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Associations of insulin-like growth factors, insulin-like growth factor binding proteins and acid-labile subunit with coronary heart disease.
Clin Endocrinol (Oxf). 2004 Nov; 61(5):595-602.CE

Abstract

OBJECTIVE

IGFs and their binding proteins (IGFBPs) are produced both systemically and locally by cells of the cardiovascular system. As growth promoters, they may play a role in atherosclerosis.

DESIGN

Case-control, cross-sectional.

PATIENTS

A total of 95 nondiabetic male patients with coronary heart disease (CHD) and 92 probands from the Prospective Cardiovascular Munster (PROCAM) who were below the age of 60 years and matched by age, body mass index (BMI) and smoking habits.

MEASUREMENTS

We analysed the strength and independence of associations of angiographically assessed presence of CHD with BMI, systolic and diastolic blood pressure, total, high-density lipoprotein (HDL) and LDL cholesterol, triglycerides, lipoprotein(a), apolipoproteins A-I and B, total and free IGF-I, IGF-II, IGFBP-1, IGFBP-3, IGFBP-5, acid-labile subunit (ALS), insulin, C-peptide, testosterone, DHEAS and sex hormone binding globulin.

RESULTS

Using multivariate statistical analysis, the presence of CHD had significant positive associations with total IGF-I, IGFBP-5, ALS and IGFBP-3. These associations were independent of each other as well as of traditional risk factors, insulin and sex hormones.

CONCLUSION

These observations may indicate a pathogenetic role of the GH/IGF axis in coronary atherosclerosis.

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Authors+Show Affiliations

Fischer F
Institut für Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfälische Wilhelms-Universität Münster, Germany.
Schulte H
No affiliation info available
Mohan S
No affiliation info available
Tataru MC
No affiliation info available
Köhler E
No affiliation info available
Assmann G
No affiliation info available
von Eckardstein A
No affiliation info available

MeSH

C-PeptideCarrier ProteinsCase-Control StudiesCoronary AngiographyCoronary DiseaseCross-Sectional StudiesDehydroepiandrosterone SulfateGlycoproteinsHealth SurveysHumansInsulinInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Binding Protein 5Insulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor IInsulin-Like Growth Factor IIMaleMiddle AgedMultivariate AnalysisSex Hormone-Binding GlobulinSomatomedinsTestosterone

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15521962

Citation

Fischer, Frank, et al. "Associations of Insulin-like Growth Factors, Insulin-like Growth Factor Binding Proteins and Acid-labile Subunit With Coronary Heart Disease." Clinical Endocrinology, vol. 61, no. 5, 2004, pp. 595-602.
Fischer F, Schulte H, Mohan S, et al. Associations of insulin-like growth factors, insulin-like growth factor binding proteins and acid-labile subunit with coronary heart disease. Clin Endocrinol (Oxf). 2004;61(5):595-602.
Fischer, F., Schulte, H., Mohan, S., Tataru, M. C., Köhler, E., Assmann, G., & von Eckardstein, A. (2004). Associations of insulin-like growth factors, insulin-like growth factor binding proteins and acid-labile subunit with coronary heart disease. Clinical Endocrinology, 61(5), 595-602.
Fischer F, et al. Associations of Insulin-like Growth Factors, Insulin-like Growth Factor Binding Proteins and Acid-labile Subunit With Coronary Heart Disease. Clin Endocrinol (Oxf). 2004;61(5):595-602. PubMed PMID: 15521962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of insulin-like growth factors, insulin-like growth factor binding proteins and acid-labile subunit with coronary heart disease. AU - Fischer,Frank, AU - Schulte,Helmut, AU - Mohan,Subburaman, AU - Tataru,Mira-Christine, AU - Köhler,Ekkehart, AU - Assmann,Gerd, AU - von Eckardstein,Arnold, PY - 2004/11/4/pubmed PY - 2005/3/30/medline PY - 2004/11/4/entrez SP - 595 EP - 602 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 61 IS - 5 N2 - OBJECTIVE: IGFs and their binding proteins (IGFBPs) are produced both systemically and locally by cells of the cardiovascular system. As growth promoters, they may play a role in atherosclerosis. DESIGN: Case-control, cross-sectional. PATIENTS: A total of 95 nondiabetic male patients with coronary heart disease (CHD) and 92 probands from the Prospective Cardiovascular Munster (PROCAM) who were below the age of 60 years and matched by age, body mass index (BMI) and smoking habits. MEASUREMENTS: We analysed the strength and independence of associations of angiographically assessed presence of CHD with BMI, systolic and diastolic blood pressure, total, high-density lipoprotein (HDL) and LDL cholesterol, triglycerides, lipoprotein(a), apolipoproteins A-I and B, total and free IGF-I, IGF-II, IGFBP-1, IGFBP-3, IGFBP-5, acid-labile subunit (ALS), insulin, C-peptide, testosterone, DHEAS and sex hormone binding globulin. RESULTS: Using multivariate statistical analysis, the presence of CHD had significant positive associations with total IGF-I, IGFBP-5, ALS and IGFBP-3. These associations were independent of each other as well as of traditional risk factors, insulin and sex hormones. CONCLUSION: These observations may indicate a pathogenetic role of the GH/IGF axis in coronary atherosclerosis. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/15521962/Associations_of_insulin_like_growth_factors_insulin_like_growth_factor_binding_proteins_and_acid_labile_subunit_with_coronary_heart_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0300-0664&date=2004&volume=61&issue=5&spage=595 DB - PRIME DP - Unbound Medicine ER -