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Nonalcoholic steatohepatitis.
Neth J Med. 2004 Jul-Aug; 62(7):217-24.NJ

Abstract

Nonalcoholic steatohepatitis (NASH) is an underdiagnosed liver disease characterised by steatosis, necroinflammation and fibrosis. This disease may eventually develop into cirrhosis and hepatocellular carcinoma. NASH is highly prevalent among obese individuals and among patients with diabetes mellitus type 2. Nonalcoholic fatty liver (NAFL), a precursor of NASH, is the main cause of elevated serum liver enzymes among the general population. Insulin resistance is a major aetiological factor in NASH. Gradual weight loss, physical exercise and drugs that improve insulin sensitivity are potential therapies.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, Academic Medical Centre, PO Box 22660, 1100 DD Amsterdam, the Netherlands. pljansen@amc.uva.nl

Pub Type(s)

Duplicate Publication
Journal Article
Review

Language

eng

PubMed ID

15554595

Citation

Jansen, P L M.. "Nonalcoholic Steatohepatitis." The Netherlands Journal of Medicine, vol. 62, no. 7, 2004, pp. 217-24.
Jansen PL. Nonalcoholic steatohepatitis. Neth J Med. 2004;62(7):217-24.
Jansen, P. L. (2004). Nonalcoholic steatohepatitis. The Netherlands Journal of Medicine, 62(7), 217-24.
Jansen PL. Nonalcoholic Steatohepatitis. Neth J Med. 2004 Jul-Aug;62(7):217-24. PubMed PMID: 15554595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonalcoholic steatohepatitis. A1 - Jansen,P L M, PY - 2004/11/24/pubmed PY - 2004/12/31/medline PY - 2004/11/24/entrez SP - 217 EP - 24 JF - The Netherlands journal of medicine JO - Neth J Med VL - 62 IS - 7 N2 - Nonalcoholic steatohepatitis (NASH) is an underdiagnosed liver disease characterised by steatosis, necroinflammation and fibrosis. This disease may eventually develop into cirrhosis and hepatocellular carcinoma. NASH is highly prevalent among obese individuals and among patients with diabetes mellitus type 2. Nonalcoholic fatty liver (NAFL), a precursor of NASH, is the main cause of elevated serum liver enzymes among the general population. Insulin resistance is a major aetiological factor in NASH. Gradual weight loss, physical exercise and drugs that improve insulin sensitivity are potential therapies. SN - 0300-2977 UR - https://www.unboundmedicine.com/medline/citation/15554595/Nonalcoholic_steatohepatitis_ L2 - http://www.njmonline.nl/njm/getarticle.php?v=62&i=7&p=217 DB - PRIME DP - Unbound Medicine ER -