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Selenium and colorectal adenoma: results of a pooled analysis.
J Natl Cancer Inst 2004; 96(22):1669-75JNCI

Abstract

BACKGROUND

Secondary analyses of data from a large randomized clinical trial have suggested that intake of the trace element selenium reduces risk of colorectal neoplasia, but epidemiologic studies have not shown a consistent protective association.

METHODS

We conducted a combined analysis of data from three randomized trials--the Wheat Bran Fiber Trial, the Polyp Prevention Trial, and the Polyp Prevention Study--which tested the effects of various nutritional interventions for colorectal adenoma prevention among participants who recently had an adenoma removed during colonoscopy. Selenium concentrations were measured from blood specimens from a total of 1763 trial participants, and quartiles of baseline selenium were established from the pooled data. To estimate the association between baseline selenium and colorectal adenoma risk, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression modeling. All statistical tests were two-sided.

RESULTS

Individual study results among participants whose blood selenium concentrations were in the highest versus the lowest quartile varied in magnitude (Polyp Prevention Trial: OR = 0.67, 95% CI = 0.43 to 1.05; P(trend) = .21; Wheat Bran Fiber Trial: OR = 0.66, 95% CI = 0.40 to 1.10; P(trend) = .13, and Polyp Prevention Study: OR = 0.57, 95% CI = 0.34 to 0.95, P(trend) = .04). Analyses of the pooled data showed that individuals whose blood selenium values were in the highest quartile (median = 150 ng/mL) had statistically significantly lower odds of developing a new adenoma compared with those in the lowest quartile (OR = 0.66, 95% CI = 0.50 to 0.87; P(trend) = .006).

CONCLUSIONS

The inverse association between higher blood selenium concentration and adenoma risk supports previous findings indicating that higher selenium status may be related to decreased risk of colorectal cancer.

Authors+Show Affiliations

Arizona Cancer Center, University of Arizona, P.O. Box 245024, Tucson, AZ 85724-5024, USA. jacobse@u.arizona.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15547179

Citation

Jacobs, Elizabeth T., et al. "Selenium and Colorectal Adenoma: Results of a Pooled Analysis." Journal of the National Cancer Institute, vol. 96, no. 22, 2004, pp. 1669-75.
Jacobs ET, Jiang R, Alberts DS, et al. Selenium and colorectal adenoma: results of a pooled analysis. J Natl Cancer Inst. 2004;96(22):1669-75.
Jacobs, E. T., Jiang, R., Alberts, D. S., Greenberg, E. R., Gunter, E. W., Karagas, M. R., ... Martínez, M. E. (2004). Selenium and colorectal adenoma: results of a pooled analysis. Journal of the National Cancer Institute, 96(22), pp. 1669-75.
Jacobs ET, et al. Selenium and Colorectal Adenoma: Results of a Pooled Analysis. J Natl Cancer Inst. 2004 Nov 17;96(22):1669-75. PubMed PMID: 15547179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium and colorectal adenoma: results of a pooled analysis. AU - Jacobs,Elizabeth T, AU - Jiang,Ruiyun, AU - Alberts,David S, AU - Greenberg,E Robert, AU - Gunter,Elaine W, AU - Karagas,Margaret R, AU - Lanza,Elaine, AU - Ratnasinghe,Luke, AU - Reid,Mary E, AU - Schatzkin,Arthur, AU - Smith-Warner,Stephanie A, AU - Wallace,Kristin, AU - Martínez,María Elena, PY - 2004/11/18/pubmed PY - 2004/12/16/medline PY - 2004/11/18/entrez SP - 1669 EP - 75 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 96 IS - 22 N2 - BACKGROUND: Secondary analyses of data from a large randomized clinical trial have suggested that intake of the trace element selenium reduces risk of colorectal neoplasia, but epidemiologic studies have not shown a consistent protective association. METHODS: We conducted a combined analysis of data from three randomized trials--the Wheat Bran Fiber Trial, the Polyp Prevention Trial, and the Polyp Prevention Study--which tested the effects of various nutritional interventions for colorectal adenoma prevention among participants who recently had an adenoma removed during colonoscopy. Selenium concentrations were measured from blood specimens from a total of 1763 trial participants, and quartiles of baseline selenium were established from the pooled data. To estimate the association between baseline selenium and colorectal adenoma risk, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression modeling. All statistical tests were two-sided. RESULTS: Individual study results among participants whose blood selenium concentrations were in the highest versus the lowest quartile varied in magnitude (Polyp Prevention Trial: OR = 0.67, 95% CI = 0.43 to 1.05; P(trend) = .21; Wheat Bran Fiber Trial: OR = 0.66, 95% CI = 0.40 to 1.10; P(trend) = .13, and Polyp Prevention Study: OR = 0.57, 95% CI = 0.34 to 0.95, P(trend) = .04). Analyses of the pooled data showed that individuals whose blood selenium values were in the highest quartile (median = 150 ng/mL) had statistically significantly lower odds of developing a new adenoma compared with those in the lowest quartile (OR = 0.66, 95% CI = 0.50 to 0.87; P(trend) = .006). CONCLUSIONS: The inverse association between higher blood selenium concentration and adenoma risk supports previous findings indicating that higher selenium status may be related to decreased risk of colorectal cancer. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/15547179/Selenium_and_colorectal_adenoma:_results_of_a_pooled_analysis_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djh310 DB - PRIME DP - Unbound Medicine ER -