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Cerebral venous sinus thrombosis and thrombophilia presenting as pseudo-tumour syndrome following mild head injury.
J Clin Neurosci. 2004 Nov; 11(8):924-7.JC

Abstract

Cerebral venous sinus thrombosis (CVT) after mild head injury is infrequent. A 38-year-old patient presented with a Glasgow Coma score (GCS) of 15 after a road traffic accident. CT scan revealed a temporal contusion. He was treated with measures to prevent cerebral oedema and anticonvulsants. Three weeks later he presented with features of pseudo-tumour syndrome. Investigations revealed the presence of cerebral venous sinus thrombosis, protein C deficiency and elevated titres of antiphospholipid antibodies. He was treated with anticoagulants and showed improvement. This case report highlights that multiple "hits" may lead to CVT and hence laboratory screening of patients with CVT is necessary even if the clinical situation seemingly provides sufficient explanation for a thrombotic event. The presence of acquired and inherited causes of thrombophilia need not always lead to symptomatic thrombosis. As illustrated by this case, a second hit, such as trauma, may be the precipitating factor that unmasks the prothrombotic state.

Authors+Show Affiliations

JJ Hospitals, Madurai, India. prasan86@eth.net

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15519881

Citation

Muthukumar, N. "Cerebral Venous Sinus Thrombosis and Thrombophilia Presenting as Pseudo-tumour Syndrome Following Mild Head Injury." Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, vol. 11, no. 8, 2004, pp. 924-7.
Muthukumar N. Cerebral venous sinus thrombosis and thrombophilia presenting as pseudo-tumour syndrome following mild head injury. J Clin Neurosci. 2004;11(8):924-7.
Muthukumar, N. (2004). Cerebral venous sinus thrombosis and thrombophilia presenting as pseudo-tumour syndrome following mild head injury. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 11(8), 924-7.
Muthukumar N. Cerebral Venous Sinus Thrombosis and Thrombophilia Presenting as Pseudo-tumour Syndrome Following Mild Head Injury. J Clin Neurosci. 2004;11(8):924-7. PubMed PMID: 15519881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebral venous sinus thrombosis and thrombophilia presenting as pseudo-tumour syndrome following mild head injury. A1 - Muthukumar,N, PY - 2003/05/22/received PY - 2003/10/03/accepted PY - 2004/11/3/pubmed PY - 2008/1/18/medline PY - 2004/11/3/entrez SP - 924 EP - 7 JF - Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia JO - J Clin Neurosci VL - 11 IS - 8 N2 - Cerebral venous sinus thrombosis (CVT) after mild head injury is infrequent. A 38-year-old patient presented with a Glasgow Coma score (GCS) of 15 after a road traffic accident. CT scan revealed a temporal contusion. He was treated with measures to prevent cerebral oedema and anticonvulsants. Three weeks later he presented with features of pseudo-tumour syndrome. Investigations revealed the presence of cerebral venous sinus thrombosis, protein C deficiency and elevated titres of antiphospholipid antibodies. He was treated with anticoagulants and showed improvement. This case report highlights that multiple "hits" may lead to CVT and hence laboratory screening of patients with CVT is necessary even if the clinical situation seemingly provides sufficient explanation for a thrombotic event. The presence of acquired and inherited causes of thrombophilia need not always lead to symptomatic thrombosis. As illustrated by this case, a second hit, such as trauma, may be the precipitating factor that unmasks the prothrombotic state. SN - 0967-5868 UR - https://www.unboundmedicine.com/medline/citation/15519881/Cerebral_venous_sinus_thrombosis_and_thrombophilia_presenting_as_pseudo_tumour_syndrome_following_mild_head_injury_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0967-5868(04)00221-8 DB - PRIME DP - Unbound Medicine ER -