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Breastfeeding and risk of inflammatory bowel disease: a systematic review with meta-analysis.

Abstract

BACKGROUND

It has long been believed that breastfeeding provides protection against ulcerative colitis and Crohn disease. Studies designated to test this hypothesis were conducted without reaching conclusive results.

OBJECTIVE

The aim of this meta-analysis was to examine the role of breastfeeding in preventing inflammatory bowel disease and to summarize the evidence gathered about this subject.

DESIGN

A meta-analysis was performed on 17 relevant articles that were found by using MEDLINE, EMBASE, the Internet, and articles' references. The publications were fully reviewed and divided, on the basis of their quality, into 3 groups.

RESULTS

Studies showed heterogeneous results. The pooled odds ratios of all the 17 reviewed studies, calculated according to the random-effects model, were 0.67 (95% CI: 0.52, 0.86) for Crohn disease and 0.77 (0.61, 0.96) for ulcerative colitis. However, only 4 studies for Crohn disease and 4 for ulcerative colitis were eventually included in the highest quality group. In this group, the pooled odds ratio was 0.45 (0.26, 0.79) for Crohn disease and 0.56 (0.38, 0.81) for ulcerative colitis.

CONCLUSIONS

The results of this meta-analysis support the hypothesis that breastfeeding is associated with lower risks of Crohn disease and ulcerative colitis. However, because only a few studies were graded to be of high quality, we suggest that further research, conducted with good methodology and large sample sizes, should be carried out to strengthen the validity of these observations.

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  • Authors+Show Affiliations

    ,

    Koret School of Veterinary Medicine, the Hebrew University of Jerusalem, Rehovot, Israel. klement@agri.huij.ac.il

    , , ,

    Source

    MeSH

    Breast Feeding
    Case-Control Studies
    Crohn Disease
    Female
    Humans
    Inflammatory Bowel Diseases
    Risk

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    15531685

    Citation

    Klement, Eyal, et al. "Breastfeeding and Risk of Inflammatory Bowel Disease: a Systematic Review With Meta-analysis." The American Journal of Clinical Nutrition, vol. 80, no. 5, 2004, pp. 1342-52.
    Klement E, Cohen RV, Boxman J, et al. Breastfeeding and risk of inflammatory bowel disease: a systematic review with meta-analysis. Am J Clin Nutr. 2004;80(5):1342-52.
    Klement, E., Cohen, R. V., Boxman, J., Joseph, A., & Reif, S. (2004). Breastfeeding and risk of inflammatory bowel disease: a systematic review with meta-analysis. The American Journal of Clinical Nutrition, 80(5), pp. 1342-52.
    Klement E, et al. Breastfeeding and Risk of Inflammatory Bowel Disease: a Systematic Review With Meta-analysis. Am J Clin Nutr. 2004;80(5):1342-52. PubMed PMID: 15531685.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Breastfeeding and risk of inflammatory bowel disease: a systematic review with meta-analysis. AU - Klement,Eyal, AU - Cohen,Regev V, AU - Boxman,Jonathan, AU - Joseph,Aviva, AU - Reif,Shimon, PY - 2004/11/9/pubmed PY - 2004/12/16/medline PY - 2004/11/9/entrez SP - 1342 EP - 52 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 80 IS - 5 N2 - BACKGROUND: It has long been believed that breastfeeding provides protection against ulcerative colitis and Crohn disease. Studies designated to test this hypothesis were conducted without reaching conclusive results. OBJECTIVE: The aim of this meta-analysis was to examine the role of breastfeeding in preventing inflammatory bowel disease and to summarize the evidence gathered about this subject. DESIGN: A meta-analysis was performed on 17 relevant articles that were found by using MEDLINE, EMBASE, the Internet, and articles' references. The publications were fully reviewed and divided, on the basis of their quality, into 3 groups. RESULTS: Studies showed heterogeneous results. The pooled odds ratios of all the 17 reviewed studies, calculated according to the random-effects model, were 0.67 (95% CI: 0.52, 0.86) for Crohn disease and 0.77 (0.61, 0.96) for ulcerative colitis. However, only 4 studies for Crohn disease and 4 for ulcerative colitis were eventually included in the highest quality group. In this group, the pooled odds ratio was 0.45 (0.26, 0.79) for Crohn disease and 0.56 (0.38, 0.81) for ulcerative colitis. CONCLUSIONS: The results of this meta-analysis support the hypothesis that breastfeeding is associated with lower risks of Crohn disease and ulcerative colitis. However, because only a few studies were graded to be of high quality, we suggest that further research, conducted with good methodology and large sample sizes, should be carried out to strengthen the validity of these observations. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/15531685/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/80.5.1342 DB - PRIME DP - Unbound Medicine ER -