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Memory consolidation and reconsolidation in the rat pup require protein synthesis.
J Neurosci. 2004 Nov 17; 24(46):10488-92.JN

Abstract

Little is known about the ontogenesis of memory, whether it appears with its full characteristics or whether they emerge progressively with development. In the adult, basic characteristics of memory processing are consolidation of memory after acquisition and reconsolidation after retrieval. Here, using a conditioned aversion paradigm and postlearning or postreactivation injection of a protein synthesis inhibitor, we show that memory acquired by rat pups as early as postnatal day 3 requires time-dependent protein synthesis after both learning and reactivation. These results present the first evidence suggesting that consolidation and reconsolidation are original properties of memory function.

Authors+Show Affiliations

Laboratoire de Neurobiologie de l'Apprentissage, de la Mémoire, et de la Communication, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8620, Université Paris-sud, 91405 Orsay Cedex, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15548663

Citation

Gruest, Nadège, et al. "Memory Consolidation and Reconsolidation in the Rat Pup Require Protein Synthesis." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, vol. 24, no. 46, 2004, pp. 10488-92.
Gruest N, Richer P, Hars B. Memory consolidation and reconsolidation in the rat pup require protein synthesis. J Neurosci. 2004;24(46):10488-92.
Gruest, N., Richer, P., & Hars, B. (2004). Memory consolidation and reconsolidation in the rat pup require protein synthesis. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 24(46), 10488-92.
Gruest N, Richer P, Hars B. Memory Consolidation and Reconsolidation in the Rat Pup Require Protein Synthesis. J Neurosci. 2004 Nov 17;24(46):10488-92. PubMed PMID: 15548663.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Memory consolidation and reconsolidation in the rat pup require protein synthesis. AU - Gruest,Nadège, AU - Richer,Paulette, AU - Hars,Bernard, PY - 2004/11/19/pubmed PY - 2005/6/23/medline PY - 2004/11/19/entrez SP - 10488 EP - 92 JF - The Journal of neuroscience : the official journal of the Society for Neuroscience JO - J Neurosci VL - 24 IS - 46 N2 - Little is known about the ontogenesis of memory, whether it appears with its full characteristics or whether they emerge progressively with development. In the adult, basic characteristics of memory processing are consolidation of memory after acquisition and reconsolidation after retrieval. Here, using a conditioned aversion paradigm and postlearning or postreactivation injection of a protein synthesis inhibitor, we show that memory acquired by rat pups as early as postnatal day 3 requires time-dependent protein synthesis after both learning and reactivation. These results present the first evidence suggesting that consolidation and reconsolidation are original properties of memory function. SN - 1529-2401 UR - https://www.unboundmedicine.com/medline/citation/15548663/Memory_consolidation_and_reconsolidation_in_the_rat_pup_require_protein_synthesis_ L2 - http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=15548663 DB - PRIME DP - Unbound Medicine ER -