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Serum adiponectin levels in adult growth hormone deficiency and acromegaly.
Growth Horm IGF Res. 2004 Dec; 14(6):449-54.GH

Abstract

Atherosclerosis and insulin resistance are common complications of adult growth hormone deficiency (GHD) and acromegaly. Circulating adiponectin, an adipocyte-derived protein, has both anti-atherogenic and insulin-sensitising effects. In this study, we measured serum adiponectin levels in patients with either adult GHD or acromegaly to clarify the impact of GH secretory states on the regulation of serum adiponectin levels. Serum adiponectin level was measured by radioimmunoassay in 32 patients with adult GHD, 49 patients with acromegaly and 25 normal subjects. The relationships between adiponectin and insulin sensitivity index assessed as quantitative insulin sensitivity check index (QUICKI), BMI, and serum GH and IGF-I levels were then investigated. The values of QUICKI were significantly lower in patients with acromegaly or adult GHD compared to normal subjects (0.33 +/- 0.03, P < 0.01, 0.35 +/- 0.04, P < 0.05 and 0.36 +/- 0.01, respectively). While patients with adult GHD had significantly lower serum adiponectin levels than patients with acromegaly (6.5 +/- 3.9, 9.2 +/- 5.0, P < 0.01) these levels were not significantly different from those found in normal subjects (7.8 +/- 4.3 mug/ml). There was an inverse correlation between serum adiponectin levels and BMI in both patient groups (GHD r = -0.39, P < 0.05; Acromegaly r = -0.35, P < 0.05). However, serum adiponectin levels correlated positively with QUICKI (R(s) = 0.37, P < 0.05) only in patients with adult GHD. In patients with acromegaly, the levels of circulating adiponectin showed an inverse correlation with serum IGF-I levels (R(s) = -0.34, P < 0.05), but not with basal GH levels. These results demonstrate that adiponectin levels are significantly lower in patients with adult GHD than in patients with acromegaly. Adiponectin levels are similar in patients with GHD and healthy controls, whereas in patients with acromegaly, insulin resistance appears to be not closely related to adiponectin levels compared with BMI. The different relationship between adiponectin and QUICKI observed in the adult GHD and acromegaly groups presumably reflects differences in the mechanisms of insulin resistance under states of GH deficiency or excess.

Authors+Show Affiliations

Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. izumif@endm.twmu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15519253

Citation

Fukuda, Izumi, et al. "Serum Adiponectin Levels in Adult Growth Hormone Deficiency and Acromegaly." Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society, vol. 14, no. 6, 2004, pp. 449-54.
Fukuda I, Hizuka N, Ishikawa Y, et al. Serum adiponectin levels in adult growth hormone deficiency and acromegaly. Growth Horm IGF Res. 2004;14(6):449-54.
Fukuda, I., Hizuka, N., Ishikawa, Y., Itoh, E., Yasumoto, K., Murakami, Y., Sata, A., Tsukada, J., Kurimoto, M., Okubo, Y., & Takano, K. (2004). Serum adiponectin levels in adult growth hormone deficiency and acromegaly. Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society, 14(6), 449-54.
Fukuda I, et al. Serum Adiponectin Levels in Adult Growth Hormone Deficiency and Acromegaly. Growth Horm IGF Res. 2004;14(6):449-54. PubMed PMID: 15519253.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum adiponectin levels in adult growth hormone deficiency and acromegaly. AU - Fukuda,Izumi, AU - Hizuka,Naomi, AU - Ishikawa,Yukiko, AU - Itoh,Emina, AU - Yasumoto,Kumiko, AU - Murakami,Yuko, AU - Sata,Akira, AU - Tsukada,Junko, AU - Kurimoto,Makiko, AU - Okubo,Yumiko, AU - Takano,Kazue, PY - 2003/12/29/received PY - 2004/06/28/revised PY - 2004/06/28/accepted PY - 2004/11/3/pubmed PY - 2005/3/30/medline PY - 2004/11/3/entrez SP - 449 EP - 54 JF - Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society JO - Growth Horm. IGF Res. VL - 14 IS - 6 N2 - Atherosclerosis and insulin resistance are common complications of adult growth hormone deficiency (GHD) and acromegaly. Circulating adiponectin, an adipocyte-derived protein, has both anti-atherogenic and insulin-sensitising effects. In this study, we measured serum adiponectin levels in patients with either adult GHD or acromegaly to clarify the impact of GH secretory states on the regulation of serum adiponectin levels. Serum adiponectin level was measured by radioimmunoassay in 32 patients with adult GHD, 49 patients with acromegaly and 25 normal subjects. The relationships between adiponectin and insulin sensitivity index assessed as quantitative insulin sensitivity check index (QUICKI), BMI, and serum GH and IGF-I levels were then investigated. The values of QUICKI were significantly lower in patients with acromegaly or adult GHD compared to normal subjects (0.33 +/- 0.03, P < 0.01, 0.35 +/- 0.04, P < 0.05 and 0.36 +/- 0.01, respectively). While patients with adult GHD had significantly lower serum adiponectin levels than patients with acromegaly (6.5 +/- 3.9, 9.2 +/- 5.0, P < 0.01) these levels were not significantly different from those found in normal subjects (7.8 +/- 4.3 mug/ml). There was an inverse correlation between serum adiponectin levels and BMI in both patient groups (GHD r = -0.39, P < 0.05; Acromegaly r = -0.35, P < 0.05). However, serum adiponectin levels correlated positively with QUICKI (R(s) = 0.37, P < 0.05) only in patients with adult GHD. In patients with acromegaly, the levels of circulating adiponectin showed an inverse correlation with serum IGF-I levels (R(s) = -0.34, P < 0.05), but not with basal GH levels. These results demonstrate that adiponectin levels are significantly lower in patients with adult GHD than in patients with acromegaly. Adiponectin levels are similar in patients with GHD and healthy controls, whereas in patients with acromegaly, insulin resistance appears to be not closely related to adiponectin levels compared with BMI. The different relationship between adiponectin and QUICKI observed in the adult GHD and acromegaly groups presumably reflects differences in the mechanisms of insulin resistance under states of GH deficiency or excess. SN - 1096-6374 UR - https://www.unboundmedicine.com/medline/citation/15519253/Serum_adiponectin_levels_in_adult_growth_hormone_deficiency_and_acromegaly_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1096-6374(04)00130-3 DB - PRIME DP - Unbound Medicine ER -