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Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair.
Ophthalmology 2004; 111(11):2033-43O

Abstract

PURPOSE

To compare ultrahigh-resolution optical coherence tomography (UHR-OCT) technology to a standard-resolution OCT instrument for the imaging of macular hole pathology and repair; to identify situations where UHR-OCT provides additional information on disease morphology, pathogenesis, and management; and to use UHR-OCT as a baseline for improving the interpretation of the standard-resolution images.

DESIGN

Observational and interventional case series.

PARTICIPANTS

Twenty-nine eyes of 24 patients clinically diagnosed with macular hole in at least one eye.

METHODS

A UHR-OCT system has been developed and employed in a tertiary-care ophthalmology clinic. Using a femtosecond laser as the low-coherence light source, this new UHR-OCT system can achieve an unprecedented 3-mum axial resolution for retinal OCT imaging. Comparative imaging was performed with UHR-OCT and standard 10-mum resolution OCT in 29 eyes of 24 patients with various stages of macular holes. Imaging was also performed on a subset of the population before and after macular hole surgery.

MAIN OUTCOME MEASURES

Ultrahigh- and standard-resolution cross-sectional OCT images of macular hole pathologies.

RESULTS

Both UHR-OCT and standard-resolution OCT exhibited comparable performance in differentiating various stages of macular holes. The UHR-OCT provided improved imaging of finer intraretinal structures, such as the external limiting membrane and photoreceptor inner segment (IS) and outer segment (OS), and identification of the anatomy of successful surgical repair. The improved resolution of UHR-OCT enabled imaging of previously unidentified changes in photoreceptor morphology associated with macular hole pathology and postoperative repair. Visualization of the junction between the photoreceptor IS and OS was found to be an important indicator of photoreceptor integrity for both standard-resolution and UHR-OCT images.

CONCLUSIONS

Ultrahigh-resolution optical coherence tomography improves the visualization of the macular hole architectural morphology. The increased resolution of UHR-OCT enables the visualization of photoreceptor morphology associated with macular holes. This promises to lead to a better understanding of the pathogenesis of macular holes, the causes of visual loss secondary to macular holes, the timing of surgical repair, and the evaluation of postsurgical outcome. Ultrahigh-resolution optical coherence tomography imaging of macular holes that correspond to known alterations in retinal morphology can be used to interpret retinal morphology in UHR-OCT images. Comparisons of UHR-OCT images with standard-resolution OCT images can establish a baseline for the better interpretation of clinical standard-resolution OCT images. The ability to visualize photoreceptors and their integrity or impairment is an indicator of macular hole progression and surgical outcome.

Authors+Show Affiliations

Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15522369

Citation

Ko, Tony H., et al. "Comparison of Ultrahigh- and Standard-resolution Optical Coherence Tomography for Imaging Macular Hole Pathology and Repair." Ophthalmology, vol. 111, no. 11, 2004, pp. 2033-43.
Ko TH, Fujimoto JG, Duker JS, et al. Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair. Ophthalmology. 2004;111(11):2033-43.
Ko, T. H., Fujimoto, J. G., Duker, J. S., Paunescu, L. A., Drexler, W., Baumal, C. R., ... Schuman, J. S. (2004). Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair. Ophthalmology, 111(11), pp. 2033-43.
Ko TH, et al. Comparison of Ultrahigh- and Standard-resolution Optical Coherence Tomography for Imaging Macular Hole Pathology and Repair. Ophthalmology. 2004;111(11):2033-43. PubMed PMID: 15522369.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair. AU - Ko,Tony H, AU - Fujimoto,James G, AU - Duker,Jay S, AU - Paunescu,Lelia A, AU - Drexler,Wolfgang, AU - Baumal,Caroline R, AU - Puliafito,Carmen A, AU - Reichel,Elias, AU - Rogers,Adam H, AU - Schuman,Joel S, PY - 2003/11/07/received PY - 2004/05/10/accepted PY - 2004/11/4/pubmed PY - 2004/12/16/medline PY - 2004/11/4/entrez SP - 2033 EP - 43 JF - Ophthalmology JO - Ophthalmology VL - 111 IS - 11 N2 - PURPOSE: To compare ultrahigh-resolution optical coherence tomography (UHR-OCT) technology to a standard-resolution OCT instrument for the imaging of macular hole pathology and repair; to identify situations where UHR-OCT provides additional information on disease morphology, pathogenesis, and management; and to use UHR-OCT as a baseline for improving the interpretation of the standard-resolution images. DESIGN: Observational and interventional case series. PARTICIPANTS: Twenty-nine eyes of 24 patients clinically diagnosed with macular hole in at least one eye. METHODS: A UHR-OCT system has been developed and employed in a tertiary-care ophthalmology clinic. Using a femtosecond laser as the low-coherence light source, this new UHR-OCT system can achieve an unprecedented 3-mum axial resolution for retinal OCT imaging. Comparative imaging was performed with UHR-OCT and standard 10-mum resolution OCT in 29 eyes of 24 patients with various stages of macular holes. Imaging was also performed on a subset of the population before and after macular hole surgery. MAIN OUTCOME MEASURES: Ultrahigh- and standard-resolution cross-sectional OCT images of macular hole pathologies. RESULTS: Both UHR-OCT and standard-resolution OCT exhibited comparable performance in differentiating various stages of macular holes. The UHR-OCT provided improved imaging of finer intraretinal structures, such as the external limiting membrane and photoreceptor inner segment (IS) and outer segment (OS), and identification of the anatomy of successful surgical repair. The improved resolution of UHR-OCT enabled imaging of previously unidentified changes in photoreceptor morphology associated with macular hole pathology and postoperative repair. Visualization of the junction between the photoreceptor IS and OS was found to be an important indicator of photoreceptor integrity for both standard-resolution and UHR-OCT images. CONCLUSIONS: Ultrahigh-resolution optical coherence tomography improves the visualization of the macular hole architectural morphology. The increased resolution of UHR-OCT enables the visualization of photoreceptor morphology associated with macular holes. This promises to lead to a better understanding of the pathogenesis of macular holes, the causes of visual loss secondary to macular holes, the timing of surgical repair, and the evaluation of postsurgical outcome. Ultrahigh-resolution optical coherence tomography imaging of macular holes that correspond to known alterations in retinal morphology can be used to interpret retinal morphology in UHR-OCT images. Comparisons of UHR-OCT images with standard-resolution OCT images can establish a baseline for the better interpretation of clinical standard-resolution OCT images. The ability to visualize photoreceptors and their integrity or impairment is an indicator of macular hole progression and surgical outcome. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/15522369/Comparison_of_ultrahigh__and_standard_resolution_optical_coherence_tomography_for_imaging_macular_hole_pathology_and_repair_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(04)00832-2 DB - PRIME DP - Unbound Medicine ER -