Tags

Type your tag names separated by a space and hit enter

Columnar cell lesions: fine-needle aspiration biopsy features.
Diagn Cytopathol. 2004 Dec; 31(6):370-5.DC

Abstract

Columnar cell lesions (CCLs) have been described histologically. Frequently, they are noted in biopsies performed for calcifications and are associated with an increased risk of malignancy in the presence of atypia. We sought to characterize the cytological features of CCLs in fine-needle aspirations (FNAs). Twenty FNAs with subsequent histology diagnoses of CCL without carcinoma were reviewed retrospectively. Eighteen of 20 cases were classified as "atypical" on cytology; they had cohesive three-dimensional clusters of enlarged polygonal epithelial cells intermixed with myoepithelial cells in the centers and palisading columnar cells peripherally. Five of these had cytological or architectural atypia on subsequent biopsies, but no significant differences were noted among the 18 aspirates. Calcifications (2/18), snouts (9/18), and bipolar nuclei (11/18) were also identified. The remaining 2/20 FNAs were interpreted as negative because of scant cellularity. In conclusion, CCLs have characteristic cytological traits, and because they may be associated with carcinoma, their recognition is important.

Authors+Show Affiliations

Department of Pathology, Division of Cytopathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. aas177@columbia.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15540173

Citation

Saqi, Anjali, et al. "Columnar Cell Lesions: Fine-needle Aspiration Biopsy Features." Diagnostic Cytopathology, vol. 31, no. 6, 2004, pp. 370-5.
Saqi A, Mazziotta R, Hamele-Bena D. Columnar cell lesions: fine-needle aspiration biopsy features. Diagn Cytopathol. 2004;31(6):370-5.
Saqi, A., Mazziotta, R., & Hamele-Bena, D. (2004). Columnar cell lesions: fine-needle aspiration biopsy features. Diagnostic Cytopathology, 31(6), 370-5.
Saqi A, Mazziotta R, Hamele-Bena D. Columnar Cell Lesions: Fine-needle Aspiration Biopsy Features. Diagn Cytopathol. 2004;31(6):370-5. PubMed PMID: 15540173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Columnar cell lesions: fine-needle aspiration biopsy features. AU - Saqi,Anjali, AU - Mazziotta,Robert, AU - Hamele-Bena,Diane, PY - 2004/11/13/pubmed PY - 2005/4/23/medline PY - 2004/11/13/entrez SP - 370 EP - 5 JF - Diagnostic cytopathology JO - Diagn Cytopathol VL - 31 IS - 6 N2 - Columnar cell lesions (CCLs) have been described histologically. Frequently, they are noted in biopsies performed for calcifications and are associated with an increased risk of malignancy in the presence of atypia. We sought to characterize the cytological features of CCLs in fine-needle aspirations (FNAs). Twenty FNAs with subsequent histology diagnoses of CCL without carcinoma were reviewed retrospectively. Eighteen of 20 cases were classified as "atypical" on cytology; they had cohesive three-dimensional clusters of enlarged polygonal epithelial cells intermixed with myoepithelial cells in the centers and palisading columnar cells peripherally. Five of these had cytological or architectural atypia on subsequent biopsies, but no significant differences were noted among the 18 aspirates. Calcifications (2/18), snouts (9/18), and bipolar nuclei (11/18) were also identified. The remaining 2/20 FNAs were interpreted as negative because of scant cellularity. In conclusion, CCLs have characteristic cytological traits, and because they may be associated with carcinoma, their recognition is important. SN - 8755-1039 UR - https://www.unboundmedicine.com/medline/citation/15540173/Columnar_cell_lesions:_fine_needle_aspiration_biopsy_features_ L2 - https://doi.org/10.1002/dc.20158 DB - PRIME DP - Unbound Medicine ER -