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Post-training intrabasolateral amygdala infusions of dopamine modulate consolidation of inhibitory avoidance memory: involvement of noradrenergic and cholinergic systems.
Eur J Neurosci. 2004 Nov; 20(10):2804-10.EJ

Abstract

There is extensive evidence that several neurotransmitter systems within the basolateral amygdala (BLA) influence memory consolidation. The present study investigated the influence of dopamine (DA) in the BLA on the consolidation of memory for inhibitory avoidance (IA) training. Male Sprague-Dawley rats (approximately 300 g) were trained on a step-through IA task and, 48 h later, tested for retention as indexed by their latencies to enter the shock compartment on the test day. Drugs were infused into the BLA or central amygdala nucleus (CEA) immediately or 3 h after training via bilateral cannulae. DA infused into the BLA immediately after training enhanced retention, whereas DA infused into the BLA 3 h after training or into the CEA did not affect retention. Infusions of the dopaminergic antagonist cis-Flupenthixol together with DA blocked the DA-induced memory enhancement. Immediate post-training intra-BLA infusions of the D1 receptor antagonist SCH 23390 or the D2 receptor antagonist sulpiride impaired retention. beta-adrenergic or muscarinic cholinergic receptor antagonists coinfused into the BLA with DA blocked the memory enhancing effects of DA. These findings indicate that dopaminergic activation within the BLA modulates memory consolidation and that the modulation involves activation of both D1 and D2 receptors and concurrent activation of beta-adrenergic and cholinergic influences within the BLA.

Authors+Show Affiliations

Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800, USA. rlalumie@uci.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15548223

Citation

Lalumiere, Ryan T., et al. "Post-training Intrabasolateral Amygdala Infusions of Dopamine Modulate Consolidation of Inhibitory Avoidance Memory: Involvement of Noradrenergic and Cholinergic Systems." The European Journal of Neuroscience, vol. 20, no. 10, 2004, pp. 2804-10.
Lalumiere RT, Nguyen LT, McGaugh JL. Post-training intrabasolateral amygdala infusions of dopamine modulate consolidation of inhibitory avoidance memory: involvement of noradrenergic and cholinergic systems. Eur J Neurosci. 2004;20(10):2804-10.
Lalumiere, R. T., Nguyen, L. T., & McGaugh, J. L. (2004). Post-training intrabasolateral amygdala infusions of dopamine modulate consolidation of inhibitory avoidance memory: involvement of noradrenergic and cholinergic systems. The European Journal of Neuroscience, 20(10), 2804-10.
Lalumiere RT, Nguyen LT, McGaugh JL. Post-training Intrabasolateral Amygdala Infusions of Dopamine Modulate Consolidation of Inhibitory Avoidance Memory: Involvement of Noradrenergic and Cholinergic Systems. Eur J Neurosci. 2004;20(10):2804-10. PubMed PMID: 15548223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Post-training intrabasolateral amygdala infusions of dopamine modulate consolidation of inhibitory avoidance memory: involvement of noradrenergic and cholinergic systems. AU - Lalumiere,Ryan T, AU - Nguyen,Linda T, AU - McGaugh,James L, PY - 2004/11/19/pubmed PY - 2005/3/2/medline PY - 2004/11/19/entrez SP - 2804 EP - 10 JF - The European journal of neuroscience JO - Eur J Neurosci VL - 20 IS - 10 N2 - There is extensive evidence that several neurotransmitter systems within the basolateral amygdala (BLA) influence memory consolidation. The present study investigated the influence of dopamine (DA) in the BLA on the consolidation of memory for inhibitory avoidance (IA) training. Male Sprague-Dawley rats (approximately 300 g) were trained on a step-through IA task and, 48 h later, tested for retention as indexed by their latencies to enter the shock compartment on the test day. Drugs were infused into the BLA or central amygdala nucleus (CEA) immediately or 3 h after training via bilateral cannulae. DA infused into the BLA immediately after training enhanced retention, whereas DA infused into the BLA 3 h after training or into the CEA did not affect retention. Infusions of the dopaminergic antagonist cis-Flupenthixol together with DA blocked the DA-induced memory enhancement. Immediate post-training intra-BLA infusions of the D1 receptor antagonist SCH 23390 or the D2 receptor antagonist sulpiride impaired retention. beta-adrenergic or muscarinic cholinergic receptor antagonists coinfused into the BLA with DA blocked the memory enhancing effects of DA. These findings indicate that dopaminergic activation within the BLA modulates memory consolidation and that the modulation involves activation of both D1 and D2 receptors and concurrent activation of beta-adrenergic and cholinergic influences within the BLA. SN - 0953-816X UR - https://www.unboundmedicine.com/medline/citation/15548223/Post_training_intrabasolateral_amygdala_infusions_of_dopamine_modulate_consolidation_of_inhibitory_avoidance_memory:_involvement_of_noradrenergic_and_cholinergic_systems_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0953-816X&date=2004&volume=20&issue=10&spage=2804 DB - PRIME DP - Unbound Medicine ER -