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Fish intake, marine omega-3 fatty acids, and mortality in a cohort of postmenopausal women.
Am J Epidemiol. 2004 Nov 15; 160(10):1005-10.AJ

Abstract

Intake of fish or omega-3 fatty acids may decrease risk of total and coronary heart disease death, but evidence from low-risk populations is less convincing. The authors assessed intake by using a food frequency questionnaire at baseline in a cohort of Iowa women aged 55-69 years. Among women initially free of heart disease and cancer (4,653 deaths over 442,965 person-years), there was an inverse age- and energy-adjusted association between total mortality and fish intake, with a relative risk of 0.82 (95% confidence interval: 0.74, 0.91) for the highest versus lowest quintile. Age- and energy-adjusted associations also were inverse (p for trend < 0.05), although not entirely monotonic, for cardiovascular, coronary heart disease, and cancer mortality. Adjustment for multiple other risk factors attenuated all associations to statistically nonsignificant levels. Estimated marine omega-3 fatty acid intake also was not associated with total or cause-specific mortality. In comparison, plant-derived alpha-linolenic acid was inversely associated with mortality after multivariable adjustment. Intake of neither fish nor marine omega-3 fatty acids was associated with breast cancer incidence. These findings do not argue against recommending fish as part of a healthy diet, as other evidence suggests benefit. Nevertheless, the authors of this 1986-2000 study could not verify that fish and marine omega-3 fatty acid intake had independent health benefits in these postmenopausal women.

Authors+Show Affiliations

Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454-1015, USA. folsom@epi.umn.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15522857

Citation

Folsom, Aaron R., and Zewditu Demissie. "Fish Intake, Marine Omega-3 Fatty Acids, and Mortality in a Cohort of Postmenopausal Women." American Journal of Epidemiology, vol. 160, no. 10, 2004, pp. 1005-10.
Folsom AR, Demissie Z. Fish intake, marine omega-3 fatty acids, and mortality in a cohort of postmenopausal women. Am J Epidemiol. 2004;160(10):1005-10.
Folsom, A. R., & Demissie, Z. (2004). Fish intake, marine omega-3 fatty acids, and mortality in a cohort of postmenopausal women. American Journal of Epidemiology, 160(10), 1005-10.
Folsom AR, Demissie Z. Fish Intake, Marine Omega-3 Fatty Acids, and Mortality in a Cohort of Postmenopausal Women. Am J Epidemiol. 2004 Nov 15;160(10):1005-10. PubMed PMID: 15522857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fish intake, marine omega-3 fatty acids, and mortality in a cohort of postmenopausal women. AU - Folsom,Aaron R, AU - Demissie,Zewditu, PY - 2004/11/4/pubmed PY - 2004/12/16/medline PY - 2004/11/4/entrez SP - 1005 EP - 10 JF - American journal of epidemiology JO - Am J Epidemiol VL - 160 IS - 10 N2 - Intake of fish or omega-3 fatty acids may decrease risk of total and coronary heart disease death, but evidence from low-risk populations is less convincing. The authors assessed intake by using a food frequency questionnaire at baseline in a cohort of Iowa women aged 55-69 years. Among women initially free of heart disease and cancer (4,653 deaths over 442,965 person-years), there was an inverse age- and energy-adjusted association between total mortality and fish intake, with a relative risk of 0.82 (95% confidence interval: 0.74, 0.91) for the highest versus lowest quintile. Age- and energy-adjusted associations also were inverse (p for trend < 0.05), although not entirely monotonic, for cardiovascular, coronary heart disease, and cancer mortality. Adjustment for multiple other risk factors attenuated all associations to statistically nonsignificant levels. Estimated marine omega-3 fatty acid intake also was not associated with total or cause-specific mortality. In comparison, plant-derived alpha-linolenic acid was inversely associated with mortality after multivariable adjustment. Intake of neither fish nor marine omega-3 fatty acids was associated with breast cancer incidence. These findings do not argue against recommending fish as part of a healthy diet, as other evidence suggests benefit. Nevertheless, the authors of this 1986-2000 study could not verify that fish and marine omega-3 fatty acid intake had independent health benefits in these postmenopausal women. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/15522857/Fish_intake_marine_omega_3_fatty_acids_and_mortality_in_a_cohort_of_postmenopausal_women_ DB - PRIME DP - Unbound Medicine ER -