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Cardiac mass and function, carotid artery intima media thickness, homocysteine and lipoprotein levels in children and adolescents with growth hormone deficiency.
J Pediatr Endocrinol Metab. 2004 Oct; 17(10):1405-13.JP

Abstract

INTRODUCTION

Early atheromatic changes have been found in the carotid and the femoral arteries of young adults with growth hormone (GH) deficiency (GHD). It has been shown that adults with GHD have increased cardiovascular risk factors. The aim of this study was to compare atherosclerotic risk factors in children with GHD and a normal population.

PATIENTS AND METHODS

Twenty-five patients (10 girls, 15 boys) with GHD qualified for GH replacement treatment were included in the study. The control group consisted of 22 healthy children (11 girls, 11 boys) with no family history of atherosclerosis and cardiovascular disease. Cardiac mass and function was evaluated by one-dimensional, two-dimensional echocardiography and the Doppler method. Common carotid intima-media thickness was measured with a linear probe (7.5 MHz). Lipid metabolism parameters (total cholesterol, HDL- and LDL-cholesterol, triglycerides), lipoprotein A (Lp(a)) and homocysteine levels were measured.

RESULTS

Cardiac dimensions and systolic parameters were within normal values in both groups. The mean index of left ventricular mass (68.37 +/- 18.64 g/m2) in patients with GHD did not differ significantly compared to controls (68.48 +/- 15.56 g/m2). No significant differences between the study and control group were observed when comparing systolic and ejection fraction values. Significantly higher mean values of IVRT parameter were found (70.8 +/- 14.2 ms vs 64.09 +/- 8.54% ms; p < 0.05). Other parameters characterizing systolic function were not significantly different. The mean concentration of total (178.28 +/- 31.1 mg/dl) and LDL-cholesterol (106 +/- 28.68 mg/dl) was significantly higher in patients with GHD than in controls (157.59 +/- 22.39 mg/dl, 84.54 +/- 22.01 mg/dl; p <0.05). Lp(a) (40.34 +/- 12.45 mg/dl vs 11.02 +/- 4.82 mg/dl; p <0.05) and apolipoprotein B (ApoB) (71.12 +/- 18 mg/dl vs 56.72 +/- 11.46 mg/dl; p < 0.05) were significantly higher in patients with GHD. Carotid artery intima-media thickness (IMT) values were significantly higher in patients with GHD compared to healthy children (IMT-L 0.53 +/- 0.058 mm vs 0.41 +/- 0.045 mm; IMT-R 0.54 +/- 0.048 vs 0.42 +/- 0.42 mm, respectively).

CONCLUSIONS

No significant differences in parameters of cardiac systolic function and left ventricular mass were found between patients with GHD and healthy children. However, significantly higher Isovolumetric relaxation time (IVRT) values in the group of patients may suggest impaired diastolic function. Significantly elevated IMT values in the common carotid artery were observed in patients with GHD in comparison with healthy children, which may prove the onset of atheromatosis.

Authors+Show Affiliations

Szczepańiska Kostro J
2nd Department of Children's Diseases, Medical University of Białystok, Poland. jkostro@hoga.pl
Tołwińska J
No affiliation info available
Urban M
No affiliation info available
Gardziejczyk M
No affiliation info available
Głowińska B
No affiliation info available

MeSH

AdolescentCardiomegalyCardiovascular DiseasesCarotid ArteriesCarotid Artery DiseasesChildDiastoleEchocardiographyFemaleGrowth DisordersHeart Function TestsHomocysteineHuman Growth HormoneHumansLipid MetabolismLipoproteinsMaleOrgan SizeReference ValuesRisk FactorsTunica Intima

