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Folate and brain function in the elderly.

Abstract

PURPOSE OF REVIEW

Over the past several decades, folate has emerged as an important nutrient in several key conditions of concern to the elderly. Subclinical levels of folate inadequacy can have significant negative impacts on health in older individuals.

RECENT FINDINGS

Serum and red blood cell folate levels are associated with depression in younger individuals, but the relationship is less clear in older people. However, folate status does predict response to antidepressant treatment in older individuals. Cognitive decline and some forms of dementia, including Alzheimer's disease, are associated with lower folate levels. Supplementation with folic acid can provide cognitive benefits in some circumstances. Folic acid supplementation is generally regarded as safe; however, there remains some concern that high levels of folic acid may exacerbate the neurological consequences of a vitamin B12 deficiency.

SUMMARY

Evidence for the role of folate in depression and dementia in the aged is increasing, although there remains much about mechanisms to be determined.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA.

    Source

    MeSH

    Aged
    Brain
    Cognition
    Dementia
    Depression
    Erythrocytes
    Female
    Folic Acid
    Folic Acid Deficiency
    Humans
    Male
    Vitamin B 12 Deficiency

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, Non-P.H.S.
    Research Support, U.S. Gov't, P.H.S.
    Review

    Language

    eng

    PubMed ID

    15534434

    Citation

    D'Anci, Kristen E., and Irwin H. Rosenberg. "Folate and Brain Function in the Elderly." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 7, no. 6, 2004, pp. 659-64.
    D'Anci KE, Rosenberg IH. Folate and brain function in the elderly. Curr Opin Clin Nutr Metab Care. 2004;7(6):659-64.
    D'Anci, K. E., & Rosenberg, I. H. (2004). Folate and brain function in the elderly. Current Opinion in Clinical Nutrition and Metabolic Care, 7(6), pp. 659-64.
    D'Anci KE, Rosenberg IH. Folate and Brain Function in the Elderly. Curr Opin Clin Nutr Metab Care. 2004;7(6):659-64. PubMed PMID: 15534434.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Folate and brain function in the elderly. AU - D'Anci,Kristen E, AU - Rosenberg,Irwin H, PY - 2004/11/10/pubmed PY - 2005/4/9/medline PY - 2004/11/10/entrez SP - 659 EP - 64 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 7 IS - 6 N2 - PURPOSE OF REVIEW: Over the past several decades, folate has emerged as an important nutrient in several key conditions of concern to the elderly. Subclinical levels of folate inadequacy can have significant negative impacts on health in older individuals. RECENT FINDINGS: Serum and red blood cell folate levels are associated with depression in younger individuals, but the relationship is less clear in older people. However, folate status does predict response to antidepressant treatment in older individuals. Cognitive decline and some forms of dementia, including Alzheimer's disease, are associated with lower folate levels. Supplementation with folic acid can provide cognitive benefits in some circumstances. Folic acid supplementation is generally regarded as safe; however, there remains some concern that high levels of folic acid may exacerbate the neurological consequences of a vitamin B12 deficiency. SUMMARY: Evidence for the role of folate in depression and dementia in the aged is increasing, although there remains much about mechanisms to be determined. SN - 1363-1950 UR - https://www.unboundmedicine.com/medline/citation/15534434/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=15534434 DB - PRIME DP - Unbound Medicine ER -