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Plasma homocysteine, vitamin B12 and folate in Alzheimer's patients and healthy Arabs in Israel.

Abstract

High plasma homocysteine (tHcy) is a risk factor for cardiovascular disease and stroke and Alzheimer's disease (AD). An inverse relationship has been reported between tHcy and plasma B12 and folate levels. Seventy-nine AD patients and 156 controls from three Arab villages in northern Israel participated. Plasma tHcy, B12 and folate levels were determined. Data were analyzed using univariate statistical tests and logistical regression with confounders. tHcy was significantly higher in AD patients (20.6+/-8.7 micromol/l) than in controls (16.4+/-6.5 micromol/l) (p=0.03) after correction for year of birth, gender and smoking status. Plasma B12 (322.9+/-136.0/350.5+/-175.3 pmol/l) and plasma folate (4.5+/-3.8/4.9+/-2.6 nmol/l) levels did not differ significantly between AD patients and controls. Subjects in the highest tHcy tertile or in the lowest B12 and folate tertiles did not have greater risk to develop AD. In this population residing in Arab villages in northern Israel, tHcy levels were significantly higher among AD patients than in controls. Plasma B12 and folate levels were lower among cases but were not significant. There was not a significant association between plasma tHcy, B12 and folate levels in controls or AD patients. High levels of tHcy may suggest the need for folate and vitamin B12 supplementation in this population.

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  • Authors+Show Affiliations

    ,

    Department of Geriatric Medicine, Chaim Sheba Medical Center, Affiliated to the Tel-Aviv University, Sackler School of Medicine, Tel Hashomer, Israel. exm42@sheba.health.gov.il

    , , , , , , , , ,

    Source

    Journal of the neurological sciences 227:1 2004 Dec 15 pg 109-13

    MeSH

    Aged
    Aged, 80 and over
    Alzheimer Disease
    Arabs
    Case-Control Studies
    Confidence Intervals
    Female
    Folic Acid
    Homocysteine
    Humans
    Israel
    Male
    Odds Ratio
    Vitamin B 12

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15546600

    Citation

    Mizrahi, E H., et al. "Plasma Homocysteine, Vitamin B12 and Folate in Alzheimer's Patients and Healthy Arabs in Israel." Journal of the Neurological Sciences, vol. 227, no. 1, 2004, pp. 109-13.
    Mizrahi EH, Bowirrat A, Jacobsen DW, et al. Plasma homocysteine, vitamin B12 and folate in Alzheimer's patients and healthy Arabs in Israel. J Neurol Sci. 2004;227(1):109-13.
    Mizrahi, E. H., Bowirrat, A., Jacobsen, D. W., Korczyn, A. D., Traore, F., Petot, G. J., ... Friedland, R. P. (2004). Plasma homocysteine, vitamin B12 and folate in Alzheimer's patients and healthy Arabs in Israel. Journal of the Neurological Sciences, 227(1), pp. 109-13.
    Mizrahi EH, et al. Plasma Homocysteine, Vitamin B12 and Folate in Alzheimer's Patients and Healthy Arabs in Israel. J Neurol Sci. 2004 Dec 15;227(1):109-13. PubMed PMID: 15546600.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Plasma homocysteine, vitamin B12 and folate in Alzheimer's patients and healthy Arabs in Israel. AU - Mizrahi,E H, AU - Bowirrat,A, AU - Jacobsen,D W, AU - Korczyn,A D, AU - Traore,F, AU - Petot,G J, AU - Lerner,A J, AU - Debanne,S M, AU - Adunsky,A, AU - Dibello,P M, AU - Friedland,R P, PY - 2003/09/22/received PY - 2004/08/26/revised PY - 2004/08/26/accepted PY - 2004/11/18/pubmed PY - 2005/2/16/medline PY - 2004/11/18/entrez SP - 109 EP - 13 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 227 IS - 1 N2 - High plasma homocysteine (tHcy) is a risk factor for cardiovascular disease and stroke and Alzheimer's disease (AD). An inverse relationship has been reported between tHcy and plasma B12 and folate levels. Seventy-nine AD patients and 156 controls from three Arab villages in northern Israel participated. Plasma tHcy, B12 and folate levels were determined. Data were analyzed using univariate statistical tests and logistical regression with confounders. tHcy was significantly higher in AD patients (20.6+/-8.7 micromol/l) than in controls (16.4+/-6.5 micromol/l) (p=0.03) after correction for year of birth, gender and smoking status. Plasma B12 (322.9+/-136.0/350.5+/-175.3 pmol/l) and plasma folate (4.5+/-3.8/4.9+/-2.6 nmol/l) levels did not differ significantly between AD patients and controls. Subjects in the highest tHcy tertile or in the lowest B12 and folate tertiles did not have greater risk to develop AD. In this population residing in Arab villages in northern Israel, tHcy levels were significantly higher among AD patients than in controls. Plasma B12 and folate levels were lower among cases but were not significant. There was not a significant association between plasma tHcy, B12 and folate levels in controls or AD patients. High levels of tHcy may suggest the need for folate and vitamin B12 supplementation in this population. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/15546600/Plasma_homocysteine_vitamin_B12_and_folate_in_Alzheimer's_patients_and_healthy_Arabs_in_Israel_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(04)00281-3 DB - PRIME DP - Unbound Medicine ER -