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Does tibolone affect serum leptin levels and body weight in postmenopausal women?
Arch Gynecol Obstet. 2005 Jul; 272(2):127-30.AG

Abstract

OBJECTIVES

Leptin has a significant role in body weight regulation and energy balance. We examined the effect of tibolone on the body weight and serum leptin levels in postmenopausal women.

STUDY DESIGN

Twenty women (aged 43-60 years) participated in this prospective study. All women in this study protocol received 2.5 mg/day of tibolone. Absolute and body mass index (BMI)-corrected serum leptin concentrations and BMI values were measured at baseline, after 3 months, and after 6 months of the tibolone therapy.

RESULTS

Tibolone did not affect absolute and BMI-corrected serum leptin levels, and BMI values during the treatment. A significant linear correlation between BMI values and serum leptin levels was observed (p<0.05, r=0.67).

CONCLUSIONS

Tibolone seems not to affect serum leptin levels, body weight and BMI values of postmenopausal women. There is a significant correlation between serum leptin levels and BMI values.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Faculty of Medicine, Dokuz Eylul University, Bornova, Izmir, Turkey. mert.gol@deu.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

15517326

Citation

Gol, Mert, et al. "Does Tibolone Affect Serum Leptin Levels and Body Weight in Postmenopausal Women?" Archives of Gynecology and Obstetrics, vol. 272, no. 2, 2005, pp. 127-30.
Gol M, Ozsener S, Sendag F, et al. Does tibolone affect serum leptin levels and body weight in postmenopausal women? Arch Gynecol Obstet. 2005;272(2):127-30.
Gol, M., Ozsener, S., Sendag, F., Uretmen, S., Oztekin, K., Tanyalcin, T., & Bilgin, O. (2005). Does tibolone affect serum leptin levels and body weight in postmenopausal women? Archives of Gynecology and Obstetrics, 272(2), 127-30.
Gol M, et al. Does Tibolone Affect Serum Leptin Levels and Body Weight in Postmenopausal Women. Arch Gynecol Obstet. 2005;272(2):127-30. PubMed PMID: 15517326.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does tibolone affect serum leptin levels and body weight in postmenopausal women? AU - Gol,Mert, AU - Ozsener,Serdar, AU - Sendag,Fatih, AU - Uretmen,Sevinç, AU - Oztekin,Kemal, AU - Tanyalcin,Tijen, AU - Bilgin,Onur, Y1 - 2004/10/29/ PY - 2004/06/30/received PY - 2004/08/27/accepted PY - 2004/11/2/pubmed PY - 2005/12/13/medline PY - 2004/11/2/entrez SP - 127 EP - 30 JF - Archives of gynecology and obstetrics JO - Arch Gynecol Obstet VL - 272 IS - 2 N2 - OBJECTIVES: Leptin has a significant role in body weight regulation and energy balance. We examined the effect of tibolone on the body weight and serum leptin levels in postmenopausal women. STUDY DESIGN: Twenty women (aged 43-60 years) participated in this prospective study. All women in this study protocol received 2.5 mg/day of tibolone. Absolute and body mass index (BMI)-corrected serum leptin concentrations and BMI values were measured at baseline, after 3 months, and after 6 months of the tibolone therapy. RESULTS: Tibolone did not affect absolute and BMI-corrected serum leptin levels, and BMI values during the treatment. A significant linear correlation between BMI values and serum leptin levels was observed (p<0.05, r=0.67). CONCLUSIONS: Tibolone seems not to affect serum leptin levels, body weight and BMI values of postmenopausal women. There is a significant correlation between serum leptin levels and BMI values. SN - 0932-0067 UR - https://www.unboundmedicine.com/medline/citation/15517326/Does_tibolone_affect_serum_leptin_levels_and_body_weight_in_postmenopausal_women L2 - https://dx.doi.org/10.1007/s00404-004-0686-y DB - PRIME DP - Unbound Medicine ER -