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Coffee consumption, gender, and Parkinson's disease mortality in the cancer prevention study II cohort: the modifying effects of estrogen.
Am J Epidemiol. 2004 Nov 15; 160(10):977-84.AJ

Abstract

Caffeine consumption is associated with a reduced risk of Parkinson's disease in men but not in women. This gender difference may be due to an interaction between caffeine and use of postmenopausal estrogens. The authors prospectively assessed the relation between coffee consumption and Parkinson's disease mortality among participants in the Cancer Prevention Study II, a cohort of over 1 million people enrolled in 1982. Causes of deaths were ascertained through death certificates from January 1, 1989, through 1998. Parkinson's disease was listed as a cause of death in 909 men and 340 women. After adjustment for age, smoking, and alcohol intake, coffee consumption was inversely associated with Parkinson's disease mortality in men (p(trend) = 0.01) but not in women (p = 0.6). In women, this association was dependent on postmenopausal estrogen use; the relative risk for women drinking 4 or more cups (600 ml) of coffee per day compared with nondrinkers was 0.47 (95% confidence interval: 0.27, 0.80; p = 0.006) among never users and 1.31 (95% confidence interval: 0.75, 2.30; p = 0.34) among users. These results suggest that caffeine reduces the risk of Parkinson's disease but that this hypothetical beneficial effect may be prevented by use of estrogen replacement therapy.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. aascheri@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15522854

Citation

Ascherio, Alberto, et al. "Coffee Consumption, Gender, and Parkinson's Disease Mortality in the Cancer Prevention Study II Cohort: the Modifying Effects of Estrogen." American Journal of Epidemiology, vol. 160, no. 10, 2004, pp. 977-84.
Ascherio A, Weisskopf MG, O'Reilly EJ, et al. Coffee consumption, gender, and Parkinson's disease mortality in the cancer prevention study II cohort: the modifying effects of estrogen. Am J Epidemiol. 2004;160(10):977-84.
Ascherio, A., Weisskopf, M. G., O'Reilly, E. J., McCullough, M. L., Calle, E. E., Rodriguez, C., & Thun, M. J. (2004). Coffee consumption, gender, and Parkinson's disease mortality in the cancer prevention study II cohort: the modifying effects of estrogen. American Journal of Epidemiology, 160(10), 977-84.
Ascherio A, et al. Coffee Consumption, Gender, and Parkinson's Disease Mortality in the Cancer Prevention Study II Cohort: the Modifying Effects of Estrogen. Am J Epidemiol. 2004 Nov 15;160(10):977-84. PubMed PMID: 15522854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee consumption, gender, and Parkinson's disease mortality in the cancer prevention study II cohort: the modifying effects of estrogen. AU - Ascherio,Alberto, AU - Weisskopf,Marc G, AU - O'Reilly,Eilis J, AU - McCullough,Marjorie L, AU - Calle,Eugenia E, AU - Rodriguez,Carmen, AU - Thun,Michael J, PY - 2004/11/4/pubmed PY - 2004/12/16/medline PY - 2004/11/4/entrez SP - 977 EP - 84 JF - American journal of epidemiology JO - Am J Epidemiol VL - 160 IS - 10 N2 - Caffeine consumption is associated with a reduced risk of Parkinson's disease in men but not in women. This gender difference may be due to an interaction between caffeine and use of postmenopausal estrogens. The authors prospectively assessed the relation between coffee consumption and Parkinson's disease mortality among participants in the Cancer Prevention Study II, a cohort of over 1 million people enrolled in 1982. Causes of deaths were ascertained through death certificates from January 1, 1989, through 1998. Parkinson's disease was listed as a cause of death in 909 men and 340 women. After adjustment for age, smoking, and alcohol intake, coffee consumption was inversely associated with Parkinson's disease mortality in men (p(trend) = 0.01) but not in women (p = 0.6). In women, this association was dependent on postmenopausal estrogen use; the relative risk for women drinking 4 or more cups (600 ml) of coffee per day compared with nondrinkers was 0.47 (95% confidence interval: 0.27, 0.80; p = 0.006) among never users and 1.31 (95% confidence interval: 0.75, 2.30; p = 0.34) among users. These results suggest that caffeine reduces the risk of Parkinson's disease but that this hypothetical beneficial effect may be prevented by use of estrogen replacement therapy. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/15522854/Coffee_consumption_gender_and_Parkinson's_disease_mortality_in_the_cancer_prevention_study_II_cohort:_the_modifying_effects_of_estrogen_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwh312 DB - PRIME DP - Unbound Medicine ER -