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Soy isoflavones may protect against orchidectomy-induced bone loss in aged male rats.
Calcif Tissue Int 2005; 76(1):56-62CT

Abstract

Evidence from several studies suggests that soy protein and/or its isoflavones may have beneficial effects on bone in postmenopausal women and animal models who have osteoporosis. The present study examined the dose-dependent effects of soy isoflavones in the context of soy protein or casein on the male skeleton. Thirteen-month-old male Fisher 344 rats were orchidectomized (ORX; 5 groups) or sham-operated (Sham; 1 group) and immediately placed on dietary treatments for 180 days. Diets were semi-purified and the protein source was either casein (Sham and ORX; controls), casein with two added doses of isoflavones (Iso1; 600 mg/kg diet and Iso2; 1200 mg/kg diet), soy protein with normal isoflavones content (Soy; 600 mg/kg diet), or soy protein with added isoflavones (Soy+; 1200 mg/kg diet). A 7% loss of whole body bone mineral density (BMD) was observed due to orchidectomy; however, the ORX induced BMD loss was significantly reduced to 4.3 and 4.7 % with the Soy and Soy+, respectively. Both doses of isoflavones in conjunction with casein also reduced the loss of whole body BMD, albeit not significantly different from ORX control animals. Trabecular bone histomorphometric analysis of the proximal tibia further supported the bone-sparing role of soy isoflavones as indicated by higher percent bone volume and trabecular number, and lower trabecular separation. We conclude that isoflavones exert modest beneficial effects on the male skeleton whether provided with casein or a soy protein.

Authors+Show Affiliations

Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, USA, arjmand@okstate.edu.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

15549639

Citation

Khalil, D A., et al. "Soy Isoflavones May Protect Against Orchidectomy-induced Bone Loss in Aged Male Rats." Calcified Tissue International, vol. 76, no. 1, 2005, pp. 56-62.
Khalil DA, Lucas EA, Smith BJ, et al. Soy isoflavones may protect against orchidectomy-induced bone loss in aged male rats. Calcif Tissue Int. 2005;76(1):56-62.
Khalil, D. A., Lucas, E. A., Smith, B. J., Soung, D. Y., Devareddy, L., Juma, S., ... Arjmandi, B. H. (2005). Soy isoflavones may protect against orchidectomy-induced bone loss in aged male rats. Calcified Tissue International, 76(1), pp. 56-62.
Khalil DA, et al. Soy Isoflavones May Protect Against Orchidectomy-induced Bone Loss in Aged Male Rats. Calcif Tissue Int. 2005;76(1):56-62. PubMed PMID: 15549639.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy isoflavones may protect against orchidectomy-induced bone loss in aged male rats. AU - Khalil,D A, AU - Lucas,E A, AU - Smith,B J, AU - Soung,D Y, AU - Devareddy,L, AU - Juma,S, AU - Akhter,M P, AU - Recker,R, AU - Arjmandi,B H, Y1 - 2004/11/04/ PY - 2004/01/29/received PY - 2004/07/30/accepted PY - 2004/11/19/pubmed PY - 2005/5/13/medline PY - 2004/11/19/entrez SP - 56 EP - 62 JF - Calcified tissue international JO - Calcif. Tissue Int. VL - 76 IS - 1 N2 - Evidence from several studies suggests that soy protein and/or its isoflavones may have beneficial effects on bone in postmenopausal women and animal models who have osteoporosis. The present study examined the dose-dependent effects of soy isoflavones in the context of soy protein or casein on the male skeleton. Thirteen-month-old male Fisher 344 rats were orchidectomized (ORX; 5 groups) or sham-operated (Sham; 1 group) and immediately placed on dietary treatments for 180 days. Diets were semi-purified and the protein source was either casein (Sham and ORX; controls), casein with two added doses of isoflavones (Iso1; 600 mg/kg diet and Iso2; 1200 mg/kg diet), soy protein with normal isoflavones content (Soy; 600 mg/kg diet), or soy protein with added isoflavones (Soy+; 1200 mg/kg diet). A 7% loss of whole body bone mineral density (BMD) was observed due to orchidectomy; however, the ORX induced BMD loss was significantly reduced to 4.3 and 4.7 % with the Soy and Soy+, respectively. Both doses of isoflavones in conjunction with casein also reduced the loss of whole body BMD, albeit not significantly different from ORX control animals. Trabecular bone histomorphometric analysis of the proximal tibia further supported the bone-sparing role of soy isoflavones as indicated by higher percent bone volume and trabecular number, and lower trabecular separation. We conclude that isoflavones exert modest beneficial effects on the male skeleton whether provided with casein or a soy protein. SN - 0171-967X UR - https://www.unboundmedicine.com/medline/citation/15549639/Soy_isoflavones_may_protect_against_orchidectomy_induced_bone_loss_in_aged_male_rats_ L2 - https://dx.doi.org/10.1007/s00223-004-0018-z DB - PRIME DP - Unbound Medicine ER -