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Children's acceptance and tolerance of chlorhexidine and benzydamine oral rinses in the treatment of chemotherapy-induced oropharyngeal mucositis.
Eur J Oncol Nurs 2004; 8(4):341-9EJ

Abstract

Oral care is of great importance in the prevention of chemotherapy-induced oropharyngeal mucositis. Although considerable attention has been given in improving oral care practices, patients' acceptance and tolerance of oral rinses is a continuing problem in oral care. A randomized crossover design was used to determine the relative acceptability and tolerability of chlorhexidine and benzydamine oral rinse agents in children receiving chemotherapy. At the end of the study, each subject was asked to compare these two agents in relation to stinging and taste, as well as his/her perception in reducing mucositis. Thirty-four children aged 6-17 years completed two courses of chemotherapy during which they alternately practiced oral care using chlorhexidine then benzydamine or benzydamine then chlorhexidine. All of the children tolerated the agents well and continued with rinsing throughout the study. Only a few children had to resort to diluting the agents with normal saline or water. Fifty-nine percent of children reported that the stinging associated with benzydamine was more accepted than chlorhexidine. The taste of both these agents was accepted by 50% of children. Approximately 60% of children reported that chlorhexidine was more helpful than benzydamine in reducing mucositis. About 47% and 50% of them preferred chlorhexidine and benzydamine in their subsequent chemotherapy, respectively. In conclusion, chlorhexidine and benzydamine are acceptable and well-tolerated by children over the age 6 years old.

Authors+Show Affiliations

Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, 804A, Esther Lee Building, Shatin, New Territories, Hong Kong. kariskwong@cuhk.edu.hk

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15550364

Citation

Cheng, K K F.. "Children's Acceptance and Tolerance of Chlorhexidine and Benzydamine Oral Rinses in the Treatment of Chemotherapy-induced Oropharyngeal Mucositis." European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society, vol. 8, no. 4, 2004, pp. 341-9.
Cheng KK. Children's acceptance and tolerance of chlorhexidine and benzydamine oral rinses in the treatment of chemotherapy-induced oropharyngeal mucositis. Eur J Oncol Nurs. 2004;8(4):341-9.
Cheng, K. K. (2004). Children's acceptance and tolerance of chlorhexidine and benzydamine oral rinses in the treatment of chemotherapy-induced oropharyngeal mucositis. European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society, 8(4), pp. 341-9.
Cheng KK. Children's Acceptance and Tolerance of Chlorhexidine and Benzydamine Oral Rinses in the Treatment of Chemotherapy-induced Oropharyngeal Mucositis. Eur J Oncol Nurs. 2004;8(4):341-9. PubMed PMID: 15550364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Children's acceptance and tolerance of chlorhexidine and benzydamine oral rinses in the treatment of chemotherapy-induced oropharyngeal mucositis. A1 - Cheng,K K F, PY - 2004/11/20/pubmed PY - 2005/2/3/medline PY - 2004/11/20/entrez SP - 341 EP - 9 JF - European journal of oncology nursing : the official journal of European Oncology Nursing Society JO - Eur J Oncol Nurs VL - 8 IS - 4 N2 - Oral care is of great importance in the prevention of chemotherapy-induced oropharyngeal mucositis. Although considerable attention has been given in improving oral care practices, patients' acceptance and tolerance of oral rinses is a continuing problem in oral care. A randomized crossover design was used to determine the relative acceptability and tolerability of chlorhexidine and benzydamine oral rinse agents in children receiving chemotherapy. At the end of the study, each subject was asked to compare these two agents in relation to stinging and taste, as well as his/her perception in reducing mucositis. Thirty-four children aged 6-17 years completed two courses of chemotherapy during which they alternately practiced oral care using chlorhexidine then benzydamine or benzydamine then chlorhexidine. All of the children tolerated the agents well and continued with rinsing throughout the study. Only a few children had to resort to diluting the agents with normal saline or water. Fifty-nine percent of children reported that the stinging associated with benzydamine was more accepted than chlorhexidine. The taste of both these agents was accepted by 50% of children. Approximately 60% of children reported that chlorhexidine was more helpful than benzydamine in reducing mucositis. About 47% and 50% of them preferred chlorhexidine and benzydamine in their subsequent chemotherapy, respectively. In conclusion, chlorhexidine and benzydamine are acceptable and well-tolerated by children over the age 6 years old. SN - 1462-3889 UR - https://www.unboundmedicine.com/medline/citation/15550364/Children's_acceptance_and_tolerance_of_chlorhexidine_and_benzydamine_oral_rinses_in_the_treatment_of_chemotherapy_induced_oropharyngeal_mucositis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1462388904000328 DB - PRIME DP - Unbound Medicine ER -