Tags

Type your tag names separated by a space and hit enter

Clinical application of sperm-oocyte interaction tests in in vitro fertilization--embryo transfer and intracytoplasmic sperm injection programs.
Fertil Steril 2004; 82(5):1251-63FS

Abstract

OBJECTIVE

To review the clinical value of sperm-oocyte interaction tests for the diagnosis and management of infertility by standard IVF or intracytoplasmic sperm injection (ICSI).

DESIGN

Review of recent publications on relationships among sperm-oocyte interaction tests, sperm characteristics, and results of IVF and determination of frequency of defective sperm-oocyte interaction in infertile men.

MAIN OUTCOME MEASURE(S)

Fertilization rates with IVF, sperm characteristics, sperm-zona pellucida (ZP) binding, ZP-induced acrosome reaction (AR), and sperm-ZP penetration.

RESULT(S)

Sperm defects associated with low sperm-ZP binding or impaired ZP-induced AR and sperm-ZP penetration are the major causes of failure of fertilization when all or most oocytes from a couple do not fertilize in standard IVF. There is a high frequency of defective sperm-ZP interaction in men with oligozoospermia (<20 x 10(6)/mL) and severe teratozoospermia (strict normal sperm morphology < or =5%). Sperm morphology correlates with sperm-ZP binding, and sperm concentration correlates with ZP-induced AR in infertile men with sperm concentrations >20 x 10(6)/mL. Defective ZP-induced AR may cause infertility in up to 25% men with idiopathic infertility. These patients require ICSI despite the normal standard semen analyses.

CONCLUSION(S)

Sperm-oocyte interaction tests are useful for diagnosis of subtle sperm defects that cause infertility in men without severe abnormalities of semen analysis. Pre-IVF diagnosis of these sperm defects will assist in the clinical assignment of patients to treatment with either standard IVF or ICSI.

Authors+Show Affiliations

Department of Obstetrics and Gynecology and Reproductive Services, The Royal Women's Hospital, University of Melbourne, Melbourne, Victoria, Australia. dyl@unimelb.edu.auNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15533339

Citation

Liu, De Yi, et al. "Clinical Application of Sperm-oocyte Interaction Tests in in Vitro Fertilization--embryo Transfer and Intracytoplasmic Sperm Injection Programs." Fertility and Sterility, vol. 82, no. 5, 2004, pp. 1251-63.
Liu DY, Garrett C, Baker HW. Clinical application of sperm-oocyte interaction tests in in vitro fertilization--embryo transfer and intracytoplasmic sperm injection programs. Fertil Steril. 2004;82(5):1251-63.
Liu, D. Y., Garrett, C., & Baker, H. W. (2004). Clinical application of sperm-oocyte interaction tests in in vitro fertilization--embryo transfer and intracytoplasmic sperm injection programs. Fertility and Sterility, 82(5), pp. 1251-63.
Liu DY, Garrett C, Baker HW. Clinical Application of Sperm-oocyte Interaction Tests in in Vitro Fertilization--embryo Transfer and Intracytoplasmic Sperm Injection Programs. Fertil Steril. 2004;82(5):1251-63. PubMed PMID: 15533339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical application of sperm-oocyte interaction tests in in vitro fertilization--embryo transfer and intracytoplasmic sperm injection programs. AU - Liu,De Yi, AU - Garrett,Claire, AU - Baker,H W Gordon, PY - 2003/09/12/received PY - 2003/10/20/revised PY - 2003/10/20/accepted PY - 2004/11/10/pubmed PY - 2004/12/29/medline PY - 2004/11/10/entrez SP - 1251 EP - 63 JF - Fertility and sterility JO - Fertil. Steril. VL - 82 IS - 5 N2 - OBJECTIVE: To review the clinical value of sperm-oocyte interaction tests for the diagnosis and management of infertility by standard IVF or intracytoplasmic sperm injection (ICSI). DESIGN: Review of recent publications on relationships among sperm-oocyte interaction tests, sperm characteristics, and results of IVF and determination of frequency of defective sperm-oocyte interaction in infertile men. MAIN OUTCOME MEASURE(S): Fertilization rates with IVF, sperm characteristics, sperm-zona pellucida (ZP) binding, ZP-induced acrosome reaction (AR), and sperm-ZP penetration. RESULT(S): Sperm defects associated with low sperm-ZP binding or impaired ZP-induced AR and sperm-ZP penetration are the major causes of failure of fertilization when all or most oocytes from a couple do not fertilize in standard IVF. There is a high frequency of defective sperm-ZP interaction in men with oligozoospermia (<20 x 10(6)/mL) and severe teratozoospermia (strict normal sperm morphology < or =5%). Sperm morphology correlates with sperm-ZP binding, and sperm concentration correlates with ZP-induced AR in infertile men with sperm concentrations >20 x 10(6)/mL. Defective ZP-induced AR may cause infertility in up to 25% men with idiopathic infertility. These patients require ICSI despite the normal standard semen analyses. CONCLUSION(S): Sperm-oocyte interaction tests are useful for diagnosis of subtle sperm defects that cause infertility in men without severe abnormalities of semen analysis. Pre-IVF diagnosis of these sperm defects will assist in the clinical assignment of patients to treatment with either standard IVF or ICSI. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/15533339/Clinical_application_of_sperm_oocyte_interaction_tests_in_in_vitro_fertilization__embryo_transfer_and_intracytoplasmic_sperm_injection_programs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(04)02252-6 DB - PRIME DP - Unbound Medicine ER -