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Atovaquone-proguanil (malarone): an effective treatment for uncomplicated Plasmodium falciparum malaria in travelers from Denmark.
J Travel Med. 2004 Jul-Aug; 11(4):220-3.JT

Abstract

BACKGROUND

Previous experience with unacceptable adverse effects with mefloquine as treatment for uncomplicated Plasmodium falciparum malaria prompted an evaluation of the effectiveness and side effects of atovaquone-proguanil (Malarone) in a hospital setting.

METHODS

Atovaquone-proguanil was given as standard treatment (1,000/400 mgq.d. for 3 days) to 50 adults who had traveled in Africa and returned with uncomplicated Plasmodium falciparum malaria. Half of the treated patients were African and had lived outside Africa for varying periods of time; the other half were Danish-born persons without any previous immunity towards malaria.

RESULTS

All patients treated with Malarone were cured without complications. The mean fever clearance times differed among the groups and according to various degrees of prior exposure to malaria and ranged from 1.3 to 2.2 days. Adverse effects during treatment were mild, and were likely to be due to the malaria itself. Fourteen people who had acquired falciparum malaria in spite of taking proguanil-chloroquine prophylaxis were also cured uneventfully without recrudescence.

CONCLUSIONS

Malarone appears to be an effective, safe and acceptable oral treatment for uncomplicated malaria.

Authors+Show Affiliations

Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

15541224

Citation

Thybo, Sören, et al. "Atovaquone-proguanil (malarone): an Effective Treatment for Uncomplicated Plasmodium Falciparum Malaria in Travelers From Denmark." Journal of Travel Medicine, vol. 11, no. 4, 2004, pp. 220-3.
Thybo S, Gjorup I, Ronn AM, et al. Atovaquone-proguanil (malarone): an effective treatment for uncomplicated Plasmodium falciparum malaria in travelers from Denmark. J Travel Med. 2004;11(4):220-3.
Thybo, S., Gjorup, I., Ronn, A. M., Meyrowitsch, D., & Bygberg, I. C. (2004). Atovaquone-proguanil (malarone): an effective treatment for uncomplicated Plasmodium falciparum malaria in travelers from Denmark. Journal of Travel Medicine, 11(4), 220-3.
Thybo S, et al. Atovaquone-proguanil (malarone): an Effective Treatment for Uncomplicated Plasmodium Falciparum Malaria in Travelers From Denmark. J Travel Med. 2004 Jul-Aug;11(4):220-3. PubMed PMID: 15541224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atovaquone-proguanil (malarone): an effective treatment for uncomplicated Plasmodium falciparum malaria in travelers from Denmark. AU - Thybo,Sören, AU - Gjorup,Ida, AU - Ronn,Anita M, AU - Meyrowitsch,Dan, AU - Bygberg,Ib C, PY - 2004/11/16/pubmed PY - 2004/12/16/medline PY - 2004/11/16/entrez SP - 220 EP - 3 JF - Journal of travel medicine JO - J Travel Med VL - 11 IS - 4 N2 - BACKGROUND: Previous experience with unacceptable adverse effects with mefloquine as treatment for uncomplicated Plasmodium falciparum malaria prompted an evaluation of the effectiveness and side effects of atovaquone-proguanil (Malarone) in a hospital setting. METHODS: Atovaquone-proguanil was given as standard treatment (1,000/400 mgq.d. for 3 days) to 50 adults who had traveled in Africa and returned with uncomplicated Plasmodium falciparum malaria. Half of the treated patients were African and had lived outside Africa for varying periods of time; the other half were Danish-born persons without any previous immunity towards malaria. RESULTS: All patients treated with Malarone were cured without complications. The mean fever clearance times differed among the groups and according to various degrees of prior exposure to malaria and ranged from 1.3 to 2.2 days. Adverse effects during treatment were mild, and were likely to be due to the malaria itself. Fourteen people who had acquired falciparum malaria in spite of taking proguanil-chloroquine prophylaxis were also cured uneventfully without recrudescence. CONCLUSIONS: Malarone appears to be an effective, safe and acceptable oral treatment for uncomplicated malaria. SN - 1195-1982 UR - https://www.unboundmedicine.com/medline/citation/15541224/Atovaquone_proguanil__malarone_:_an_effective_treatment_for_uncomplicated_Plasmodium_falciparum_malaria_in_travelers_from_Denmark_ L2 - https://academic.oup.com/jtm/article-lookup/doi/10.2310/7060.2004.19005 DB - PRIME DP - Unbound Medicine ER -