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Association of early-onset otitis media in infants and exposure to household mould.
Paediatr Perinat Epidemiol. 2004 Nov; 18(6):441-7.PP

Abstract

Otitis media is one of the most common infections of early childhood. Children who first experience acute otitis media at an early age (before 6 months) are at increased risk for recurrent otitis media. This prospective study investigated exposure to measured levels of airborne household mould and the risk of early otitis media in the first 6 months of life among a cohort of infants at high risk for asthma. Between September 1996 and December 1998, women were invited to participate if they had at least one other child with physician-diagnosed asthma. Mothers were given a standardised questionnaire within 4 months of their infant's birth. Airborne mould samples were also taken at this time, and culturable fungi were categorised into four levels according to the report of the Commission of European Communities: 0 (undetectable), 1-499 colony forming units (CFU)/m(3) (low), 500-999 CFU/m(3) (medium), > or =1000 CFU/m(3) (high). Infant respiratory symptoms were collected during quarterly telephone interviews at 6, 9 and 12 months of age. Of the 806 children in the study, 27.8% experienced otitis media before six months of age. Household levels of Penicillium and Cladosporium were modestly associated with the number of otitis media episodes (P = 0.056 and 0.081 respectively). After controlling for potential confounders, Penicillium and Cladosporium were not associated with early otitis media. High levels of 'other' mould (defined as total spore count minus counts for Penicillium, Cladosporium, and yeast) were associated with early otitis media (OR 3.49; 95% CI [1.38, 8.79]). We also found associations between day-care outside of the home and birth during the summer or fall season with early otitis media. This study is suggestive of a relationship between otitis media and mould that warrants further study.

Authors+Show Affiliations

Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520-8034, USA. melinda.pettigrew@yale.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15535820

Citation

Pettigrew, Melinda M., et al. "Association of Early-onset Otitis Media in Infants and Exposure to Household Mould." Paediatric and Perinatal Epidemiology, vol. 18, no. 6, 2004, pp. 441-7.
Pettigrew MM, Gent JF, Triche EW, et al. Association of early-onset otitis media in infants and exposure to household mould. Paediatr Perinat Epidemiol. 2004;18(6):441-7.
Pettigrew, M. M., Gent, J. F., Triche, E. W., Belanger, K. D., Bracken, M. B., & Leaderer, B. P. (2004). Association of early-onset otitis media in infants and exposure to household mould. Paediatric and Perinatal Epidemiology, 18(6), 441-7.
Pettigrew MM, et al. Association of Early-onset Otitis Media in Infants and Exposure to Household Mould. Paediatr Perinat Epidemiol. 2004;18(6):441-7. PubMed PMID: 15535820.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of early-onset otitis media in infants and exposure to household mould. AU - Pettigrew,Melinda M, AU - Gent,Janneane F, AU - Triche,Elizabeth W, AU - Belanger,Kathleen D, AU - Bracken,Michael B, AU - Leaderer,Brian P, PY - 2004/11/13/pubmed PY - 2005/3/25/medline PY - 2004/11/13/entrez SP - 441 EP - 7 JF - Paediatric and perinatal epidemiology JO - Paediatr Perinat Epidemiol VL - 18 IS - 6 N2 - Otitis media is one of the most common infections of early childhood. Children who first experience acute otitis media at an early age (before 6 months) are at increased risk for recurrent otitis media. This prospective study investigated exposure to measured levels of airborne household mould and the risk of early otitis media in the first 6 months of life among a cohort of infants at high risk for asthma. Between September 1996 and December 1998, women were invited to participate if they had at least one other child with physician-diagnosed asthma. Mothers were given a standardised questionnaire within 4 months of their infant's birth. Airborne mould samples were also taken at this time, and culturable fungi were categorised into four levels according to the report of the Commission of European Communities: 0 (undetectable), 1-499 colony forming units (CFU)/m(3) (low), 500-999 CFU/m(3) (medium), > or =1000 CFU/m(3) (high). Infant respiratory symptoms were collected during quarterly telephone interviews at 6, 9 and 12 months of age. Of the 806 children in the study, 27.8% experienced otitis media before six months of age. Household levels of Penicillium and Cladosporium were modestly associated with the number of otitis media episodes (P = 0.056 and 0.081 respectively). After controlling for potential confounders, Penicillium and Cladosporium were not associated with early otitis media. High levels of 'other' mould (defined as total spore count minus counts for Penicillium, Cladosporium, and yeast) were associated with early otitis media (OR 3.49; 95% CI [1.38, 8.79]). We also found associations between day-care outside of the home and birth during the summer or fall season with early otitis media. This study is suggestive of a relationship between otitis media and mould that warrants further study. SN - 0269-5022 UR - https://www.unboundmedicine.com/medline/citation/15535820/Association_of_early_onset_otitis_media_in_infants_and_exposure_to_household_mould_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0269-5022&date=2004&volume=18&issue=6&spage=441 DB - PRIME DP - Unbound Medicine ER -