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A prospective cohort study of nut consumption and the risk of gallstone disease in men.
Am J Epidemiol 2004; 160(10):961-8AJ

Abstract

Gallstone disease is a major source of morbidity in Western countries. Nuts are rich in several compounds that may be protective against gallstones. The objective of the study was to examine the relation between nut consumption and gallstone disease in the Health Professionals Follow-up Study. The consumption of nuts was assessed starting in 1986 as part of a 131-item semiquantitative food frequency questionnaire. The main outcome measure was newly diagnosed symptomatic gallstones. During 457,305 person-years of follow-up, 1,833 participants reported gallstone disease. After adjustment for age and other known or suspected risk factors, men consuming 5 or more units of nuts per week (frequent consumption) had a significantly lower risk of gallstone disease (relative risk = 0.70, 95% confidence interval: 0.60, 0.86; p(trend) < 0.001) than did men who never ate or who ate less than 1 unit per month (rare consumption) (1 unit = 1 ounce (0.028 kg) of nuts). Further adjustment for fat consumption (saturated fat, trans-fat, polyunsaturated fat, and monounsaturated fat) did not materially alter the relation. In analyses examining consumption of peanuts and other nuts separately, both were significantly associated with a lower risk of gallstone disease in the age-adjusted and multivariate models. Our findings suggest that frequent nut consumption is associated with a reduced risk of gallstone disease in men.

Authors+Show Affiliations

Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. hpcjt@channing.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15522852

Citation

Tsai, Chung-Jyi, et al. "A Prospective Cohort Study of Nut Consumption and the Risk of Gallstone Disease in Men." American Journal of Epidemiology, vol. 160, no. 10, 2004, pp. 961-8.
Tsai CJ, Leitzmann MF, Hu FB, et al. A prospective cohort study of nut consumption and the risk of gallstone disease in men. Am J Epidemiol. 2004;160(10):961-8.
Tsai, C. J., Leitzmann, M. F., Hu, F. B., Willett, W. C., & Giovannucci, E. L. (2004). A prospective cohort study of nut consumption and the risk of gallstone disease in men. American Journal of Epidemiology, 160(10), pp. 961-8.
Tsai CJ, et al. A Prospective Cohort Study of Nut Consumption and the Risk of Gallstone Disease in Men. Am J Epidemiol. 2004 Nov 15;160(10):961-8. PubMed PMID: 15522852.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective cohort study of nut consumption and the risk of gallstone disease in men. AU - Tsai,Chung-Jyi, AU - Leitzmann,Michael F, AU - Hu,Frank B, AU - Willett,Walter C, AU - Giovannucci,Edward L, PY - 2004/11/4/pubmed PY - 2004/12/16/medline PY - 2004/11/4/entrez SP - 961 EP - 8 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 160 IS - 10 N2 - Gallstone disease is a major source of morbidity in Western countries. Nuts are rich in several compounds that may be protective against gallstones. The objective of the study was to examine the relation between nut consumption and gallstone disease in the Health Professionals Follow-up Study. The consumption of nuts was assessed starting in 1986 as part of a 131-item semiquantitative food frequency questionnaire. The main outcome measure was newly diagnosed symptomatic gallstones. During 457,305 person-years of follow-up, 1,833 participants reported gallstone disease. After adjustment for age and other known or suspected risk factors, men consuming 5 or more units of nuts per week (frequent consumption) had a significantly lower risk of gallstone disease (relative risk = 0.70, 95% confidence interval: 0.60, 0.86; p(trend) < 0.001) than did men who never ate or who ate less than 1 unit per month (rare consumption) (1 unit = 1 ounce (0.028 kg) of nuts). Further adjustment for fat consumption (saturated fat, trans-fat, polyunsaturated fat, and monounsaturated fat) did not materially alter the relation. In analyses examining consumption of peanuts and other nuts separately, both were significantly associated with a lower risk of gallstone disease in the age-adjusted and multivariate models. Our findings suggest that frequent nut consumption is associated with a reduced risk of gallstone disease in men. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/15522852/A_prospective_cohort_study_of_nut_consumption_and_the_risk_of_gallstone_disease_in_men_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwh302 DB - PRIME DP - Unbound Medicine ER -