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Insulin resistance, body mass index, waist circumference are independent risk factor for high blood pressure.

Abstract

OBJECTIVES

The purpose of the present study was to investigate the relationships between blood pressure (BP), insulin resistance as determined by a homeostasis model (HOMA-IR), and body fat distribution.

METHODS

Anthropometric indices of adiposity, metabolic variables (fasting serum insulin and a homeostasis model assessment [HOMA] index of insulin sensitivity), BP and several cardiovascular risk factors were measured during a cross sectional survey of 53477 apparently healthy Korean subjects who requested a health status check. Hypertension was defined as a systolic BP > or = 140 mmHg or a diastolic BP > or = 90 mmHg and we excluded the subjects taking BP-lowering medication.

RESULTS

Systolic and diastolic blood pressure (SBP, DBP) were positively and significantly associated with age, body mass index, waist circumference, and waist/hip ratio. In addition, SBP and DBP were positively associated with fasting serum insulin levels and the HOMA index. By multiple regression analysis age, waist circumference, body mass index, HOMA index and female sex were independently associated with either increased SBP or DBP. When the population is divided into quintiles according to insulin resistance (measured by HOMA analysis) prevalence of hypertension in the second, third, fourth and fifth quintiles compared to subjects in the first quintile are 1.004(95% CI 0.875-1.152, p = 0.957), 1.200(95% CI 1.052-1.369, p = 0.007), 1.312(95% CI 1.151-1.494 p < 0.001 ), and 1.603(95% CI 1.408-1.825 p < 0.001). In addition age, sex, body mass index and waist circumference were found to be significantly associated with hypertension.

CONCLUSION

Our results showed that insulin resistance, body mass index and waist circumference are independent risk factors of a high BP in Koreans.

Authors+Show Affiliations

,

Division of Cardiology, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, South Korea. mdkcsung@samsung.co.kr

Source

MeSH

Adult
Blood Pressure
Body Mass Index
Female
Humans
Hypertension
Insulin Resistance
Logistic Models
Male
Middle Aged
Multivariate Analysis
Prevalence
Risk Factors
Waist-Hip Ratio

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15554457

Citation

Sung, Ki Chul, and Seung Ho Ryu. "Insulin Resistance, Body Mass Index, Waist Circumference Are Independent Risk Factor for High Blood Pressure." Clinical and Experimental Hypertension (New York, N.Y. : 1993), vol. 26, no. 6, 2004, pp. 547-56.
Sung KC, Ryu SH. Insulin resistance, body mass index, waist circumference are independent risk factor for high blood pressure. Clin Exp Hypertens. 2004;26(6):547-56.
Sung, K. C., & Ryu, S. H. (2004). Insulin resistance, body mass index, waist circumference are independent risk factor for high blood pressure. Clinical and Experimental Hypertension (New York, N.Y. : 1993), 26(6), pp. 547-56.
Sung KC, Ryu SH. Insulin Resistance, Body Mass Index, Waist Circumference Are Independent Risk Factor for High Blood Pressure. Clin Exp Hypertens. 2004;26(6):547-56. PubMed PMID: 15554457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin resistance, body mass index, waist circumference are independent risk factor for high blood pressure. AU - Sung,Ki Chul, AU - Ryu,Seung Ho, PY - 2004/11/24/pubmed PY - 2005/2/11/medline PY - 2004/11/24/entrez SP - 547 EP - 56 JF - Clinical and experimental hypertension (New York, N.Y. : 1993) JO - Clin. Exp. Hypertens. VL - 26 IS - 6 N2 - OBJECTIVES: The purpose of the present study was to investigate the relationships between blood pressure (BP), insulin resistance as determined by a homeostasis model (HOMA-IR), and body fat distribution. METHODS: Anthropometric indices of adiposity, metabolic variables (fasting serum insulin and a homeostasis model assessment [HOMA] index of insulin sensitivity), BP and several cardiovascular risk factors were measured during a cross sectional survey of 53477 apparently healthy Korean subjects who requested a health status check. Hypertension was defined as a systolic BP > or = 140 mmHg or a diastolic BP > or = 90 mmHg and we excluded the subjects taking BP-lowering medication. RESULTS: Systolic and diastolic blood pressure (SBP, DBP) were positively and significantly associated with age, body mass index, waist circumference, and waist/hip ratio. In addition, SBP and DBP were positively associated with fasting serum insulin levels and the HOMA index. By multiple regression analysis age, waist circumference, body mass index, HOMA index and female sex were independently associated with either increased SBP or DBP. When the population is divided into quintiles according to insulin resistance (measured by HOMA analysis) prevalence of hypertension in the second, third, fourth and fifth quintiles compared to subjects in the first quintile are 1.004(95% CI 0.875-1.152, p = 0.957), 1.200(95% CI 1.052-1.369, p = 0.007), 1.312(95% CI 1.151-1.494 p < 0.001 ), and 1.603(95% CI 1.408-1.825 p < 0.001). In addition age, sex, body mass index and waist circumference were found to be significantly associated with hypertension. CONCLUSION: Our results showed that insulin resistance, body mass index and waist circumference are independent risk factors of a high BP in Koreans. SN - 1064-1963 UR - https://www.unboundmedicine.com/medline/citation/15554457/Insulin_resistance_body_mass_index_waist_circumference_are_independent_risk_factor_for_high_blood_pressure_ L2 - https://medlineplus.gov/highbloodpressure.html DB - PRIME DP - Unbound Medicine ER -