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Effects of chlorogenic acid and its metabolites on the sleep-wakefulness cycle in rats.
Eur J Pharmacol. 2004 Nov 19; 504(3):185-9.EJ

Abstract

The effect of chlorogenic acid on the sleep-wakefulness cycle in rats was investigated in comparison with those of caffeic acid (the metabolite of chlorogenic acid) and dihydrocaffeic acid (the metabolite of caffeic acid). A significant prolongation of sleep latency was observed with chlorogenic acid and caffeic acid at a dose of 500 and 200 mg/kg, respectively. On the other hand, no remarkable effects were observed with dihydrocaffeic acid even at a dose of 500 mg/kg. Caffeine caused a significant increase in sleep latency and waking time and decrease in non-rapid eye movement sleep time at a dose of 10 mg/kg. In contrast, chlorogenic acid and its metabolites had no significant effects on each sleep state. From these results, it may be concluded that chrologenic acid caused a mild arousal effect compared with that of caffeine, and the effect of chlorogenic acid may have occurred through its metabolite caffeic acid.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima-naka 1-1-1, Okayama 700-8530, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15541420

Citation

Shinomiya, Kazuaki, et al. "Effects of Chlorogenic Acid and Its Metabolites On the Sleep-wakefulness Cycle in Rats." European Journal of Pharmacology, vol. 504, no. 3, 2004, pp. 185-9.
Shinomiya K, Omichi J, Ohnishi R, et al. Effects of chlorogenic acid and its metabolites on the sleep-wakefulness cycle in rats. Eur J Pharmacol. 2004;504(3):185-9.
Shinomiya, K., Omichi, J., Ohnishi, R., Ito, H., Yoshida, T., & Kamei, C. (2004). Effects of chlorogenic acid and its metabolites on the sleep-wakefulness cycle in rats. European Journal of Pharmacology, 504(3), 185-9.
Shinomiya K, et al. Effects of Chlorogenic Acid and Its Metabolites On the Sleep-wakefulness Cycle in Rats. Eur J Pharmacol. 2004 Nov 19;504(3):185-9. PubMed PMID: 15541420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of chlorogenic acid and its metabolites on the sleep-wakefulness cycle in rats. AU - Shinomiya,Kazuaki, AU - Omichi,Junji, AU - Ohnishi,Ryoko, AU - Ito,Hideyuki, AU - Yoshida,Takashi, AU - Kamei,Chiaki, PY - 2004/07/22/received PY - 2004/09/15/revised PY - 2004/09/21/accepted PY - 2004/11/16/pubmed PY - 2005/10/1/medline PY - 2004/11/16/entrez SP - 185 EP - 9 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 504 IS - 3 N2 - The effect of chlorogenic acid on the sleep-wakefulness cycle in rats was investigated in comparison with those of caffeic acid (the metabolite of chlorogenic acid) and dihydrocaffeic acid (the metabolite of caffeic acid). A significant prolongation of sleep latency was observed with chlorogenic acid and caffeic acid at a dose of 500 and 200 mg/kg, respectively. On the other hand, no remarkable effects were observed with dihydrocaffeic acid even at a dose of 500 mg/kg. Caffeine caused a significant increase in sleep latency and waking time and decrease in non-rapid eye movement sleep time at a dose of 10 mg/kg. In contrast, chlorogenic acid and its metabolites had no significant effects on each sleep state. From these results, it may be concluded that chrologenic acid caused a mild arousal effect compared with that of caffeine, and the effect of chlorogenic acid may have occurred through its metabolite caffeic acid. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/15541420/Effects_of_chlorogenic_acid_and_its_metabolites_on_the_sleep_wakefulness_cycle_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(04)01121-5 DB - PRIME DP - Unbound Medicine ER -