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The homozygote AA genotype of the alpha1-antichymotrypsin gene may confer protection against early-onset Parkinson's disease in women.
Parkinsonism Relat Disord. 2004 Dec; 10(8):469-73.PR

Abstract

There has been increasing evidence suggesting that inflammatory response maybe involved in the pathogenesis of Parkinson's disease (PD). Alpha1-antichymotrypsin gene (ACT) has been regarded as a susceptibility factor for PD in the past, but the evidence remains controversial. This case-control study was designed to investigate the association of alpha1-antichymotrypsin gene (ACT) polymorphism between 210 Taiwanese patients with clinical definite sporadic PD and 260 controls, matched by age and sex. There were no differences of allelic frequency (A and T) and genotype polymorphism (AA, AT and TT) of the ACT in PD patients from the controls. However, there were significantly fewer early-onset PD (onset age younger than 60 years) or PD women carrying the homozygote AA genotype (ACT-AA) than in controls (p=0.046 and 0.044, respectively). Further analysis revealed that the reduced risk of ACT-AA was particularly significant among PD women with the onset age younger than 60 years (OR=0.796, 95% CI=0.749-0.847, p<0.0001). This study shows that ACT-AA may confer a modest protection against developing early-onset PD in women.

Authors+Show Affiliations

Department of Neurology, Chushang Show-Chwan Hospital, 75 Sec. 2 Chi-Shang Road, Chushang Jenn, Nantou 557, Taiwan. cs6682@csshow.org.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15542006

Citation

Lin, J J., et al. "The Homozygote AA Genotype of the Alpha1-antichymotrypsin Gene May Confer Protection Against Early-onset Parkinson's Disease in Women." Parkinsonism & Related Disorders, vol. 10, no. 8, 2004, pp. 469-73.
Lin JJ, Yueh KC, Chang CY, et al. The homozygote AA genotype of the alpha1-antichymotrypsin gene may confer protection against early-onset Parkinson's disease in women. Parkinsonism Relat Disord. 2004;10(8):469-73.
Lin, J. J., Yueh, K. C., Chang, C. Y., Chen, C. H., & Lin, S. Z. (2004). The homozygote AA genotype of the alpha1-antichymotrypsin gene may confer protection against early-onset Parkinson's disease in women. Parkinsonism & Related Disorders, 10(8), 469-73.
Lin JJ, et al. The Homozygote AA Genotype of the Alpha1-antichymotrypsin Gene May Confer Protection Against Early-onset Parkinson's Disease in Women. Parkinsonism Relat Disord. 2004;10(8):469-73. PubMed PMID: 15542006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The homozygote AA genotype of the alpha1-antichymotrypsin gene may confer protection against early-onset Parkinson's disease in women. AU - Lin,J J, AU - Yueh,K C, AU - Chang,C Y, AU - Chen,C H, AU - Lin,S Z, PY - 2004/11/16/pubmed PY - 2005/1/12/medline PY - 2004/11/16/entrez SP - 469 EP - 73 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 10 IS - 8 N2 - There has been increasing evidence suggesting that inflammatory response maybe involved in the pathogenesis of Parkinson's disease (PD). Alpha1-antichymotrypsin gene (ACT) has been regarded as a susceptibility factor for PD in the past, but the evidence remains controversial. This case-control study was designed to investigate the association of alpha1-antichymotrypsin gene (ACT) polymorphism between 210 Taiwanese patients with clinical definite sporadic PD and 260 controls, matched by age and sex. There were no differences of allelic frequency (A and T) and genotype polymorphism (AA, AT and TT) of the ACT in PD patients from the controls. However, there were significantly fewer early-onset PD (onset age younger than 60 years) or PD women carrying the homozygote AA genotype (ACT-AA) than in controls (p=0.046 and 0.044, respectively). Further analysis revealed that the reduced risk of ACT-AA was particularly significant among PD women with the onset age younger than 60 years (OR=0.796, 95% CI=0.749-0.847, p<0.0001). This study shows that ACT-AA may confer a modest protection against developing early-onset PD in women. SN - 1353-8020 UR - https://www.unboundmedicine.com/medline/citation/15542006/The_homozygote_AA_genotype_of_the_alpha1_antichymotrypsin_gene_may_confer_protection_against_early_onset_Parkinson's_disease_in_women_ DB - PRIME DP - Unbound Medicine ER -