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Fasting unmasks a strong inverse association between ghrelin and cortisol in serum: studies in obese and normal-weight subjects.
J Clin Endocrinol Metab. 2005 Feb; 90(2):741-6.JC

Abstract

Administration of ghrelin, the endogenous ligand for the GH secretagogue receptor, stimulates not only GH secretion but also appetite and food intake in humans. Endogenous ghrelin levels display a distinct circadian rhythm, which is reciprocal to that of insulin and presumed to be meal dependent and not associated with GH secretion. We tested the hypothesis that food deprivation could impact circadian serum ghrelin levels and unmask meal-independent regulatory mechanisms. Thirty-three young adults, subdivided according to gender and level of obesity, were studied with blood sampling every 3 h from 12-84 h of fasting. Serum ghrelin levels showed a marked diurnal rhythm with a nadir in the morning (0800 h), peak levels in the afternoon, and a gradual decline during the night. This pattern was preserved during the entire fasting period and was independent of gender and obesity. Mean 24-h ghrelin levels exhibited a small but significant decline during the fast (P < 0.001). As expected, GH secretion increased with fasting in lean subjects, and a gradual decline in insulin concentrations was observed in all subjects. Neither GH nor insulin showed any significant relationship to ghrelin. In contrast, serum cortisol exhibited a strong inverse temporal association with ghrelin (r = -0.79; P < 0.0001). In conclusion, our study yields no evidence that ghrelin stimulates GH release during fasting. As a novel finding, ghrelin appears to be related to cortisol. However, further studies are needed to elucidate the physiological mechanisms behind this relationship.

Authors+Show Affiliations

Medical Research Laboratories, Aarhus University Hospital, Nørrebrogade 44, DK-8000 Aarhus C, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15522942

Citation

Espelund, Ulrick, et al. "Fasting Unmasks a Strong Inverse Association Between Ghrelin and Cortisol in Serum: Studies in Obese and Normal-weight Subjects." The Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 2, 2005, pp. 741-6.
Espelund U, Hansen TK, Højlund K, et al. Fasting unmasks a strong inverse association between ghrelin and cortisol in serum: studies in obese and normal-weight subjects. J Clin Endocrinol Metab. 2005;90(2):741-6.
Espelund, U., Hansen, T. K., Højlund, K., Beck-Nielsen, H., Clausen, J. T., Hansen, B. S., Orskov, H., Jørgensen, J. O., & Frystyk, J. (2005). Fasting unmasks a strong inverse association between ghrelin and cortisol in serum: studies in obese and normal-weight subjects. The Journal of Clinical Endocrinology and Metabolism, 90(2), 741-6.
Espelund U, et al. Fasting Unmasks a Strong Inverse Association Between Ghrelin and Cortisol in Serum: Studies in Obese and Normal-weight Subjects. J Clin Endocrinol Metab. 2005;90(2):741-6. PubMed PMID: 15522942.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fasting unmasks a strong inverse association between ghrelin and cortisol in serum: studies in obese and normal-weight subjects. AU - Espelund,Ulrick, AU - Hansen,Troels Krarup, AU - Højlund,Kurt, AU - Beck-Nielsen,Henning, AU - Clausen,Jes Thorn, AU - Hansen,Birgit Sehested, AU - Orskov,Hans, AU - Jørgensen,Jens Otto Lunde, AU - Frystyk,Jan, Y1 - 2004/11/02/ PY - 2004/11/4/pubmed PY - 2005/3/25/medline PY - 2004/11/4/entrez SP - 741 EP - 6 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 90 IS - 2 N2 - Administration of ghrelin, the endogenous ligand for the GH secretagogue receptor, stimulates not only GH secretion but also appetite and food intake in humans. Endogenous ghrelin levels display a distinct circadian rhythm, which is reciprocal to that of insulin and presumed to be meal dependent and not associated with GH secretion. We tested the hypothesis that food deprivation could impact circadian serum ghrelin levels and unmask meal-independent regulatory mechanisms. Thirty-three young adults, subdivided according to gender and level of obesity, were studied with blood sampling every 3 h from 12-84 h of fasting. Serum ghrelin levels showed a marked diurnal rhythm with a nadir in the morning (0800 h), peak levels in the afternoon, and a gradual decline during the night. This pattern was preserved during the entire fasting period and was independent of gender and obesity. Mean 24-h ghrelin levels exhibited a small but significant decline during the fast (P < 0.001). As expected, GH secretion increased with fasting in lean subjects, and a gradual decline in insulin concentrations was observed in all subjects. Neither GH nor insulin showed any significant relationship to ghrelin. In contrast, serum cortisol exhibited a strong inverse temporal association with ghrelin (r = -0.79; P < 0.0001). In conclusion, our study yields no evidence that ghrelin stimulates GH release during fasting. As a novel finding, ghrelin appears to be related to cortisol. However, further studies are needed to elucidate the physiological mechanisms behind this relationship. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/15522942/Fasting_unmasks_a_strong_inverse_association_between_ghrelin_and_cortisol_in_serum:_studies_in_obese_and_normal_weight_subjects_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2004-0604 DB - PRIME DP - Unbound Medicine ER -