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Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system.
Free Radic Biol Med. 2004 Dec 01; 37(11):1683-93.FR

Abstract

Over the past few years there has been an exponential growth in the number of reports describing the effects of nutritional modulation on aging and age-related diseases. Specific attention has been directed toward the beneficial effects afforded by dietary antioxidants, in particular those from fruit and vegetables, in ameliorating age-related deficits in brain performance. The rationale for studying the effects of dietary intervention stems from evidence implicating free radicals in aspects related to the aging process. Age-dependent neuropathology is a cumulative response to alterations induced by reactive oxygen species. Therefore cognitive aging, according to this hypothesis, should be slowed, and possibly even reversed, by appropriately increasing levels of antioxidants or decreasing overproduction of free radicals in the body.

Authors+Show Affiliations

Antioxidant Research Group, Wolfson Centre for Age-Related Diseases, Guy's King's and St. Thomas's School of Biomedical Sciences, King's College, London SE1 9RT, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15528027

Citation

Youdim, Kuresh A., et al. "Flavonoids and the Brain: Interactions at the Blood-brain Barrier and Their Physiological Effects On the Central Nervous System." Free Radical Biology & Medicine, vol. 37, no. 11, 2004, pp. 1683-93.
Youdim KA, Shukitt-Hale B, Joseph JA. Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system. Free Radic Biol Med. 2004;37(11):1683-93.
Youdim, K. A., Shukitt-Hale, B., & Joseph, J. A. (2004). Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system. Free Radical Biology & Medicine, 37(11), 1683-93.
Youdim KA, Shukitt-Hale B, Joseph JA. Flavonoids and the Brain: Interactions at the Blood-brain Barrier and Their Physiological Effects On the Central Nervous System. Free Radic Biol Med. 2004 Dec 1;37(11):1683-93. PubMed PMID: 15528027.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system. AU - Youdim,Kuresh A, AU - Shukitt-Hale,Barbara, AU - Joseph,James A, PY - 2004/01/16/received PY - 2004/07/22/revised PY - 2004/08/05/accepted PY - 2004/11/6/pubmed PY - 2005/4/19/medline PY - 2004/11/6/entrez SP - 1683 EP - 93 JF - Free radical biology & medicine JO - Free Radic Biol Med VL - 37 IS - 11 N2 - Over the past few years there has been an exponential growth in the number of reports describing the effects of nutritional modulation on aging and age-related diseases. Specific attention has been directed toward the beneficial effects afforded by dietary antioxidants, in particular those from fruit and vegetables, in ameliorating age-related deficits in brain performance. The rationale for studying the effects of dietary intervention stems from evidence implicating free radicals in aspects related to the aging process. Age-dependent neuropathology is a cumulative response to alterations induced by reactive oxygen species. Therefore cognitive aging, according to this hypothesis, should be slowed, and possibly even reversed, by appropriately increasing levels of antioxidants or decreasing overproduction of free radicals in the body. SN - 0891-5849 UR - https://www.unboundmedicine.com/medline/citation/15528027/Flavonoids_and_the_brain:_interactions_at_the_blood_brain_barrier_and_their_physiological_effects_on_the_central_nervous_system_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0891-5849(04)00635-5 DB - PRIME DP - Unbound Medicine ER -