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Serum oxidized low-density lipoprotein levels and risk of colorectal cancer: a case-control study nested in the Japan Collaborative Cohort Study.

Abstract

Oxidative stress plays an important role in carcinogenesis, but few epidemiologic studies have examined associations with risk of colorectal cancer. Relationships between serum levels of oxidized low-density lipoprotein (oxLDL) and oxLDL antibody (oLAB) and colorectal cancer risk were investigated in a case-control study nested in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Serum samples and lifestyle information were collected at baseline from 39,242 men and women between 1988 and 1990. Of these, 161 incidents and deaths from colorectal cancer were identified through 1999, and 395 controls were matched for gender, age, and study area. Measurements were taken of serum oxLDL levels in 119 cases and 316 controls and serum oLAB levels in 153 cases and 376 controls. Odds ratios (95% confidence intervals) across quartiles, adjusted for confounding factors, were 1.55 (0.70-3.46), 1.90 (0.84-4.28), and 3.65 (1.50-8.92) for oxLDL (P(trend) = 0.004) and 0.98 (0.54-1.80), 0.75 (0.39-1.48), and 1.68 (0.90-3.13) for oLAB (P(trend) = 0.140). Further adjustment for serum total cholesterol and alpha-tocopherol did not materially change these associations. Odds ratio (95% confidence interval) of the highest quartile of serum oxLDL compared with the lowest quartile was 3.40 (1.09-10.58; P(trend) = 0.045). Analyses restricted to colon cancer cases and corresponding controls yielded similar relationships between serum oxLDL and oLAB levels and risk. In conclusion, higher levels of serum oxLDL may increase risk of colorectal cancer.

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  • Authors+Show Affiliations

    ,

    Department of Public Health, Fujita Health University School of Health Sciences, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan. ksuzuki@fujita-hu.ac.jp

    , , , , , , , , , , , , ,

    Source

    MeSH

    Adult
    Aged
    Alcohol Drinking
    Case-Control Studies
    Colorectal Neoplasms
    Confidence Intervals
    Diet
    Female
    Humans
    Japan
    Life Style
    Lipoproteins, LDL
    Male
    Middle Aged
    Oxidative Stress
    Risk Factors
    Smoking

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15533907

    Citation

    Suzuki, Koji, et al. "Serum Oxidized Low-density Lipoprotein Levels and Risk of Colorectal Cancer: a Case-control Study Nested in the Japan Collaborative Cohort Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 13, no. 11 Pt 1, 2004, pp. 1781-7.
    Suzuki K, Ito Y, Wakai K, et al. Serum oxidized low-density lipoprotein levels and risk of colorectal cancer: a case-control study nested in the Japan Collaborative Cohort Study. Cancer Epidemiol Biomarkers Prev. 2004;13(11 Pt 1):1781-7.
    Suzuki, K., Ito, Y., Wakai, K., Kawado, M., Hashimoto, S., Toyoshima, H., ... Tamakoshi, A. (2004). Serum oxidized low-density lipoprotein levels and risk of colorectal cancer: a case-control study nested in the Japan Collaborative Cohort Study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 13(11 Pt 1), pp. 1781-7.
    Suzuki K, et al. Serum Oxidized Low-density Lipoprotein Levels and Risk of Colorectal Cancer: a Case-control Study Nested in the Japan Collaborative Cohort Study. Cancer Epidemiol Biomarkers Prev. 2004;13(11 Pt 1):1781-7. PubMed PMID: 15533907.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Serum oxidized low-density lipoprotein levels and risk of colorectal cancer: a case-control study nested in the Japan Collaborative Cohort Study. AU - Suzuki,Koji, AU - Ito,Yoshinori, AU - Wakai,Kenji, AU - Kawado,Miyuki, AU - Hashimoto,Shuji, AU - Toyoshima,Hideaki, AU - Kojima,Masayo, AU - Tokudome,Shinkan, AU - Hayakawa,Norihiko, AU - Watanabe,Yoshiyuki, AU - Tamakoshi,Koji, AU - Suzuki,Sadao, AU - Ozasa,Kotaro, AU - Tamakoshi,Akiko, AU - ,, PY - 2004/11/10/pubmed PY - 2005/2/3/medline PY - 2004/11/10/entrez SP - 1781 EP - 7 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 13 IS - 11 Pt 1 N2 - Oxidative stress plays an important role in carcinogenesis, but few epidemiologic studies have examined associations with risk of colorectal cancer. Relationships between serum levels of oxidized low-density lipoprotein (oxLDL) and oxLDL antibody (oLAB) and colorectal cancer risk were investigated in a case-control study nested in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Serum samples and lifestyle information were collected at baseline from 39,242 men and women between 1988 and 1990. Of these, 161 incidents and deaths from colorectal cancer were identified through 1999, and 395 controls were matched for gender, age, and study area. Measurements were taken of serum oxLDL levels in 119 cases and 316 controls and serum oLAB levels in 153 cases and 376 controls. Odds ratios (95% confidence intervals) across quartiles, adjusted for confounding factors, were 1.55 (0.70-3.46), 1.90 (0.84-4.28), and 3.65 (1.50-8.92) for oxLDL (P(trend) = 0.004) and 0.98 (0.54-1.80), 0.75 (0.39-1.48), and 1.68 (0.90-3.13) for oLAB (P(trend) = 0.140). Further adjustment for serum total cholesterol and alpha-tocopherol did not materially change these associations. Odds ratio (95% confidence interval) of the highest quartile of serum oxLDL compared with the lowest quartile was 3.40 (1.09-10.58; P(trend) = 0.045). Analyses restricted to colon cancer cases and corresponding controls yielded similar relationships between serum oxLDL and oLAB levels and risk. In conclusion, higher levels of serum oxLDL may increase risk of colorectal cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/15533907/Serum_oxidized_low_density_lipoprotein_levels_and_risk_of_colorectal_cancer:_a_case_control_study_nested_in_the_Japan_Collaborative_Cohort_Study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=15533907 DB - PRIME DP - Unbound Medicine ER -