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Contribution of postprandial lipemia to the dietary fat-mediated changes in endogenous lipoprotein-cholesterol concentrations in humans.
Am J Clin Nutr 2004; 80(5):1145-58AJ

Abstract

BACKGROUND

Dietary fats alter LDL and HDL cholesterol while serving as precursors of postprandial triacylglycerol-rich lipoproteins (TRLs).

OBJECTIVE

We hypothesized that the saturated fatty acid (SFA)-mediated increase and the polyunsaturated fatty acid (PUFA)-mediated decrease in endogenous lipoprotein cholesterol are promoted by postprandial TRLs.

DESIGN

We performed a 16-d crossover diet study to examine the effect of PUFA-rich [ratio of PUFAs to SFAs (P:S) = 2.0] and SFA-rich (P:S = 0.25) diets on fasting and postprandial plasma lipid and lipoprotein-cholesterol concentrations in 16 normolipidemic subjects.

RESULTS

Fasting plasma cholesterol decreased significantly after a PUFA-rich diet because of a decrease in LDL (-12.3%; P < 0.05) and HDL (-3.8%; NS), but did not change after an SFA-rich diet. The appearance of postprandial TRLs in plasma at 4 h was linked to a significant lowering of both LDL (-7.4%) and HDL (-4.8%) after a PUFA-rich diet; no such effect was observed after the SFA-rich diet. At 7 h, LDL and HDL cholesterol returned to near fasting concentrations without postprandial TRL accumulation after a PUFA-rich diet but with a significant postprandial TRL accumulation after an SFA-rich diet. Thus, the in vivo postprandial clearance of cholesterol in LDL+HDL was greater after a PUFA-rich diet than after an SFA-rich diet. The appearance of postprandial TRLs in plasma increased the cholesteryl ester transfer protein-mediated transfer of cholesteryl ester from LDL+HDL to TRLs in vitro without a significant influence from dietary fat.

CONCLUSION

Dietary fat-mediated alterations in the rate of hepatic removal of postprandial TRLs, which carry cholesterol accepted from LDL+HDL via cholesteryl ester transfer protein in vivo, may contribute to the dietary fat-mediated change in endogenous lipoprotein cholesterol.

Authors+Show Affiliations

Atherosclerosis Research Unit, Medical School, University of Alabama at Birmingham, and the Moore Heart Research Foundation, University of Illinois, Champaign, IL, USA. bhchung@uab.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15531660

Citation

Chung, Byung-Hong, et al. "Contribution of Postprandial Lipemia to the Dietary Fat-mediated Changes in Endogenous Lipoprotein-cholesterol Concentrations in Humans." The American Journal of Clinical Nutrition, vol. 80, no. 5, 2004, pp. 1145-58.
Chung BH, Cho BH, Liang P, et al. Contribution of postprandial lipemia to the dietary fat-mediated changes in endogenous lipoprotein-cholesterol concentrations in humans. Am J Clin Nutr. 2004;80(5):1145-58.
Chung, B. H., Cho, B. H., Liang, P., Doran, S., Osterlund, L., Oster, R. A., ... Franklin, F. (2004). Contribution of postprandial lipemia to the dietary fat-mediated changes in endogenous lipoprotein-cholesterol concentrations in humans. The American Journal of Clinical Nutrition, 80(5), pp. 1145-58.
Chung BH, et al. Contribution of Postprandial Lipemia to the Dietary Fat-mediated Changes in Endogenous Lipoprotein-cholesterol Concentrations in Humans. Am J Clin Nutr. 2004;80(5):1145-58. PubMed PMID: 15531660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contribution of postprandial lipemia to the dietary fat-mediated changes in endogenous lipoprotein-cholesterol concentrations in humans. AU - Chung,Byung-Hong, AU - Cho,B H Simon, AU - Liang,Ping, AU - Doran,Steve, AU - Osterlund,Laura, AU - Oster,Robert A, AU - Darnell,Betty, AU - Franklin,Frank, PY - 2004/11/9/pubmed PY - 2004/12/16/medline PY - 2004/11/9/entrez SP - 1145 EP - 58 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 80 IS - 5 N2 - BACKGROUND: Dietary fats alter LDL and HDL cholesterol while serving as precursors of postprandial triacylglycerol-rich lipoproteins (TRLs). OBJECTIVE: We hypothesized that the saturated fatty acid (SFA)-mediated increase and the polyunsaturated fatty acid (PUFA)-mediated decrease in endogenous lipoprotein cholesterol are promoted by postprandial TRLs. DESIGN: We performed a 16-d crossover diet study to examine the effect of PUFA-rich [ratio of PUFAs to SFAs (P:S) = 2.0] and SFA-rich (P:S = 0.25) diets on fasting and postprandial plasma lipid and lipoprotein-cholesterol concentrations in 16 normolipidemic subjects. RESULTS: Fasting plasma cholesterol decreased significantly after a PUFA-rich diet because of a decrease in LDL (-12.3%; P < 0.05) and HDL (-3.8%; NS), but did not change after an SFA-rich diet. The appearance of postprandial TRLs in plasma at 4 h was linked to a significant lowering of both LDL (-7.4%) and HDL (-4.8%) after a PUFA-rich diet; no such effect was observed after the SFA-rich diet. At 7 h, LDL and HDL cholesterol returned to near fasting concentrations without postprandial TRL accumulation after a PUFA-rich diet but with a significant postprandial TRL accumulation after an SFA-rich diet. Thus, the in vivo postprandial clearance of cholesterol in LDL+HDL was greater after a PUFA-rich diet than after an SFA-rich diet. The appearance of postprandial TRLs in plasma increased the cholesteryl ester transfer protein-mediated transfer of cholesteryl ester from LDL+HDL to TRLs in vitro without a significant influence from dietary fat. CONCLUSION: Dietary fat-mediated alterations in the rate of hepatic removal of postprandial TRLs, which carry cholesterol accepted from LDL+HDL via cholesteryl ester transfer protein in vivo, may contribute to the dietary fat-mediated change in endogenous lipoprotein cholesterol. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/15531660/Contribution_of_postprandial_lipemia_to_the_dietary_fat_mediated_changes_in_endogenous_lipoprotein_cholesterol_concentrations_in_humans_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/80.5.1145 DB - PRIME DP - Unbound Medicine ER -