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Protective role of Scoparia dulcis plant extract on brain antioxidant status and lipidperoxidation in STZ diabetic male Wistar rats.
BMC Complement Altern Med. 2004 Nov 02; 4:16.BC

Abstract

BACKGROUND

The aim of the study was to investigate the effect of aqueous extract of Scoparia dulcis on the occurrence of oxidative stress in the brain of rats during diabetes by measuring the extent of oxidative damage as well as the status of the antioxidant defense system.

METHODS

Aqueous extract of Scoparia dulcis plant was administered orally (200 mg/kg body weight) and the effect of extract on blood glucose, plasma insulin and the levels of thiobarbituric acid reactive substances (TBARS), hydroperoxides, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and reduced glutathione (GSH) were estimated in streptozotocin (STZ) induced diabetic rats. Glibenclamide was used as standard reference drug.

RESULTS

A significant increase in the activities of plasma insulin, superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and reduced glutathione was observed in brain on treatment with 200 mg/kg body weight of Scoparia dulcis plant extract (SPEt) and glibenclamide for 6 weeks. Both the treated groups showed significant decrease in TBARS and hydroperoxides formation in brain, suggesting its role in protection against lipidperoxidation induced membrane damage.

CONCLUSIONS

Since the study of induction of the antioxidant enzymes is considered to be a reliable marker for evaluating the antiperoxidative efficacy of the medicinal plant, these findings suggest a possible antiperoxidative role for Scoparia dulcis plant extract. Hence, in addition to antidiabetic effect, Scoparia dulcis possess antioxidant potential that may be used for therapeutic purposes.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu-608 002, India. paribala@sancharnet.inNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15522116

Citation

Pari, Leelavinothan, and Muniappan Latha. "Protective Role of Scoparia Dulcis Plant Extract On Brain Antioxidant Status and Lipidperoxidation in STZ Diabetic Male Wistar Rats." BMC Complementary and Alternative Medicine, vol. 4, 2004, p. 16.
Pari L, Latha M. Protective role of Scoparia dulcis plant extract on brain antioxidant status and lipidperoxidation in STZ diabetic male Wistar rats. BMC Complement Altern Med. 2004;4:16.
Pari, L., & Latha, M. (2004). Protective role of Scoparia dulcis plant extract on brain antioxidant status and lipidperoxidation in STZ diabetic male Wistar rats. BMC Complementary and Alternative Medicine, 4, 16.
Pari L, Latha M. Protective Role of Scoparia Dulcis Plant Extract On Brain Antioxidant Status and Lipidperoxidation in STZ Diabetic Male Wistar Rats. BMC Complement Altern Med. 2004 Nov 2;4:16. PubMed PMID: 15522116.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective role of Scoparia dulcis plant extract on brain antioxidant status and lipidperoxidation in STZ diabetic male Wistar rats. AU - Pari,Leelavinothan, AU - Latha,Muniappan, Y1 - 2004/11/02/ PY - 2004/06/04/received PY - 2004/11/02/accepted PY - 2004/11/4/pubmed PY - 2005/3/23/medline PY - 2004/11/4/entrez SP - 16 EP - 16 JF - BMC complementary and alternative medicine JO - BMC Complement Altern Med VL - 4 N2 - BACKGROUND: The aim of the study was to investigate the effect of aqueous extract of Scoparia dulcis on the occurrence of oxidative stress in the brain of rats during diabetes by measuring the extent of oxidative damage as well as the status of the antioxidant defense system. METHODS: Aqueous extract of Scoparia dulcis plant was administered orally (200 mg/kg body weight) and the effect of extract on blood glucose, plasma insulin and the levels of thiobarbituric acid reactive substances (TBARS), hydroperoxides, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and reduced glutathione (GSH) were estimated in streptozotocin (STZ) induced diabetic rats. Glibenclamide was used as standard reference drug. RESULTS: A significant increase in the activities of plasma insulin, superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and reduced glutathione was observed in brain on treatment with 200 mg/kg body weight of Scoparia dulcis plant extract (SPEt) and glibenclamide for 6 weeks. Both the treated groups showed significant decrease in TBARS and hydroperoxides formation in brain, suggesting its role in protection against lipidperoxidation induced membrane damage. CONCLUSIONS: Since the study of induction of the antioxidant enzymes is considered to be a reliable marker for evaluating the antiperoxidative efficacy of the medicinal plant, these findings suggest a possible antiperoxidative role for Scoparia dulcis plant extract. Hence, in addition to antidiabetic effect, Scoparia dulcis possess antioxidant potential that may be used for therapeutic purposes. SN - 1472-6882 UR - https://www.unboundmedicine.com/medline/citation/15522116/Protective_role_of_Scoparia_dulcis_plant_extract_on_brain_antioxidant_status_and_lipidperoxidation_in_STZ_diabetic_male_Wistar_rats_ L2 - https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-4-16 DB - PRIME DP - Unbound Medicine ER -