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Effects of soy isoflavones on menopausal neurovegetative symptoms.
Minerva Ginecol. 2004 Oct; 56(5):407-12.MG

Abstract

AIM

Dietary soy supplementation may reduce the incidence of hot flushes in postmenopausal women due to the presence of phytoestrogens in soy foods. The aim of this study was to assess the effects of a 3-month administration of different doses of either oral or transdermal soy isoflavones on climacteric complaints in postmenopausal women.

METHODS

Sixty postmenopausal women were assigned randomly to one of the following groups: groups A and B received 50 mg/day or 75 mg/day of oral isoflavones respectively, while groups C and D received 6 mg/day or 12 mg/day of transdermal isoflavones. A control group (group E) was composed of 15 patients that did not receive any treatment. Hot flushes, Kupper-man index and vaginal dryness at baseline and then after 5, 9 and 13 weeks were evaluated.

RESULTS

The isoflavone treatment led to a progressive significant (p<0.01) reduction of the number of hot flushes in the groups A, B and D with a dose-related effect in group D. At week 13, the Kupperman index and hot flush score decreased significantly in all the treated groups, while vaginal dryness score was reduced only in group B.

CONCLUSION

Our findings suggest that both oral and transdermal soy isoflavones are effective to attenuate slight to moderate menopausal neurovegetative symptoms with a dose-related effect.

Authors+Show Affiliations

Department of Gynecology and Obstetrics Outpatient, Menopausal Clinic, Second University of Naples, Naples, Italy. nicola.colacurci@unina2.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15531858

Citation

Colacurci, N, et al. "Effects of Soy Isoflavones On Menopausal Neurovegetative Symptoms." Minerva Ginecologica, vol. 56, no. 5, 2004, pp. 407-12.
Colacurci N, Zarcone R, Borrelli A, et al. Effects of soy isoflavones on menopausal neurovegetative symptoms. Minerva Ginecol. 2004;56(5):407-12.
Colacurci, N., Zarcone, R., Borrelli, A., De Franciscis, P., Fortunato, N., Cirillo, M., & Fornaro, F. (2004). Effects of soy isoflavones on menopausal neurovegetative symptoms. Minerva Ginecologica, 56(5), 407-12.
Colacurci N, et al. Effects of Soy Isoflavones On Menopausal Neurovegetative Symptoms. Minerva Ginecol. 2004;56(5):407-12. PubMed PMID: 15531858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of soy isoflavones on menopausal neurovegetative symptoms. AU - Colacurci,N, AU - Zarcone,R, AU - Borrelli,A, AU - De Franciscis,P, AU - Fortunato,N, AU - Cirillo,M, AU - Fornaro,F, PY - 2004/11/9/pubmed PY - 2005/3/18/medline PY - 2004/11/9/entrez SP - 407 EP - 12 JF - Minerva ginecologica JO - Minerva Ginecol VL - 56 IS - 5 N2 - AIM: Dietary soy supplementation may reduce the incidence of hot flushes in postmenopausal women due to the presence of phytoestrogens in soy foods. The aim of this study was to assess the effects of a 3-month administration of different doses of either oral or transdermal soy isoflavones on climacteric complaints in postmenopausal women. METHODS: Sixty postmenopausal women were assigned randomly to one of the following groups: groups A and B received 50 mg/day or 75 mg/day of oral isoflavones respectively, while groups C and D received 6 mg/day or 12 mg/day of transdermal isoflavones. A control group (group E) was composed of 15 patients that did not receive any treatment. Hot flushes, Kupper-man index and vaginal dryness at baseline and then after 5, 9 and 13 weeks were evaluated. RESULTS: The isoflavone treatment led to a progressive significant (p<0.01) reduction of the number of hot flushes in the groups A, B and D with a dose-related effect in group D. At week 13, the Kupperman index and hot flush score decreased significantly in all the treated groups, while vaginal dryness score was reduced only in group B. CONCLUSION: Our findings suggest that both oral and transdermal soy isoflavones are effective to attenuate slight to moderate menopausal neurovegetative symptoms with a dose-related effect. SN - 0026-4784 UR - https://www.unboundmedicine.com/medline/citation/15531858/Effects_of_soy_isoflavones_on_menopausal_neurovegetative_symptoms_ L2 - https://medlineplus.gov/menopause.html DB - PRIME DP - Unbound Medicine ER -