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Erythrocyte sickling during exercise and thermal stress.
Clin J Sport Med. 2004 Nov; 14(6):354-6.CJ

Abstract

OBJECTIVE

To examine effects of exercise in the heat and fluid intake on erythrocyte sickling and neutrophil activation in carriers of sickle cell trait (HbAS).

DESIGN, SETTING, AND PARTICIPANTS

Six African American men (2 HbAS; 42% HbS, 4 HbAA; 20.7 +/- 0.8 years; 87.4 +/- 9.6 kg) participated in 2 randomized sessions (separate days) each consisting of 45 minutes of brisk walking (treadmill) in a hot (33 degrees C) environment.

INTERVENTION

Subjects consumed no fluids or fluid for 3 hours prior to (ad libitum) and during (1.02 L) testing.

MAIN OUTCOME MEASUREMENTS

Core temperature, heart rate, and perceived exertion were measured. Forearm venous blood was analyzed for percent erythrocyte sickling and plasma myeloperoxidase.

RESULTS

Time-averaged heart rate (126.6 +/- 5.7 vs. 146.7 +/- 5.9 bpm; P = 0.02) and core temperature (37.6 +/- 0.1 vs. 38.1 +/- 0.1 degrees C; P < 0.05) responses were lower during fluid versus no fluid, with no statistically significant difference in perceived exertion (12.3 +/- 0.5 vs. 13.6 +/- 0.4; P = 0.06). Erythrocyte sickling progressively increased (to 3.5%-5.5%) for HbAS carriers during no fluid exercise only. No sickling was detected in HbAA subjects. Plasma myeloperoxidase responses to exercise were greater (P = 0.03) in HbAS versus HbAA.

CONCLUSIONS

Fluid ingestion at a rate sufficient to offset a body weight deficit can effectively reduce erythrocyte sickling during exercise in the heat.

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Authors+Show Affiliations

Bergeron MF
Department of Physical Therapy, Medical College of Georgia, Augusta, GA 30912-0800, USA. mbergero@mcg.edu
Cannon JG
No affiliation info available
Hall EL
No affiliation info available
Kutlar A
No affiliation info available

MeSH

AdultAfrican AmericansBody Temperature RegulationCase-Control StudiesErythrocytes, AbnormalExerciseHeart RateHeterozygoteHot TemperatureHumansMaleOxygen ConsumptionPhysical EndurancePhysical ExertionReference ValuesRisk AssessmentSensitivity and SpecificitySickle Cell TraitStress, Physiological

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15523207

Clinical Trial Links

Sickle Cell Trait and Exercise, Effect of Hot Environment

Citation

Bergeron, Michael F., et al. "Erythrocyte Sickling During Exercise and Thermal Stress." Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine, vol. 14, no. 6, 2004, pp. 354-6.
Bergeron MF, Cannon JG, Hall EL, et al. Erythrocyte sickling during exercise and thermal stress. Clin J Sport Med. 2004;14(6):354-6.
Bergeron, M. F., Cannon, J. G., Hall, E. L., & Kutlar, A. (2004). Erythrocyte sickling during exercise and thermal stress. Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine, 14(6), 354-6.
Bergeron MF, et al. Erythrocyte Sickling During Exercise and Thermal Stress. Clin J Sport Med. 2004;14(6):354-6. PubMed PMID: 15523207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Erythrocyte sickling during exercise and thermal stress. AU - Bergeron,Michael F, AU - Cannon,Joseph G, AU - Hall,Elaina L, AU - Kutlar,Abdullah, PY - 2004/11/4/pubmed PY - 2005/3/23/medline PY - 2004/11/4/entrez SP - 354 EP - 6 JF - Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine JO - Clin J Sport Med VL - 14 IS - 6 N2 - OBJECTIVE: To examine effects of exercise in the heat and fluid intake on erythrocyte sickling and neutrophil activation in carriers of sickle cell trait (HbAS). DESIGN, SETTING, AND PARTICIPANTS: Six African American men (2 HbAS; 42% HbS, 4 HbAA; 20.7 +/- 0.8 years; 87.4 +/- 9.6 kg) participated in 2 randomized sessions (separate days) each consisting of 45 minutes of brisk walking (treadmill) in a hot (33 degrees C) environment. INTERVENTION: Subjects consumed no fluids or fluid for 3 hours prior to (ad libitum) and during (1.02 L) testing. MAIN OUTCOME MEASUREMENTS: Core temperature, heart rate, and perceived exertion were measured. Forearm venous blood was analyzed for percent erythrocyte sickling and plasma myeloperoxidase. RESULTS: Time-averaged heart rate (126.6 +/- 5.7 vs. 146.7 +/- 5.9 bpm; P = 0.02) and core temperature (37.6 +/- 0.1 vs. 38.1 +/- 0.1 degrees C; P < 0.05) responses were lower during fluid versus no fluid, with no statistically significant difference in perceived exertion (12.3 +/- 0.5 vs. 13.6 +/- 0.4; P = 0.06). Erythrocyte sickling progressively increased (to 3.5%-5.5%) for HbAS carriers during no fluid exercise only. No sickling was detected in HbAA subjects. Plasma myeloperoxidase responses to exercise were greater (P = 0.03) in HbAS versus HbAA. CONCLUSIONS: Fluid ingestion at a rate sufficient to offset a body weight deficit can effectively reduce erythrocyte sickling during exercise in the heat. SN - 1050-642X UR - https://www.unboundmedicine.com/medline/citation/15523207/full_citation L2 - https://doi.org/10.1097/00042752-200411000-00005 DB - PRIME DP - Unbound Medicine ER -