Tags

Type your tag names separated by a space and hit enter

Fluconazole treatment of catheter-related right-sided endocarditis caused by Candida albicans and associated with endophthalmitis and folliculitis.
Clin Infect Dis. 1992 Feb; 14(2):422-6.CI

Abstract

An unusual case of catheter-related right-sided endocarditis, endophthalmitis, and extensive folliculitis, apparently caused by a single DNA biotype of Candida albicans, was successfully treated with a 6-month course of fluconazole plus two intravitreous doses of amphotericin B. The patient was a 21-year-old man who underwent colectomy for diffuse polyposis and developed the clinical syndrome just described following total parenteral nutrition for the treatment of purulent anal fistulas. Fluconazole was initially administered at a daily dose of 200 mg, with 600 mg daily given after 4 weeks. Clinical improvement resulted, with no relapse during 14 months of follow-up. Sequential measurements by an enzyme-linked immunosorbent inhibition assay demonstrated that levels of circulating mannoprotein antigen of C. albicans fell from 75 ng/mL to less than 1 ng/mL after the institution of fluconazole therapy. These observations seem to confirm previous reports on the efficacy of fluconazole as sole therapy for candidal endocarditis and suggest a role for serological studies in clinical monitoring of severe candidal infections.

Authors+Show Affiliations

Patologia Medica II, Università La Sapienza, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1554827

Citation

Venditti, M, et al. "Fluconazole Treatment of Catheter-related Right-sided Endocarditis Caused By Candida Albicans and Associated With Endophthalmitis and Folliculitis." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 14, no. 2, 1992, pp. 422-6.
Venditti M, De Bernardis F, Micozzi A, et al. Fluconazole treatment of catheter-related right-sided endocarditis caused by Candida albicans and associated with endophthalmitis and folliculitis. Clin Infect Dis. 1992;14(2):422-6.
Venditti, M., De Bernardis, F., Micozzi, A., Pontieri, E., Chirletti, P., Cassone, A., & Martino, P. (1992). Fluconazole treatment of catheter-related right-sided endocarditis caused by Candida albicans and associated with endophthalmitis and folliculitis. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 14(2), 422-6.
Venditti M, et al. Fluconazole Treatment of Catheter-related Right-sided Endocarditis Caused By Candida Albicans and Associated With Endophthalmitis and Folliculitis. Clin Infect Dis. 1992;14(2):422-6. PubMed PMID: 1554827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fluconazole treatment of catheter-related right-sided endocarditis caused by Candida albicans and associated with endophthalmitis and folliculitis. AU - Venditti,M, AU - De Bernardis,F, AU - Micozzi,A, AU - Pontieri,E, AU - Chirletti,P, AU - Cassone,A, AU - Martino,P, PY - 1992/2/1/pubmed PY - 1992/2/1/medline PY - 1992/2/1/entrez SP - 422 EP - 6 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 14 IS - 2 N2 - An unusual case of catheter-related right-sided endocarditis, endophthalmitis, and extensive folliculitis, apparently caused by a single DNA biotype of Candida albicans, was successfully treated with a 6-month course of fluconazole plus two intravitreous doses of amphotericin B. The patient was a 21-year-old man who underwent colectomy for diffuse polyposis and developed the clinical syndrome just described following total parenteral nutrition for the treatment of purulent anal fistulas. Fluconazole was initially administered at a daily dose of 200 mg, with 600 mg daily given after 4 weeks. Clinical improvement resulted, with no relapse during 14 months of follow-up. Sequential measurements by an enzyme-linked immunosorbent inhibition assay demonstrated that levels of circulating mannoprotein antigen of C. albicans fell from 75 ng/mL to less than 1 ng/mL after the institution of fluconazole therapy. These observations seem to confirm previous reports on the efficacy of fluconazole as sole therapy for candidal endocarditis and suggest a role for serological studies in clinical monitoring of severe candidal infections. SN - 1058-4838 UR - https://www.unboundmedicine.com/medline/citation/1554827/Fluconazole_treatment_of_catheter_related_right_sided_endocarditis_caused_by_Candida_albicans_and_associated_with_endophthalmitis_and_folliculitis_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1093/clinids/14.2.422 DB - PRIME DP - Unbound Medicine ER -