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Serum C-reactive protein (CRP) levels and insulin resistance in non-obese women with polycystic ovarian syndrome, and effect of bicalutamide on hirsutism, CRP levels and insulin resistance.
Horm Res. 2004; 62(6):283-7.HR

Abstract

BACKGROUND/AIMS

Insulin resistance is associated with serum C-reactive protein (CRP) levels. We aimed to evaluate the effect of bicalutamide on insulin resistance and serum CRP levels in non-obese polycystic ovarian syndrome (PCOS) patients.

METHODS

40 non-obese patients (BMI < or =25 kg/m2) with PCOS and, 40 age- and BMI-matched healthy women were studied. Patients received bicalutamide orally at the dose of 25 mg/day. Serum CRP levels were measured with immunometric assay. Homeostasis model assessment (HOMA-IR) index was used for insulin resistance.

RESULTS

Mean Ferriman-Gallwey score (FGS) (p = 0.001), insulin (p = 0.001), serum glucose (p = 0.001), prolactin (p < 0.003), total (p < 0.04) and free testosterone (p = 0.001) and free androgen index (FAI) levels (p = 0.001) of PCOS subjects were higher than in the control group. Mean HOMA-IR of PCOS patients was higher than in control subjects (2.43 +/- 1.2 and 0.94 +/- 0.37, p = 0.001). CRP levels in subjects with PCOS was also higher than in control subjects (4.27 +/- 1.33 and 0.98 +/- 0.19, p = 0.001). After bicalutamide treatment, FGS, free and total testosterone and FAI decreased (p = 0.001). HOMA-IR, prolactin and CRP levels did not show any statistical difference with bicalutamide treatment.

CONCLUSIONS

PCOS patients had insulin resistance and a high CRP level. Bicalutamide treatment did not influence insulin resistance and CRP level in PCOS, and this ineffectiveness of bicalutamide on CRP levels may be the result of insulin resistance and/or high prolactin levels at this time.

Authors+Show Affiliations

Bahceci M
Department of Endocrinology, Dicle University School of Medicine, Diyarbakir, Turkey. mbahceci@dicle.edu.tr
Tuzcu A
No affiliation info available
Canoruc N
No affiliation info available
Tuzun Y
No affiliation info available
Kidir V
No affiliation info available
Aslan C
No affiliation info available

MeSH

AdultAndrogen AntagonistsAnilidesAnthropometryBlood GlucoseC-Reactive ProteinFemaleHirsutismHormonesHumansInsulin ResistanceLipidsNitrilesPolycystic Ovary SyndromeTosyl Compounds

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

15542929

Citation

Bahceci, Mithat, et al. "Serum C-reactive Protein (CRP) Levels and Insulin Resistance in Non-obese Women With Polycystic Ovarian Syndrome, and Effect of Bicalutamide On Hirsutism, CRP Levels and Insulin Resistance." Hormone Research, vol. 62, no. 6, 2004, pp. 283-7.
Bahceci M, Tuzcu A, Canoruc N, et al. Serum C-reactive protein (CRP) levels and insulin resistance in non-obese women with polycystic ovarian syndrome, and effect of bicalutamide on hirsutism, CRP levels and insulin resistance. Horm Res. 2004;62(6):283-7.
Bahceci, M., Tuzcu, A., Canoruc, N., Tuzun, Y., Kidir, V., & Aslan, C. (2004). Serum C-reactive protein (CRP) levels and insulin resistance in non-obese women with polycystic ovarian syndrome, and effect of bicalutamide on hirsutism, CRP levels and insulin resistance. Hormone Research, 62(6), 283-7.
Bahceci M, et al. Serum C-reactive Protein (CRP) Levels and Insulin Resistance in Non-obese Women With Polycystic Ovarian Syndrome, and Effect of Bicalutamide On Hirsutism, CRP Levels and Insulin Resistance. Horm Res. 2004;62(6):283-7. PubMed PMID: 15542929.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum C-reactive protein (CRP) levels and insulin resistance in non-obese women with polycystic ovarian syndrome, and effect of bicalutamide on hirsutism, CRP levels and insulin resistance. AU - Bahceci,Mithat, AU - Tuzcu,Alpaslan, AU - Canoruc,Naime, AU - Tuzun,Yekta, AU - Kidir,Veysel, AU - Aslan,Cetin, Y1 - 2004/11/09/ PY - 2003/12/29/received PY - 2004/09/05/accepted PY - 2004/11/16/pubmed PY - 2005/4/20/medline PY - 2004/11/16/entrez SP - 283 EP - 7 JF - Hormone research JO - Horm Res VL - 62 IS - 6 N2 - BACKGROUND/AIMS: Insulin resistance is associated with serum C-reactive protein (CRP) levels. We aimed to evaluate the effect of bicalutamide on insulin resistance and serum CRP levels in non-obese polycystic ovarian syndrome (PCOS) patients. METHODS: 40 non-obese patients (BMI < or =25 kg/m2) with PCOS and, 40 age- and BMI-matched healthy women were studied. Patients received bicalutamide orally at the dose of 25 mg/day. Serum CRP levels were measured with immunometric assay. Homeostasis model assessment (HOMA-IR) index was used for insulin resistance. RESULTS: Mean Ferriman-Gallwey score (FGS) (p = 0.001), insulin (p = 0.001), serum glucose (p = 0.001), prolactin (p < 0.003), total (p < 0.04) and free testosterone (p = 0.001) and free androgen index (FAI) levels (p = 0.001) of PCOS subjects were higher than in the control group. Mean HOMA-IR of PCOS patients was higher than in control subjects (2.43 +/- 1.2 and 0.94 +/- 0.37, p = 0.001). CRP levels in subjects with PCOS was also higher than in control subjects (4.27 +/- 1.33 and 0.98 +/- 0.19, p = 0.001). After bicalutamide treatment, FGS, free and total testosterone and FAI decreased (p = 0.001). HOMA-IR, prolactin and CRP levels did not show any statistical difference with bicalutamide treatment. CONCLUSIONS: PCOS patients had insulin resistance and a high CRP level. Bicalutamide treatment did not influence insulin resistance and CRP level in PCOS, and this ineffectiveness of bicalutamide on CRP levels may be the result of insulin resistance and/or high prolactin levels at this time. SN - 0301-0163 UR - https://www.unboundmedicine.com/medline/citation/15542929/Serum_C_reactive_protein__CRP__levels_and_insulin_resistance_in_non_obese_women_with_polycystic_ovarian_syndrome_and_effect_of_bicalutamide_on_hirsutism_CRP_levels_and_insulin_resistance_ DB - PRIME DP - Unbound Medicine ER -