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Inhibin B and anti-Mullerian hormone: markers of ovarian response in IVF/ICSI patients?
BJOG. 2004 Nov; 111(11):1248-53.BJOG

Abstract

OBJECTIVE

The objective of this study was to investigate whether follicle stimulating hormone (FSH), anti-Mullerian hormone (AMH) and inhibin B could be useful in predicting the ovarian response to gonadotrophin stimulation in assisted reproduction patients who are considered to be poor responders.

DESIGN

Prospective study.

SETTING

Fertility unit.

SAMPLE

Blood samples were collected on day five or six in the early follicular phase of an untreated menstrual cycle. Samples were collected from 69 patients.

METHODS

Serum samples were assayed for FSH, AMH and inhibin B using commercial immunoassay kits.

MAIN OUTCOME MEASURES

Response to gonadotrophin stimulation and number of eggs collected.

RESULTS

Among the 69 patients, 52 patients completed an IVF cycle and 17 patients had to cancel the cycle because of poor ovarian response to gonadotrophin stimulation. Mean FSH levels were significantly higher (P < 0.05) in the cancelled group (10.69 +/- 2.27 mIU/mL) compared with the cycle-completed group (7.89 +/- 0.78 mIU/mL). Mean AMH levels were significantly lower (P < 0.01) in the cancelled group (0.175 +/- 0.04 ng/mL) compared with the cycle-completed group (1.13 +/- 0.2 ng/mL). Mean inhibin B levels were significantly lower (P < 0.001) in the cancelled group (70 +/- 12.79 pg/mL) compared with the completed group (126.9 +/- 8.8 pg/mL). Predictive statistics show that AMH is the best single marker and that the combination of FSH, AMH and inhibin B is modestly better than the single marker. Linear regression analysis in the cycle completed patients shows that although FSH (r= 0.25, P < 0.05) and inhibin B (r= 0.35, P < 0.05) have a significant linear association with the number of eggs collected, AMH has the greatest association (r= 0.69, P < 0.001) with the number of eggs collected among the parameters measured.

CONCLUSION

In this particular group of IVF patients, AMH is the best single marker of ovarian response to gonadotrophin stimulation. The combined markers modestly improved the prediction.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, RFUCL Medical School, University College London, 86-96 Chenies Mews, London WC1E 6HX, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15521870

Citation

Muttukrishna, Shanthi, et al. "Inhibin B and anti-Mullerian Hormone: Markers of Ovarian Response in IVF/ICSI Patients?" BJOG : an International Journal of Obstetrics and Gynaecology, vol. 111, no. 11, 2004, pp. 1248-53.
Muttukrishna S, Suharjono H, McGarrigle H, et al. Inhibin B and anti-Mullerian hormone: markers of ovarian response in IVF/ICSI patients? BJOG. 2004;111(11):1248-53.
Muttukrishna, S., Suharjono, H., McGarrigle, H., & Sathanandan, M. (2004). Inhibin B and anti-Mullerian hormone: markers of ovarian response in IVF/ICSI patients? BJOG : an International Journal of Obstetrics and Gynaecology, 111(11), 1248-53.
Muttukrishna S, et al. Inhibin B and anti-Mullerian Hormone: Markers of Ovarian Response in IVF/ICSI Patients. BJOG. 2004;111(11):1248-53. PubMed PMID: 15521870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibin B and anti-Mullerian hormone: markers of ovarian response in IVF/ICSI patients? AU - Muttukrishna,Shanthi, AU - Suharjono,Harris, AU - McGarrigle,Hugh, AU - Sathanandan,Muttukrishna, PY - 2004/11/4/pubmed PY - 2004/12/16/medline PY - 2004/11/4/entrez SP - 1248 EP - 53 JF - BJOG : an international journal of obstetrics and gynaecology JO - BJOG VL - 111 IS - 11 N2 - OBJECTIVE: The objective of this study was to investigate whether follicle stimulating hormone (FSH), anti-Mullerian hormone (AMH) and inhibin B could be useful in predicting the ovarian response to gonadotrophin stimulation in assisted reproduction patients who are considered to be poor responders. DESIGN: Prospective study. SETTING: Fertility unit. SAMPLE: Blood samples were collected on day five or six in the early follicular phase of an untreated menstrual cycle. Samples were collected from 69 patients. METHODS: Serum samples were assayed for FSH, AMH and inhibin B using commercial immunoassay kits. MAIN OUTCOME MEASURES: Response to gonadotrophin stimulation and number of eggs collected. RESULTS: Among the 69 patients, 52 patients completed an IVF cycle and 17 patients had to cancel the cycle because of poor ovarian response to gonadotrophin stimulation. Mean FSH levels were significantly higher (P < 0.05) in the cancelled group (10.69 +/- 2.27 mIU/mL) compared with the cycle-completed group (7.89 +/- 0.78 mIU/mL). Mean AMH levels were significantly lower (P < 0.01) in the cancelled group (0.175 +/- 0.04 ng/mL) compared with the cycle-completed group (1.13 +/- 0.2 ng/mL). Mean inhibin B levels were significantly lower (P < 0.001) in the cancelled group (70 +/- 12.79 pg/mL) compared with the completed group (126.9 +/- 8.8 pg/mL). Predictive statistics show that AMH is the best single marker and that the combination of FSH, AMH and inhibin B is modestly better than the single marker. Linear regression analysis in the cycle completed patients shows that although FSH (r= 0.25, P < 0.05) and inhibin B (r= 0.35, P < 0.05) have a significant linear association with the number of eggs collected, AMH has the greatest association (r= 0.69, P < 0.001) with the number of eggs collected among the parameters measured. CONCLUSION: In this particular group of IVF patients, AMH is the best single marker of ovarian response to gonadotrophin stimulation. The combined markers modestly improved the prediction. SN - 1470-0328 UR - https://www.unboundmedicine.com/medline/citation/15521870/Inhibin_B_and_anti_Mullerian_hormone:_markers_of_ovarian_response_in_IVF/ICSI_patients L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=1470-0328&amp;date=2004&amp;volume=111&amp;issue=11&amp;spage=1248 DB - PRIME DP - Unbound Medicine ER -