Tags

Type your tag names separated by a space and hit enter

Paternal alcohol dependence and offspring suicidal behaviors in a children-of-twins study.
Drug Alcohol Depend. 2004 Dec 07; 76 Suppl:S69-77.DA

Abstract

INTRODUCTION

In substance abusing families, sources of familial comorbidity are potentially confounded by genetic-environmental (GE) interplays. The children-of-twins (COT) design can be used to elucidate the association of a parental trait and an offspring outcome such as the association of parental alcoholism and offspring suicidality.

METHODS

We examined the association of paternal alcoholism and offspring suicidal behaviors in an adolescent and young adult COT sample of 'Vietnam Era Twins' offspring who had completed an interview including a comprehensive assessment of lifetime suicidal behaviors. We stratified the COT sample into four groups contingent upon paternal zygosity, MZ versus DZ, and lifetime paternal alcohol dependence history (AD), positive versus negative. We examined whether the relationship of paternal alcoholism and offspring suicidality was best explained by genetic predispositions common to alcoholism and suicidality or by GE interplay--environmental influences correlated with parental alcoholism or the interaction of genetic and environmental factors.

RESULTS

Our results suggest a main effect of paternal alcoholism on offspring suicide attempt; COT analyses do not support a purely genetic explanation for this association.

DISCUSSION

Suicide attempts probably result from GE interplays and must be studied in genetically informative samples of offspring of substance abusing parents.

Authors+Show Affiliations

Department of Psychiatry, Box 8134, Washington University School of Medicine, 40 North Kingshighway, Suite One, St. Louis, MO 63108, USA. glowinsa@matlock.wustl.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Twin Study

Language

eng

PubMed ID

15555818

Citation

Glowinski, Anne L., et al. "Paternal Alcohol Dependence and Offspring Suicidal Behaviors in a Children-of-twins Study." Drug and Alcohol Dependence, vol. 76 Suppl, 2004, pp. S69-77.
Glowinski AL, Jacob T, Bucholz KK, et al. Paternal alcohol dependence and offspring suicidal behaviors in a children-of-twins study. Drug Alcohol Depend. 2004;76 Suppl:S69-77.
Glowinski, A. L., Jacob, T., Bucholz, K. K., Scherrer, J. F., True, W., & Heath, A. C. (2004). Paternal alcohol dependence and offspring suicidal behaviors in a children-of-twins study. Drug and Alcohol Dependence, 76 Suppl, S69-77.
Glowinski AL, et al. Paternal Alcohol Dependence and Offspring Suicidal Behaviors in a Children-of-twins Study. Drug Alcohol Depend. 2004 Dec 7;76 Suppl:S69-77. PubMed PMID: 15555818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paternal alcohol dependence and offspring suicidal behaviors in a children-of-twins study. AU - Glowinski,Anne L, AU - Jacob,Theodore, AU - Bucholz,Kathleen K, AU - Scherrer,Jeffrey F, AU - True,William, AU - Heath,Andrew C, PY - 2004/07/08/received PY - 2004/08/04/accepted PY - 2004/11/24/pubmed PY - 2005/5/4/medline PY - 2004/11/24/entrez SP - S69 EP - 77 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 76 Suppl N2 - INTRODUCTION: In substance abusing families, sources of familial comorbidity are potentially confounded by genetic-environmental (GE) interplays. The children-of-twins (COT) design can be used to elucidate the association of a parental trait and an offspring outcome such as the association of parental alcoholism and offspring suicidality. METHODS: We examined the association of paternal alcoholism and offspring suicidal behaviors in an adolescent and young adult COT sample of 'Vietnam Era Twins' offspring who had completed an interview including a comprehensive assessment of lifetime suicidal behaviors. We stratified the COT sample into four groups contingent upon paternal zygosity, MZ versus DZ, and lifetime paternal alcohol dependence history (AD), positive versus negative. We examined whether the relationship of paternal alcoholism and offspring suicidality was best explained by genetic predispositions common to alcoholism and suicidality or by GE interplay--environmental influences correlated with parental alcoholism or the interaction of genetic and environmental factors. RESULTS: Our results suggest a main effect of paternal alcoholism on offspring suicide attempt; COT analyses do not support a purely genetic explanation for this association. DISCUSSION: Suicide attempts probably result from GE interplays and must be studied in genetically informative samples of offspring of substance abusing parents. SN - 0376-8716 UR - https://www.unboundmedicine.com/medline/citation/15555818/Paternal_alcohol_dependence_and_offspring_suicidal_behaviors_in_a_children_of_twins_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(04)00217-0 DB - PRIME DP - Unbound Medicine ER -