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Milk and lactose intakes and ovarian cancer risk in the Swedish Mammography Cohort.

Abstract

BACKGROUND

High intakes of dairy products and of the milk sugar lactose have been hypothesized to increase ovarian cancer risk, but prospective data are scarce.

OBJECTIVE

We examined the association between intakes of dairy products and lactose and the risk of total epithelial ovarian cancer and its subtypes.

DESIGN

This was a prospective population-based cohort study of 61 084 women aged 38-76 y who were enrolled in the Swedish Mammography Cohort. Diet was assessed in 1987-1990 with the use of a self-administered food-frequency questionnaire. During an average follow-up of 13.5 y, 266 women were diagnosed with invasive epithelial ovarian cancer; 125 of those women had serous ovarian cancer.

RESULTS

After adjustment for potential confounders, women who consumed >/=4 servings of total dairy products/d had a risk of serous ovarian cancer (rate ratio: 2.0; 95% CI: 1.1, 3.7; P for trend = 0.06) twice that of women who consumed <2 servings/d. No significant association was found for other subtypes of ovarian cancer. Milk was the dairy product with the strongest positive association with serous ovarian cancer (rate ratio comparing consuming >/=2 glasses milk/d with consuming milk never or seldom: 2.0; 95% CI: 1.1, 3.7; P for trend = 0.04). We observed a positive association between lactose intake and serous ovarian cancer risk (P for trend = 0.006).

CONCLUSIONS

Our data indicate that high intakes of lactose and dairy products, particularly milk, are associated with an increased risk of serous ovarian cancer but not of other subtypes of ovarian cancer. Future studies should consider ovarian cancer subtypes separately.

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  • Authors+Show Affiliations

    ,

    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. susanna.larsson@imm.ki.se

    ,

    Source

    MeSH

    Adult
    Aged
    Animals
    Body Mass Index
    Cohort Studies
    Diet
    Female
    Humans
    Incidence
    Lactose
    Middle Aged
    Milk
    Ovarian Neoplasms
    Risk
    Surveys and Questionnaires
    Sweden

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15531686

    Citation

    Larsson, Susanna C., et al. "Milk and Lactose Intakes and Ovarian Cancer Risk in the Swedish Mammography Cohort." The American Journal of Clinical Nutrition, vol. 80, no. 5, 2004, pp. 1353-7.
    Larsson SC, Bergkvist L, Wolk A. Milk and lactose intakes and ovarian cancer risk in the Swedish Mammography Cohort. Am J Clin Nutr. 2004;80(5):1353-7.
    Larsson, S. C., Bergkvist, L., & Wolk, A. (2004). Milk and lactose intakes and ovarian cancer risk in the Swedish Mammography Cohort. The American Journal of Clinical Nutrition, 80(5), pp. 1353-7.
    Larsson SC, Bergkvist L, Wolk A. Milk and Lactose Intakes and Ovarian Cancer Risk in the Swedish Mammography Cohort. Am J Clin Nutr. 2004;80(5):1353-7. PubMed PMID: 15531686.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Milk and lactose intakes and ovarian cancer risk in the Swedish Mammography Cohort. AU - Larsson,Susanna C, AU - Bergkvist,Leif, AU - Wolk,Alicja, PY - 2004/11/9/pubmed PY - 2004/12/16/medline PY - 2004/11/9/entrez SP - 1353 EP - 7 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 80 IS - 5 N2 - BACKGROUND: High intakes of dairy products and of the milk sugar lactose have been hypothesized to increase ovarian cancer risk, but prospective data are scarce. OBJECTIVE: We examined the association between intakes of dairy products and lactose and the risk of total epithelial ovarian cancer and its subtypes. DESIGN: This was a prospective population-based cohort study of 61 084 women aged 38-76 y who were enrolled in the Swedish Mammography Cohort. Diet was assessed in 1987-1990 with the use of a self-administered food-frequency questionnaire. During an average follow-up of 13.5 y, 266 women were diagnosed with invasive epithelial ovarian cancer; 125 of those women had serous ovarian cancer. RESULTS: After adjustment for potential confounders, women who consumed >/=4 servings of total dairy products/d had a risk of serous ovarian cancer (rate ratio: 2.0; 95% CI: 1.1, 3.7; P for trend = 0.06) twice that of women who consumed <2 servings/d. No significant association was found for other subtypes of ovarian cancer. Milk was the dairy product with the strongest positive association with serous ovarian cancer (rate ratio comparing consuming >/=2 glasses milk/d with consuming milk never or seldom: 2.0; 95% CI: 1.1, 3.7; P for trend = 0.04). We observed a positive association between lactose intake and serous ovarian cancer risk (P for trend = 0.006). CONCLUSIONS: Our data indicate that high intakes of lactose and dairy products, particularly milk, are associated with an increased risk of serous ovarian cancer but not of other subtypes of ovarian cancer. Future studies should consider ovarian cancer subtypes separately. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/15531686/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/80.5.1353 DB - PRIME DP - Unbound Medicine ER -