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Microalbuminuria in adults after prenatal exposure to the Dutch famine.
J Am Soc Nephrol 2005; 16(1):189-94JA

Abstract

Maternal undernutrition during gestation is associated with an increase in cardiovascular risk factors in the offspring in adult life. The effect of famine exposure during different stages of gestation on adult microalbuminuria (MA) was studied. MA was measured in 724 people, aged 48 to 53, who were born as term singletons in a university hospital in Amsterdam, the Netherlands, around the time of the Dutch famine 1944 to 1945. Twelve percent of people who were exposed to famine in mid gestation had MA (defined as albumin/creatinine ratio >/=2.5) compared with 7% of those who were not prenatally exposed to famine (odds ratio 2.1; 95% confidence interval 1.0 to 4.3). Correcting for BP, diabetes, and other influences that affect MA did not attenuate this association (adjusted odds ratio 3.2; 95% confidence interval 1.4 to 7.7). The effect of famine was independent of size at birth. Midgestation is a period of rapid increase in nephron number, which is critical in determining nephron endowment at birth. Fetal undernutrition may lead to lower nephron endowment with consequent MA in adult life.

Authors+Show Affiliations

Department of Clinical Epidemiology and Biostatistics, Academic Medical Center at the University of Amsterdam, The Netherlands. r.c.painter@amc.uva.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15548563

Citation

Painter, Rebecca C., et al. "Microalbuminuria in Adults After Prenatal Exposure to the Dutch Famine." Journal of the American Society of Nephrology : JASN, vol. 16, no. 1, 2005, pp. 189-94.
Painter RC, Roseboom TJ, van Montfrans GA, et al. Microalbuminuria in adults after prenatal exposure to the Dutch famine. J Am Soc Nephrol. 2005;16(1):189-94.
Painter, R. C., Roseboom, T. J., van Montfrans, G. A., Bossuyt, P. M., Krediet, R. T., Osmond, C., ... Bleker, O. P. (2005). Microalbuminuria in adults after prenatal exposure to the Dutch famine. Journal of the American Society of Nephrology : JASN, 16(1), pp. 189-94.
Painter RC, et al. Microalbuminuria in Adults After Prenatal Exposure to the Dutch Famine. J Am Soc Nephrol. 2005;16(1):189-94. PubMed PMID: 15548563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microalbuminuria in adults after prenatal exposure to the Dutch famine. AU - Painter,Rebecca C, AU - Roseboom,Tessa J, AU - van Montfrans,Gert A, AU - Bossuyt,Patrick M M, AU - Krediet,Raymond T, AU - Osmond,Clive, AU - Barker,David J P, AU - Bleker,Otto P, Y1 - 2004/11/17/ PY - 2004/11/19/pubmed PY - 2005/6/23/medline PY - 2004/11/19/entrez SP - 189 EP - 94 JF - Journal of the American Society of Nephrology : JASN JO - J. Am. Soc. Nephrol. VL - 16 IS - 1 N2 - Maternal undernutrition during gestation is associated with an increase in cardiovascular risk factors in the offspring in adult life. The effect of famine exposure during different stages of gestation on adult microalbuminuria (MA) was studied. MA was measured in 724 people, aged 48 to 53, who were born as term singletons in a university hospital in Amsterdam, the Netherlands, around the time of the Dutch famine 1944 to 1945. Twelve percent of people who were exposed to famine in mid gestation had MA (defined as albumin/creatinine ratio >/=2.5) compared with 7% of those who were not prenatally exposed to famine (odds ratio 2.1; 95% confidence interval 1.0 to 4.3). Correcting for BP, diabetes, and other influences that affect MA did not attenuate this association (adjusted odds ratio 3.2; 95% confidence interval 1.4 to 7.7). The effect of famine was independent of size at birth. Midgestation is a period of rapid increase in nephron number, which is critical in determining nephron endowment at birth. Fetal undernutrition may lead to lower nephron endowment with consequent MA in adult life. SN - 1046-6673 UR - https://www.unboundmedicine.com/medline/citation/15548563/Microalbuminuria_in_adults_after_prenatal_exposure_to_the_Dutch_famine_ L2 - http://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=15548563 DB - PRIME DP - Unbound Medicine ER -