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

15526719

Citation

Szczepańiska Kostro, Jolanta, et al. "Cardiac Mass and Function, Carotid Artery Intima Media Thickness, Homocysteine and Lipoprotein Levels in Children and Adolescents With Growth Hormone Deficiency." Journal of Pediatric Endocrinology & Metabolism : JPEM, vol. 17, no. 10, 2004, pp. 1405-13.
Szczepańiska Kostro J, Tołwińska J, Urban M, et al. Cardiac mass and function, carotid artery intima media thickness, homocysteine and lipoprotein levels in children and adolescents with growth hormone deficiency. J Pediatr Endocrinol Metab. 2004;17(10):1405-13.
Szczepańiska Kostro, J., Tołwińska, J., Urban, M., Gardziejczyk, M., & Głowińska, B. (2004). Cardiac mass and function, carotid artery intima media thickness, homocysteine and lipoprotein levels in children and adolescents with growth hormone deficiency. Journal of Pediatric Endocrinology & Metabolism : JPEM, 17(10), 1405-13.
Szczepańiska Kostro J, et al. Cardiac Mass and Function, Carotid Artery Intima Media Thickness, Homocysteine and Lipoprotein Levels in Children and Adolescents With Growth Hormone Deficiency. J Pediatr Endocrinol Metab. 2004;17(10):1405-13. PubMed PMID: 15526719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiac mass and function, carotid artery intima media thickness, homocysteine and lipoprotein levels in children and adolescents with growth hormone deficiency. AU - Szczepańiska Kostro,Jolanta, AU - Tołwińska,Joanna, AU - Urban,Mirosława, AU - Gardziejczyk,Maria, AU - Głowińska,Barbara, PY - 2004/11/6/pubmed PY - 2005/6/14/medline PY - 2004/11/6/entrez SP - 1405 EP - 13 JF - Journal of pediatric endocrinology & metabolism : JPEM JO - J Pediatr Endocrinol Metab VL - 17 IS - 10 N2 - INTRODUCTION: Early atheromatic changes have been found in the carotid and the femoral arteries of young adults with growth hormone (GH) deficiency (GHD). It has been shown that adults with GHD have increased cardiovascular risk factors. The aim of this study was to compare atherosclerotic risk factors in children with GHD and a normal population. PATIENTS AND METHODS: Twenty-five patients (10 girls, 15 boys) with GHD qualified for GH replacement treatment were included in the study. The control group consisted of 22 healthy children (11 girls, 11 boys) with no family history of atherosclerosis and cardiovascular disease. Cardiac mass and function was evaluated by one-dimensional, two-dimensional echocardiography and the Doppler method. Common carotid intima-media thickness was measured with a linear probe (7.5 MHz). Lipid metabolism parameters (total cholesterol, HDL- and LDL-cholesterol, triglycerides), lipoprotein A (Lp(a)) and homocysteine levels were measured. RESULTS: Cardiac dimensions and systolic parameters were within normal values in both groups. The mean index of left ventricular mass (68.37 +/- 18.64 g/m2) in patients with GHD did not differ significantly compared to controls (68.48 +/- 15.56 g/m2). No significant differences between the study and control group were observed when comparing systolic and ejection fraction values. Significantly higher mean values of IVRT parameter were found (70.8 +/- 14.2 ms vs 64.09 +/- 8.54% ms; p < 0.05). Other parameters characterizing systolic function were not significantly different. The mean concentration of total (178.28 +/- 31.1 mg/dl) and LDL-cholesterol (106 +/- 28.68 mg/dl) was significantly higher in patients with GHD than in controls (157.59 +/- 22.39 mg/dl, 84.54 +/- 22.01 mg/dl; p <0.05). Lp(a) (40.34 +/- 12.45 mg/dl vs 11.02 +/- 4.82 mg/dl; p <0.05) and apolipoprotein B (ApoB) (71.12 +/- 18 mg/dl vs 56.72 +/- 11.46 mg/dl; p < 0.05) were significantly higher in patients with GHD. Carotid artery intima-media thickness (IMT) values were significantly higher in patients with GHD compared to healthy children (IMT-L 0.53 +/- 0.058 mm vs 0.41 +/- 0.045 mm; IMT-R 0.54 +/- 0.048 vs 0.42 +/- 0.42 mm, respectively). CONCLUSIONS: No significant differences in parameters of cardiac systolic function and left ventricular mass were found between patients with GHD and healthy children. However, significantly higher Isovolumetric relaxation time (IVRT) values in the group of patients may suggest impaired diastolic function. Significantly elevated IMT values in the common carotid artery were observed in patients with GHD in comparison with healthy children, which may prove the onset of atheromatosis. SN - 0334-018X UR - https://www.unboundmedicine.com/medline/citation/15526719/Cardiac_mass_and_function_carotid_artery_intima_media_thickness_homocysteine_and_lipoprotein_levels_in_children_and_adolescents_with_growth_hormone_deficiency_ L2 - https://www.diseaseinfosearch.org/result/3193 DB - PRIME DP - Unbound Medicine ER -