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Comparison of two combined vaccines against typhoid fever and hepatitis A in healthy adults.
Vaccine. 2004 Nov 15; 23(1):29-35.V

Abstract

A prospective, randomised, observer-blind, comparative study was performed in healthy adults with a new hepatitis A/typhoid combined vaccine, Viatim, and the marketed Hepatyrix vaccine. Both vaccines induced high levels of protective antibodies, but typhoid responses were higher and hepatitis A responses more rapid with Viatim compared with Hepatyrix. Both vaccines were well tolerated, no serious adverse events (SAEs) occurred, but more Viatim vaccinees had more mild or moderate local reactions (82.7%) than Hepatyrix (53.1%, p < 0.001). In this direct comparison Viatim induced more local reactions, but elicited a more rapid and higher immune response to both antigens than Hepatyrix.

Authors+Show Affiliations

Clinical Research Group, Liverpool School of Tropical Medicine, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15519704

Citation

Beeching, Nicholas J., et al. "Comparison of Two Combined Vaccines Against Typhoid Fever and Hepatitis a in Healthy Adults." Vaccine, vol. 23, no. 1, 2004, pp. 29-35.
Beeching NJ, Clarke PD, Kitchin NR, et al. Comparison of two combined vaccines against typhoid fever and hepatitis A in healthy adults. Vaccine. 2004;23(1):29-35.
Beeching, N. J., Clarke, P. D., Kitchin, N. R., Pirmohamed, J., Veitch, K., & Weber, F. (2004). Comparison of two combined vaccines against typhoid fever and hepatitis A in healthy adults. Vaccine, 23(1), 29-35.
Beeching NJ, et al. Comparison of Two Combined Vaccines Against Typhoid Fever and Hepatitis a in Healthy Adults. Vaccine. 2004 Nov 15;23(1):29-35. PubMed PMID: 15519704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of two combined vaccines against typhoid fever and hepatitis A in healthy adults. AU - Beeching,Nicholas J, AU - Clarke,Paul D, AU - Kitchin,Nicholas R E, AU - Pirmohamed,Jackie, AU - Veitch,Keith, AU - Weber,Françoise, PY - 2004/03/16/received PY - 2004/05/31/accepted PY - 2004/11/3/pubmed PY - 2005/2/5/medline PY - 2004/11/3/entrez SP - 29 EP - 35 JF - Vaccine JO - Vaccine VL - 23 IS - 1 N2 - A prospective, randomised, observer-blind, comparative study was performed in healthy adults with a new hepatitis A/typhoid combined vaccine, Viatim, and the marketed Hepatyrix vaccine. Both vaccines induced high levels of protective antibodies, but typhoid responses were higher and hepatitis A responses more rapid with Viatim compared with Hepatyrix. Both vaccines were well tolerated, no serious adverse events (SAEs) occurred, but more Viatim vaccinees had more mild or moderate local reactions (82.7%) than Hepatyrix (53.1%, p < 0.001). In this direct comparison Viatim induced more local reactions, but elicited a more rapid and higher immune response to both antigens than Hepatyrix. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/15519704/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(04)00645-0 DB - PRIME DP - Unbound Medicine ER -