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Biomarkers of neurodegenerative disorders: how good are they?
Cell Res. 2004 Oct; 14(5):347-58.CR

Abstract

Biomarkers are very important indicators of normal and abnormal biological processes. Specific changes in pathologies, biochemistries and genetics can give us comprehensive information regarding the nature of any particular disease. A good biomarker should be precise and reliable, distinguishable between normal and interested disease, and differential between different diseases. It is believed that biomarkers have great potential in predicting chances for diseases, aiding in early diagnosis, and setting standards for the development of new remedies to treat diseases. New technologies have enabled scientists to identify biomarkers of several different neurodegenerative diseases. The followings, for instance, are only a few of the many new biomarkers that have been recently identified: the phosphorylated tau protein and aggregated Beta-amyloid peptide for Alzheimer's disease (AD), Alpha-synuclein contained Lewy bodies and altered dopamine transporter (DAT) imaging for Parkinson's disease (PD), SOD mutations for familial amyotrophic lateral sclerosis (ALS), and CAG repeats resulted from Huntington's gene mutations in Huntington's disease (HD). This article will focus on the most-recent findings of biomarkers belonging to the four mentioned neurodegenerative diseases.

Authors+Show Affiliations

Department of Neurology, Baylor College of Medicine, Houston, TX, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15538967

Citation

Rachakonda, Varun, et al. "Biomarkers of Neurodegenerative Disorders: How Good Are They?" Cell Research, vol. 14, no. 5, 2004, pp. 347-58.
Rachakonda V, Pan TH, LE WD. Biomarkers of neurodegenerative disorders: how good are they? Cell Res. 2004;14(5):347-58.
Rachakonda, V., Pan, T. H., & LE, W. D. (2004). Biomarkers of neurodegenerative disorders: how good are they? Cell Research, 14(5), 347-58.
Rachakonda V, Pan TH, LE WD. Biomarkers of Neurodegenerative Disorders: How Good Are They. Cell Res. 2004;14(5):347-58. PubMed PMID: 15538967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biomarkers of neurodegenerative disorders: how good are they? AU - Rachakonda,Varun, AU - Pan,Tian Hong, AU - LE,Wei Dong, PY - 2004/11/13/pubmed PY - 2005/3/23/medline PY - 2004/11/13/entrez SP - 347 EP - 58 JF - Cell research JO - Cell Res VL - 14 IS - 5 N2 - Biomarkers are very important indicators of normal and abnormal biological processes. Specific changes in pathologies, biochemistries and genetics can give us comprehensive information regarding the nature of any particular disease. A good biomarker should be precise and reliable, distinguishable between normal and interested disease, and differential between different diseases. It is believed that biomarkers have great potential in predicting chances for diseases, aiding in early diagnosis, and setting standards for the development of new remedies to treat diseases. New technologies have enabled scientists to identify biomarkers of several different neurodegenerative diseases. The followings, for instance, are only a few of the many new biomarkers that have been recently identified: the phosphorylated tau protein and aggregated Beta-amyloid peptide for Alzheimer's disease (AD), Alpha-synuclein contained Lewy bodies and altered dopamine transporter (DAT) imaging for Parkinson's disease (PD), SOD mutations for familial amyotrophic lateral sclerosis (ALS), and CAG repeats resulted from Huntington's gene mutations in Huntington's disease (HD). This article will focus on the most-recent findings of biomarkers belonging to the four mentioned neurodegenerative diseases. SN - 1001-0602 UR - https://www.unboundmedicine.com/medline/citation/15538967/Biomarkers_of_neurodegenerative_disorders:_how_good_are_they L2 - https://medlineplus.gov/degenerativenervediseases.html DB - PRIME DP - Unbound Medicine ER -