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Prevention of dementia: lessons from SYST-EUR and PROGRESS.
J Neurol Sci. 2004 Nov 15; 226(1-2):71-4.JN

Abstract

Hypertension is one of the principal risk factors for cerebrovascular diseases, closely correlated also with cognitive decline and dementia. Data from recent therapeutic trials (SYST-EUR, PROGRESS) open the way toward the prevention of dementia (vascular or Alzheimer's type) by antihypertensive treatments. The results of these two studies suggest different mechanisms of action of antihypertensive drugs in the prevention of cognitive decline. The use of angiotensin converting enzyme (ACE) inhibitors, with or without diuretics, resulted in decrease incidence of stroke-related dementia, but dementia without stroke was not reduced. With the dihydropyridine calcium antagonists, a reduction in both Alzheimer's type and vascular dementia was demonstrated.

Authors+Show Affiliations

Department of Geriatrics, Hôpital Broca, CHU Cochin Port-Royal, Université René Descartes, Paris V, 54/56 Rue Pascal, 75013 Paris, France. olivier.hanon@brc.ap-hop-paris.frNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15537524

Citation

Hanon, Olivier, and Françoise Forette. "Prevention of Dementia: Lessons From SYST-EUR and PROGRESS." Journal of the Neurological Sciences, vol. 226, no. 1-2, 2004, pp. 71-4.
Hanon O, Forette F. Prevention of dementia: lessons from SYST-EUR and PROGRESS. J Neurol Sci. 2004;226(1-2):71-4.
Hanon, O., & Forette, F. (2004). Prevention of dementia: lessons from SYST-EUR and PROGRESS. Journal of the Neurological Sciences, 226(1-2), 71-4.
Hanon O, Forette F. Prevention of Dementia: Lessons From SYST-EUR and PROGRESS. J Neurol Sci. 2004 Nov 15;226(1-2):71-4. PubMed PMID: 15537524.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of dementia: lessons from SYST-EUR and PROGRESS. AU - Hanon,Olivier, AU - Forette,Françoise, PY - 2004/11/13/pubmed PY - 2005/1/20/medline PY - 2004/11/13/entrez SP - 71 EP - 4 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 226 IS - 1-2 N2 - Hypertension is one of the principal risk factors for cerebrovascular diseases, closely correlated also with cognitive decline and dementia. Data from recent therapeutic trials (SYST-EUR, PROGRESS) open the way toward the prevention of dementia (vascular or Alzheimer's type) by antihypertensive treatments. The results of these two studies suggest different mechanisms of action of antihypertensive drugs in the prevention of cognitive decline. The use of angiotensin converting enzyme (ACE) inhibitors, with or without diuretics, resulted in decrease incidence of stroke-related dementia, but dementia without stroke was not reduced. With the dihydropyridine calcium antagonists, a reduction in both Alzheimer's type and vascular dementia was demonstrated. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/15537524/Prevention_of_dementia:_lessons_from_SYST_EUR_and_PROGRESS_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(04)00297-7 DB - PRIME DP - Unbound Medicine ER -