Tags

Type your tag names separated by a space and hit enter

An evaluation of clinical and histopathological status in paucibacillary leprosy patients after completion of fixed duration therapy.
Indian J Lepr. 2004 Jan-Mar; 76(1):11-8.IJ

Abstract

The present study was carried out involving 25 patients with paucibacillary leprosy who attended the outpatient department of dermatology of Father Muller's Medical College Hospital during the period January 2001 to March 2002. All the patients were examined clinically and histopathologically at the beginning and at the end of six months of MDT and relevant data recorded. Clinicopathological correlation with histopathological classification before MDT was 72% and 68% at the end of MDT in our study. At the end of treatment 4 (16%) cases were clinically active and 8 (32%) were histopathologlcally active. The study showed that active cases were significantly reduced as a result of MDT, both clinically and histopathologically. The histopathological activity that outlasts MDT may be due to the bacillary fragments that persist; but clinical activity coupled with histopathological activity seen in 2 patients at the end of 6 months of MDT was possibly an indicator of relapse and these patients and similar others need to be followed up for a longer duration. In this study, resolution of granuloma and clinical activity after completion of MDT were assessed.

Authors+Show Affiliations

Department of Dermatology, Venereology & Leprosy, Father Muller Medical College, Kankanady, Mangalore 575 002, Karnataka.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

15527055

Citation

Mathew, D, et al. "An Evaluation of Clinical and Histopathological Status in Paucibacillary Leprosy Patients After Completion of Fixed Duration Therapy." Indian Journal of Leprosy, vol. 76, no. 1, 2004, pp. 11-8.
Mathew D, Kishore BN, Shwethadri GK, et al. An evaluation of clinical and histopathological status in paucibacillary leprosy patients after completion of fixed duration therapy. Indian J Lepr. 2004;76(1):11-8.
Mathew, D., Kishore, B. N., Shwethadri, G. K., Sukumar, ., & Shetty, N. J. (2004). An evaluation of clinical and histopathological status in paucibacillary leprosy patients after completion of fixed duration therapy. Indian Journal of Leprosy, 76(1), 11-8.
Mathew D, et al. An Evaluation of Clinical and Histopathological Status in Paucibacillary Leprosy Patients After Completion of Fixed Duration Therapy. Indian J Lepr. 2004 Jan-Mar;76(1):11-8. PubMed PMID: 15527055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An evaluation of clinical and histopathological status in paucibacillary leprosy patients after completion of fixed duration therapy. AU - Mathew,D, AU - Kishore,B Nanda, AU - Shwethadri,G K, AU - Sukumar,, AU - Shetty,N J, PY - 2004/11/6/pubmed PY - 2005/1/26/medline PY - 2004/11/6/entrez SP - 11 EP - 8 JF - Indian journal of leprosy JO - Indian J Lepr VL - 76 IS - 1 N2 - The present study was carried out involving 25 patients with paucibacillary leprosy who attended the outpatient department of dermatology of Father Muller's Medical College Hospital during the period January 2001 to March 2002. All the patients were examined clinically and histopathologically at the beginning and at the end of six months of MDT and relevant data recorded. Clinicopathological correlation with histopathological classification before MDT was 72% and 68% at the end of MDT in our study. At the end of treatment 4 (16%) cases were clinically active and 8 (32%) were histopathologlcally active. The study showed that active cases were significantly reduced as a result of MDT, both clinically and histopathologically. The histopathological activity that outlasts MDT may be due to the bacillary fragments that persist; but clinical activity coupled with histopathological activity seen in 2 patients at the end of 6 months of MDT was possibly an indicator of relapse and these patients and similar others need to be followed up for a longer duration. In this study, resolution of granuloma and clinical activity after completion of MDT were assessed. SN - 0254-9395 UR - https://www.unboundmedicine.com/medline/citation/15527055/An_evaluation_of_clinical_and_histopathological_status_in_paucibacillary_leprosy_patients_after_completion_of_fixed_duration_therapy_ DB - PRIME DP - Unbound Medicine ER -