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Use of SPE and LC/TIS/MS/MS for rapid detection and quantitation of ketamine and its metabolite, norketamine, in urine.
Forensic Sci Int. 2005 Jan 06; 147(1):81-8.FS

Abstract

Ketamine (K) has become more and more popular for drug abuse in recent years. A lot of pre-treatment work such as extraction and derivatizing increase difficulties in the tests for ketamine in biological specimens. A rapid method to detect and quantitate ketamine and its metabolite norketamine in urine used deuterated dilution followed by solid phase extraction and liquid chromatography/TurboIonSpray/tandem mass spectrometry (LC/TIS/MS/MS) is described. Control recovery for both low and high concentrations can reach to 90%. Ten ketamine positive urines were examinated by this method. Concentrations ranged from 114 to 2925 ng/mL and from 453 to 9805 ng/mL for norketamine. The method was sensitive, specific, accurate and provided easy operation to detect and quantitate ketamine and its metabolites in urine.

Authors+Show Affiliations

Identification Division, Criminal Investigation Bureau, No. 5, Lane 553, Sector 4, Chung Hsiao E. Road, Taipei, Taiwan, ROC. kaung@email.cib.gov.twNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15541595

Citation

Wang, Kaung-Chaun, et al. "Use of SPE and LC/TIS/MS/MS for Rapid Detection and Quantitation of Ketamine and Its Metabolite, Norketamine, in Urine." Forensic Science International, vol. 147, no. 1, 2005, pp. 81-8.
Wang KC, Shih TS, Cheng SG. Use of SPE and LC/TIS/MS/MS for rapid detection and quantitation of ketamine and its metabolite, norketamine, in urine. Forensic Sci Int. 2005;147(1):81-8.
Wang, K. C., Shih, T. S., & Cheng, S. G. (2005). Use of SPE and LC/TIS/MS/MS for rapid detection and quantitation of ketamine and its metabolite, norketamine, in urine. Forensic Science International, 147(1), 81-8.
Wang KC, Shih TS, Cheng SG. Use of SPE and LC/TIS/MS/MS for Rapid Detection and Quantitation of Ketamine and Its Metabolite, Norketamine, in Urine. Forensic Sci Int. 2005 Jan 6;147(1):81-8. PubMed PMID: 15541595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of SPE and LC/TIS/MS/MS for rapid detection and quantitation of ketamine and its metabolite, norketamine, in urine. AU - Wang,Kaung-Chaun, AU - Shih,Tuo-Shi, AU - Cheng,Sheaw-Guey, PY - 2003/08/28/received PY - 2004/03/29/accepted PY - 2004/11/16/pubmed PY - 2005/2/11/medline PY - 2004/11/16/entrez SP - 81 EP - 8 JF - Forensic science international JO - Forensic Sci Int VL - 147 IS - 1 N2 - Ketamine (K) has become more and more popular for drug abuse in recent years. A lot of pre-treatment work such as extraction and derivatizing increase difficulties in the tests for ketamine in biological specimens. A rapid method to detect and quantitate ketamine and its metabolite norketamine in urine used deuterated dilution followed by solid phase extraction and liquid chromatography/TurboIonSpray/tandem mass spectrometry (LC/TIS/MS/MS) is described. Control recovery for both low and high concentrations can reach to 90%. Ten ketamine positive urines were examinated by this method. Concentrations ranged from 114 to 2925 ng/mL and from 453 to 9805 ng/mL for norketamine. The method was sensitive, specific, accurate and provided easy operation to detect and quantitate ketamine and its metabolites in urine. SN - 0379-0738 UR - https://www.unboundmedicine.com/medline/citation/15541595/Use_of_SPE_and_LC/TIS/MS/MS_for_rapid_detection_and_quantitation_of_ketamine_and_its_metabolite_norketamine_in_urine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0379073804002294 DB - PRIME DP - Unbound Medicine ER -