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Effects of simvastatin treatment on oxidant/antioxidant state and ultrastructure of streptozotocin-diabetic rat lung.
Cell Biochem Funct. 2005 Nov-Dec; 23(6):421-6.CB

Abstract

In the present study, we investigated the effects of simvastatin, a 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitor, on lipid metabolism, lipid peroxidation, antioxidant enzyme activities and ultrastructure of diabetic rat lung. Diabetes was induced by a single injection of streptozotocin (45 mg kg(-1), i.p.). After 8 weeks induction of diabetes, some control and diabetic rats were treated with simvastatin (10 mg kg(-1) rat day(-1); orally) for 4 weeks. Diabetes resulted in significantly high levels of blood glucose and plasma lipids. Malondialdehyde levels were unchanged after 12-week-old diabetic rats, whereas catalase activity significantly decreased in the lung. Glutathione peroxidase activity and nitric oxide level were significantly elevated in the diabetic lung. Histological analysis of the diabetic lung revealed some deterioration in the structure. Simvastatin treatment reduced plasma lipid levels and partially decreased the severity of hyperglycaemia. Catalase, glutathione peroxidase activities and nitric oxide levels were partially restored and accompanied by improved structure in diabetic lung by the simvastatin treatment. These results suggest that structural disturbances and alteration of antioxidative enzyme activities occurred in diabetic lung. Simvastatin treatment may provide some benefits in the maintenance of antioxidant status and structural organization of diabetes-induced injury of lung.

Authors+Show Affiliations

Ankara University, Faculty of Pharmacy, Department of Pharmacology, Tandogan, Ankara, Turkey. ozansoy@pharmacy.ankara.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15540254

Citation

Ozansoy, Gülgün, et al. "Effects of Simvastatin Treatment On Oxidant/antioxidant State and Ultrastructure of Streptozotocin-diabetic Rat Lung." Cell Biochemistry and Function, vol. 23, no. 6, 2005, pp. 421-6.
Ozansoy G, Güven C, Ceylan A, et al. Effects of simvastatin treatment on oxidant/antioxidant state and ultrastructure of streptozotocin-diabetic rat lung. Cell Biochem Funct. 2005;23(6):421-6.
Ozansoy, G., Güven, C., Ceylan, A., Can, B., Aktan, F., Oz, E., & Gönül, B. (2005). Effects of simvastatin treatment on oxidant/antioxidant state and ultrastructure of streptozotocin-diabetic rat lung. Cell Biochemistry and Function, 23(6), 421-6.
Ozansoy G, et al. Effects of Simvastatin Treatment On Oxidant/antioxidant State and Ultrastructure of Streptozotocin-diabetic Rat Lung. Cell Biochem Funct. 2005 Nov-Dec;23(6):421-6. PubMed PMID: 15540254.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of simvastatin treatment on oxidant/antioxidant state and ultrastructure of streptozotocin-diabetic rat lung. AU - Ozansoy,Gülgün, AU - Güven,Cengiz, AU - Ceylan,Asli, AU - Can,Belgin, AU - Aktan,Fügen, AU - Oz,Eser, AU - Gönül,Bilge, PY - 2004/11/13/pubmed PY - 2005/12/31/medline PY - 2004/11/13/entrez SP - 421 EP - 6 JF - Cell biochemistry and function JO - Cell Biochem Funct VL - 23 IS - 6 N2 - In the present study, we investigated the effects of simvastatin, a 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitor, on lipid metabolism, lipid peroxidation, antioxidant enzyme activities and ultrastructure of diabetic rat lung. Diabetes was induced by a single injection of streptozotocin (45 mg kg(-1), i.p.). After 8 weeks induction of diabetes, some control and diabetic rats were treated with simvastatin (10 mg kg(-1) rat day(-1); orally) for 4 weeks. Diabetes resulted in significantly high levels of blood glucose and plasma lipids. Malondialdehyde levels were unchanged after 12-week-old diabetic rats, whereas catalase activity significantly decreased in the lung. Glutathione peroxidase activity and nitric oxide level were significantly elevated in the diabetic lung. Histological analysis of the diabetic lung revealed some deterioration in the structure. Simvastatin treatment reduced plasma lipid levels and partially decreased the severity of hyperglycaemia. Catalase, glutathione peroxidase activities and nitric oxide levels were partially restored and accompanied by improved structure in diabetic lung by the simvastatin treatment. These results suggest that structural disturbances and alteration of antioxidative enzyme activities occurred in diabetic lung. Simvastatin treatment may provide some benefits in the maintenance of antioxidant status and structural organization of diabetes-induced injury of lung. SN - 0263-6484 UR - https://www.unboundmedicine.com/medline/citation/15540254/Effects_of_simvastatin_treatment_on_oxidant/antioxidant_state_and_ultrastructure_of_streptozotocin_diabetic_rat_lung_ L2 - https://doi.org/10.1002/cbf.1168 DB - PRIME DP - Unbound Medicine ER -