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Evaluation of PAH bioaccumulation and DNA damage in mussels (Mytilus galloprovincialis) exposed to spilled Prestige crude oil.
Comp Biochem Physiol C Toxicol Pharmacol. 2004 Aug; 138(4):453-60.CB

Abstract

We analyzed the hydrocarbon composition of the Prestige oil as it reached the shores, its solubility in sea water, its bioaccumulation, and the genotoxic damage associated to oil exposure, using Mytilus galloprovincialis as sentinel organism. Mussels were exposed to two oil volumetric ratios (1:500 and 2:500) for 12 days. Great concentrations of total polycyclic aromatic hydrocarbons (TPAH) have been obtained, being in general higher in the samples from the dose of 1:500, both in sea water (55.14 vs. 41.96 microg/l) and mussel tissue (16,993.80 vs. 17,033.00 microg/kg), probably due to the great tendency of these compounds to link to particles in water. Comet assay results reflected an increase in the DNA damage associated to oil exposure, higher in the mussels exposed to the higher aqueous TPAH content. In the view of our results, the importance of the evaluation of biodisponibility, bioaccumulation and DNA damage in the assessment of the effects of xenobiotic pollutants to marine environments could be highlighted.

Authors+Show Affiliations

Unidad de Toxicología, Universidade da Coruña, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15536053

Citation

Pérez-Cadahía, Beatriz, et al. "Evaluation of PAH Bioaccumulation and DNA Damage in Mussels (Mytilus Galloprovincialis) Exposed to Spilled Prestige Crude Oil." Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, vol. 138, no. 4, 2004, pp. 453-60.
Pérez-Cadahía B, Laffon B, Pásaro E, et al. Evaluation of PAH bioaccumulation and DNA damage in mussels (Mytilus galloprovincialis) exposed to spilled Prestige crude oil. Comp Biochem Physiol C Toxicol Pharmacol. 2004;138(4):453-60.
Pérez-Cadahía, B., Laffon, B., Pásaro, E., & Méndez, J. (2004). Evaluation of PAH bioaccumulation and DNA damage in mussels (Mytilus galloprovincialis) exposed to spilled Prestige crude oil. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, 138(4), 453-60.
Pérez-Cadahía B, et al. Evaluation of PAH Bioaccumulation and DNA Damage in Mussels (Mytilus Galloprovincialis) Exposed to Spilled Prestige Crude Oil. Comp Biochem Physiol C Toxicol Pharmacol. 2004;138(4):453-60. PubMed PMID: 15536053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of PAH bioaccumulation and DNA damage in mussels (Mytilus galloprovincialis) exposed to spilled Prestige crude oil. AU - Pérez-Cadahía,Beatriz, AU - Laffon,Blanca, AU - Pásaro,Eduardo, AU - Méndez,Josefina, PY - 2004/05/06/received PY - 2004/07/30/revised PY - 2004/08/04/accepted PY - 2004/11/13/pubmed PY - 2005/3/30/medline PY - 2004/11/13/entrez SP - 453 EP - 60 JF - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP JO - Comp Biochem Physiol C Toxicol Pharmacol VL - 138 IS - 4 N2 - We analyzed the hydrocarbon composition of the Prestige oil as it reached the shores, its solubility in sea water, its bioaccumulation, and the genotoxic damage associated to oil exposure, using Mytilus galloprovincialis as sentinel organism. Mussels were exposed to two oil volumetric ratios (1:500 and 2:500) for 12 days. Great concentrations of total polycyclic aromatic hydrocarbons (TPAH) have been obtained, being in general higher in the samples from the dose of 1:500, both in sea water (55.14 vs. 41.96 microg/l) and mussel tissue (16,993.80 vs. 17,033.00 microg/kg), probably due to the great tendency of these compounds to link to particles in water. Comet assay results reflected an increase in the DNA damage associated to oil exposure, higher in the mussels exposed to the higher aqueous TPAH content. In the view of our results, the importance of the evaluation of biodisponibility, bioaccumulation and DNA damage in the assessment of the effects of xenobiotic pollutants to marine environments could be highlighted. SN - 1532-0456 UR - https://www.unboundmedicine.com/medline/citation/15536053/Evaluation_of_PAH_bioaccumulation_and_DNA_damage_in_mussels__Mytilus_galloprovincialis__exposed_to_spilled_Prestige_crude_oil_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1532-0456(04)00136-X DB - PRIME DP - Unbound Medicine ER -