_article DB - PRIME DP - Unbound Medicine ER -