Tags

Type your tag names separated by a space and hit enter

Experience with mobile inhaled nitric oxide during transport of neonates and children with respiratory insufficiency to an extracorporeal membrane oxygenation center.
Pediatr Crit Care Med. 2004 Nov; 5(6):542-6.PC

Abstract

OBJECTIVE

To share our experience with the use of inhaled nitric oxide (iNO) during the transport of ventilated neonates and children to an extracorporeal membrane oxygenation (ECMO) center and to discuss the efficacy and safety of iNO use in this situation.

DATA SOURCES

Case note review of 55 consecutive patients transported while receiving iNO to Glenfield Hospital, Leicester, UK, for consideration of ECMO.

STUDY SELECTION

Retrospective case note review.

DATA EXTRACTION

The clinical condition of each patient recorded at arrival of the transport team at the referring hospital, during transport, and at arrival at Glenfield Hospital. Preclinical and postclinical conditions were compared using the paired Student's t-test.

DATA SYNTHESIS

Overall data showed a significant improvement in transcutaneous oximetry measurements (Spo(2): 84.8% preclinical, 90.6% postclinical; p = .006) and Pao(2) (59 torr [7.87 kPa] preclinical, 84 torr [11.23 kPa] postclinical; p = .001) during transport in our patient group. Based on limited safety data, no untoward events or toxic metabolites were observed with iNO therapy during transport.

CONCLUSIONS

iNO does appear to improve oxygenation during transfer of patients for ECMO in our series. Based on limited safety data, iNO appears safe to use in transport.

Authors+Show Affiliations

Westrope C
Heartlink ECMO Centre, Glenfield Hospital, Leicester, UK.
Roberts N
No affiliation info available
Nichani S
No affiliation info available
Hunt C
No affiliation info available
Peek GJ
No affiliation info available
Firmin R
No affiliation info available

MeSH

Administration, InhalationBlood Gas Monitoring, TranscutaneousCritical IllnessExtracorporeal Membrane OxygenationHumansInfantInfant, NewbornNitric OxideRespiration, ArtificialRespiratory InsufficiencyRetrospective StudiesTransportation of Patients

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15530190

Citation

Westrope, Claire, et al. "Experience With Mobile Inhaled Nitric Oxide During Transport of Neonates and Children With Respiratory Insufficiency to an Extracorporeal Membrane Oxygenation Center." Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, vol. 5, no. 6, 2004, pp. 542-6.
Westrope C, Roberts N, Nichani S, et al. Experience with mobile inhaled nitric oxide during transport of neonates and children with respiratory insufficiency to an extracorporeal membrane oxygenation center. Pediatr Crit Care Med. 2004;5(6):542-6.
Westrope, C., Roberts, N., Nichani, S., Hunt, C., Peek, G. J., & Firmin, R. (2004). Experience with mobile inhaled nitric oxide during transport of neonates and children with respiratory insufficiency to an extracorporeal membrane oxygenation center. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 5(6), 542-6.
Westrope C, et al. Experience With Mobile Inhaled Nitric Oxide During Transport of Neonates and Children With Respiratory Insufficiency to an Extracorporeal Membrane Oxygenation Center. Pediatr Crit Care Med. 2004;5(6):542-6. PubMed PMID: 15530190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experience with mobile inhaled nitric oxide during transport of neonates and children with respiratory insufficiency to an extracorporeal membrane oxygenation center. AU - Westrope,Claire, AU - Roberts,Neil, AU - Nichani,Sanjiv, AU - Hunt,Carmel, AU - Peek,Giles J, AU - Firmin,Richard, PY - 2004/11/9/pubmed PY - 2005/5/12/medline PY - 2004/11/9/entrez SP - 542 EP - 6 JF - Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies JO - Pediatr Crit Care Med VL - 5 IS - 6 N2 - OBJECTIVE: To share our experience with the use of inhaled nitric oxide (iNO) during the transport of ventilated neonates and children to an extracorporeal membrane oxygenation (ECMO) center and to discuss the efficacy and safety of iNO use in this situation. DATA SOURCES: Case note review of 55 consecutive patients transported while receiving iNO to Glenfield Hospital, Leicester, UK, for consideration of ECMO. STUDY SELECTION: Retrospective case note review. DATA EXTRACTION: The clinical condition of each patient recorded at arrival of the transport team at the referring hospital, during transport, and at arrival at Glenfield Hospital. Preclinical and postclinical conditions were compared using the paired Student's t-test. DATA SYNTHESIS: Overall data showed a significant improvement in transcutaneous oximetry measurements (Spo(2): 84.8% preclinical, 90.6% postclinical; p = .006) and Pao(2) (59 torr [7.87 kPa] preclinical, 84 torr [11.23 kPa] postclinical; p = .001) during transport in our patient group. Based on limited safety data, no untoward events or toxic metabolites were observed with iNO therapy during transport. CONCLUSIONS: iNO does appear to improve oxygenation during transfer of patients for ECMO in our series. Based on limited safety data, iNO appears safe to use in transport. SN - 1529-7535 UR - https://www.unboundmedicine.com/medline/citation/15530190/Experience_with_mobile_inhaled_nitric_oxide_during_transport_of_neonates_and_children_with_respiratory_insufficiency_to_an_extracorporeal_membrane_oxygenation_center_ DB - PRIME DP - Unbound Medicine ER -